2B71


Conserved Protein Domain Family
Pro_isomerase

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pfam00160: Pro_isomerase 
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Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.
Statistics
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PSSM-Id: 333887
View PSSM: pfam00160
Aligned: 74 rows
Threshold Bit Score: 88.4544
Threshold Setting Gi: 122097891
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B71_A        40 YITIYT-N---L-GDFEVELYWYHSPKTCLNFYTLCeMG--------------------------FYD--NTIFHR-VIp 85
gi 124472291  13 FMTMQVgKr-qP-VQVIIRLFDQQCPKTCENFRKLC-Qt--------------------------KYG--GTNFHR-CSe 60
gi 122097891 246 YFDVEVrDtriQ-GRLIIQLFTEACPQVVLEFMRACtQG--------------------------NSA--AITFSRtLTp 296
gi 122102527  34 HLEVQTdEk-aP-ETLIVGLYGNLVPKTVNNFIALC-EGtki--------------------edkHYSyvDSAFHR-VIp 89
gi 122121563  22 FMDVKHnKq--PiGRITFGLFGKLAPKTVANFRHIClRGin----------------------gtSYV--GARFHR-VVd 74
gi 122097325   2 sliIETs----L-GDLEVDLFVQKAPEISKNFLKLCkLK--------------------------HYN--NALFYE-VQk 47
gi 74602009    4 LLETTE-------GNIVIDLFIDQQPLACYNFLKLCkLN--------------------------YYF--FTPFYN-LHk 47
gi 122081186  82 FMDVAIgSc-sP-KRIEYELFTRKCPVAVENFVKLC-TGenvlprvpstagmgdpsfgdqflpqvTYK--NSTFHR-VHr 155
gi 927372977   2 svllETn----A-GNLVIDLFVDSAPNESRTFIALClSK--------------------------FYH--YSPFVN-VRk 47
gi 83284719   22 afsIQQsSk-lL-GTVVLELFTDIAPATCANFIKYIkD---------------------------GYQ--GTPLHR-IVp 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B71_A        86 nFVIQGGDPTGTg--------------KGgk-siYGE-------YfeDEIn-KELKH-TgA--GILSMS-NNGp----NT 134
gi 124472291  61 nFIAQGGDYERGd--------------GT-----GGTsiwgnyfK--DEN--FNIRHdK-R--GIVSMA-NRGa----NT 109
gi 122097891 297 -mWLEGRLDMGPstvlk------qdlrNI-------------------EHdfDVLNH-G-VdaGILSFPsRYVrs--hLC 346
gi 122102527  90 nFMVQGGDIVNr--------------nGT-----GSIsiyggtfE--DEN--FKAKH-K-K--GVIAMA-NRGp----NT 137
gi 122121563  75 rFLVQGGDILHGd--------------GTgsisiYGd-------YfeDEDkaLAVEHnR-P--GYLGMA-NRGp----DT 125
gi 122097325  48 nYLTSIKSKKATtv------------fVEtg--gDQQ-------YihDEIdpTNKHN-K-I--GLLSTS-NIGq----DR 97
gi 74602009   48 dLIVSSGDPDYPentdgdainsfgdvnVNnttvkQNky-----lPvpNSQh-EYVDN-S-I--GLVSFV-TKKdtngkDL 116
gi 122081186 156 gYLIQGGDVVSGq--------------GT-----EQLsiygetfDapDEV--SSSVFdQ-R--GLVGTA-VSAp----HL 206
gi 927372977  48 nVAVDSGNPCYPdp-----------laAPqp-dkNIN-------YtpSSH---LSPE-K-L--GQVLFT-SKg-----DE 95
gi 83284719   70 nGWVQGGDIVDGsgkg------------------------dpgfVlpDETy--SVKHdA-P--GVLGMA--TGgq--pHT 116
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2B71_A       135 N-SSQFFI-TLAPLP--HLDG-KH-TIFARVS--KNMTCIENIAS---Vqttatn--kpifdLKILRT 189
gi 124472291 110 N-GSQFFF-TLTACP--QLDG-KH-VAFGEII--SGFEILDQISEi--Styggd----pkelVQILTA 163
gi 122097891 347 S-AINFTI-SFQPLS--ILNG--KrIAFGKVR--KGLHLLERIQD---Atghla---tsqgvVLITGC 400
gi 122102527 138 N-GSQFYI-TTVATS--WLDG-RH-VVFGELL--EGEYTLQAIEAt--Gtdsgk----psaqTIIKSC 191
gi 122121563 126 N-GCQFYV-TTVGAK--WLDG-KH-TVFGKVL--EGMDTIYAIED---Vktdtdd--fpvqpVVISNC 180
gi 122097325  98 N-TSEFFI-TLTSSHlqHFDE-KH-TIFGQVQ--VGIDILEKFNTdviVdndnk----pyinHRILht 155
gi 74602009  117 ViGSQFTI-SLTENTe-NLKSfSQ-VYFGKVV--EGFQVLEKINL---SvvenletrrllkdIRITHT 176
gi 122081186 207 N-GSQFFIlTAKEAP--HLNG-TC-ICFGRVV--KGFDAVEEIERv-pLtpsgf----psrrVTIVDC 262
gi 927372977  96 F-SPEFSI-CLGPVT--DISG----HVFGTIG--EGFTTLEYIND---Cvldeag--rplkdIRILHT 148
gi 83284719  117 A-NTQFYI-SLSPLP--FLDG-KR-VAFGRVLnkQSLENLLALQT---Lptfqne--rpvpdVVIASC 173
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