2B71


Conserved Protein Domain Family
Pro_isomerase

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pfam00160: Pro_isomerase 
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Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.
Statistics
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PSSM-Id: 333887
View PSSM: pfam00160
Aligned: 74 rows
Threshold Bit Score: 88.4544
Threshold Setting Gi: 122097891
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2B71_A        40 YITIYT-N---L-GDFEVELYWYHSPKTCLNFYTLCeMG--------------------------FYD--NTIFHR-VIp 85  Plasmodium yoelii
A0BG75        13 FMTMQVgKr-qP-VQVIIRLFDQQCPKTCENFRKLC-Qt--------------------------KYG--GTNFHR-CSe 60  Paramecium tetr...
Q28WV8       246 YFDVEVrDtriQ-GRLIIQLFTEACPQVVLEFMRACtQG--------------------------NSA--AITFSRtLTp 296 Drosophila pseu...
Q4N689        34 HLEVQTdEk-aP-ETLIVGLYGNLVPKTVNNFIALC-EGtki--------------------edkHYSyvDSAFHR-VIp 89  Theileria parva
Q29NN3        22 FMDVKHnKq--PiGRITFGLFGKLAPKTVANFRHIClRGin----------------------gtSYV--GARFHR-VVd 74  Drosophila pseu...
Q23JQ1         2 sliIETs----L-GDLEVDLFVQKAPEISKNFLKLCkLK--------------------------HYN--NALFYE-VQk 47  Tetrahymena the...
Q6BPQ5         4 LLETTE-------GNIVIDLFIDQQPLACYNFLKLCkLN--------------------------YYF--FTPFYN-LHk 47  Debaryomyces ha...
Q4DNS3        82 FMDVAIgSc-sP-KRIEYELFTRKCPVAVENFVKLC-TGenvlprvpstagmgdpsfgdqflpqvTYK--NSTFHR-VHr 155 Trypanosoma cruzi
XP_013932339   2 svllETn----A-GNLVIDLFVDSAPNESRTFIALClSK--------------------------FYH--YSPFVN-VRk 47  Ogataea parapol...
ABC02023      22 afsIQQsSk-lL-GTVVLELFTDIAPATCANFIKYIkD---------------------------GYQ--GTPLHR-IVp 69  Chlamydomonas r...
2B71_A        86 nFVIQGGDPTGTg--------------KGgk-siYGE-------YfeDEIn-KELKH-TgA--GILSMS-NNGp----NT 134 Plasmodium yoelii
A0BG75        61 nFIAQGGDYERGd--------------GT-----GGTsiwgnyfK--DEN--FNIRHdK-R--GIVSMA-NRGa----NT 109 Paramecium tetr...
Q28WV8       297 -mWLEGRLDMGPstvlk------qdlrNI-------------------EHdfDVLNH-G-VdaGILSFPsRYVrs--hLC 346 Drosophila pseu...
Q4N689        90 nFMVQGGDIVNr--------------nGT-----GSIsiyggtfE--DEN--FKAKH-K-K--GVIAMA-NRGp----NT 137 Theileria parva
Q29NN3        75 rFLVQGGDILHGd--------------GTgsisiYGd-------YfeDEDkaLAVEHnR-P--GYLGMA-NRGp----DT 125 Drosophila pseu...
Q23JQ1        48 nYLTSIKSKKATtv------------fVEtg--gDQQ-------YihDEIdpTNKHN-K-I--GLLSTS-NIGq----DR 97  Tetrahymena the...
Q6BPQ5        48 dLIVSSGDPDYPentdgdainsfgdvnVNnttvkQNky-----lPvpNSQh-EYVDN-S-I--GLVSFV-TKKdtngkDL 116 Debaryomyces ha...
Q4DNS3       156 gYLIQGGDVVSGq--------------GT-----EQLsiygetfDapDEV--SSSVFdQ-R--GLVGTA-VSAp----HL 206 Trypanosoma cruzi
XP_013932339  48 nVAVDSGNPCYPdp-----------laAPqp-dkNIN-------YtpSSH---LSPE-K-L--GQVLFT-SKg-----DE 95  Ogataea parapol...
ABC02023      70 nGWVQGGDIVDGsgkg------------------------dpgfVlpDETy--SVKHdA-P--GVLGMA--TGgq--pHT 116 Chlamydomonas r...
2B71_A       135 N-SSQFFI-TLAPLP--HLDG-KH-TIFARVS--KNMTCIENIAS---Vqttatn--kpifdLKILRT 189 Plasmodium yoelii
A0BG75       110 N-GSQFFF-TLTACP--QLDG-KH-VAFGEII--SGFEILDQISEi--Styggd----pkelVQILTA 163 Paramecium tetraurelia
Q28WV8       347 S-AINFTI-SFQPLS--ILNG--KrIAFGKVR--KGLHLLERIQD---Atghla---tsqgvVLITGC 400 Drosophila pseudoobscura
Q4N689       138 N-GSQFYI-TTVATS--WLDG-RH-VVFGELL--EGEYTLQAIEAt--Gtdsgk----psaqTIIKSC 191 Theileria parva
Q29NN3       126 N-GCQFYV-TTVGAK--WLDG-KH-TVFGKVL--EGMDTIYAIED---Vktdtdd--fpvqpVVISNC 180 Drosophila pseudoobscura
Q23JQ1        98 N-TSEFFI-TLTSSHlqHFDE-KH-TIFGQVQ--VGIDILEKFNTdviVdndnk----pyinHRILht 155 Tetrahymena thermophila SB210
Q6BPQ5       117 ViGSQFTI-SLTENTe-NLKSfSQ-VYFGKVV--EGFQVLEKINL---SvvenletrrllkdIRITHT 176 Debaryomyces hansenii
Q4DNS3       207 N-GSQFFIlTAKEAP--HLNG-TC-ICFGRVV--KGFDAVEEIERv-pLtpsgf----psrrVTIVDC 262 Trypanosoma cruzi
XP_013932339  96 F-SPEFSI-CLGPVT--DISG----HVFGTIG--EGFTTLEYIND---Cvldeag--rplkdIRILHT 148 Ogataea parapolymorpha DL-1
ABC02023     117 A-NTQFYI-SLSPLP--FLDG-KR-VAFGRVLnkQSLENLLALQT---Lptfqne--rpvpdVVIASC 173 Chlamydomonas reinhardtii
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