1WAO,2NYL,1AUI,5OBL,3ICF,1KBP,1XZW,4NZV,4B2O,1T71


Conserved Protein Domain Family
Metallophos

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pfam00149: Metallophos 
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Calcineurin-like phosphoesterase
This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.
Statistics
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Aligned: 334 rows
Threshold Bit Score: 29.6389
Threshold Setting Gi: 6136236
Created: 19-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WAO_1 214 KITVCGDTH----------------GQFYDLLNIFElnGL-PSEt---NP-----YIFn---GDf------VDRG----- 254 human
O13781  39 NILHTTDIHgwlaghardkrysgdlGDFASFVQHMK--HL-AKQk---DV-----DLLlvdtGDl------HDGTgls-- 99  Schizosaccharomyces p...
P38887  45 NFIHTTDTHgwlgshlsqndydadwGDFVAFVDILR--EK-ILRq---SR-----DVIvidtGDkrdgnglSDATw---- 109 Saccharomyces cerevis...
Q9US39  49 NFIHTTDTHgwlgghlrdarykadfGEFKSFALRMK--ELaDFK----GV-----DLLmvdtGDlhdgnglSDASd---- 113 Schizosaccharomyces p...
Q9RBM2 104 KIAFIGDTGcrinmlf---qqecnsVDSWPLKKNLD--SI-ALH----KP-----DLIih-vGDy------HYRQtkcrn 161 Wolbachia sp. wRi
O13765  17 RVGVQGCCH----------------GILDNLYILAE--KR--------KV-----DLLii-gGDfq---alRNVS----- 56  Schizosaccharomyces p...
Q9UK59   2 RVAVAGCCH----------------GELDKIYETLA--LAe-------RRgpgpvDLLlc-cGDfq---avRNEA----- 47  human
Q966M6  42 RIAVVGCSH----------------GEMDAIYETMT--LI-EQKng-yKF-----DLLic-cGDyq---avRNYG----- 87  Caenorhabditis elegans
P24309   5 RIAVQGCCH----------------GQLNQIYKEVS--RI-HAKt---PI-----DLLii-lGDfq---siRDGQ----- 48  Saccharomyces cerevis...
Q9X1X0   8 KILHTSDWHlgvtsw----tssrpvDRREELKKALD--KV-VEEaekrEV-----DLIll-tGDl------LHSRn---- 64  Thermotoga maritima
1WAO_1 255 ----------SFSVEVILT-LfgFKLLYp-----------dHF--HLLRGNHET----------D-----N-----MNQI 290 human
O13781 100 -------dltDPPGSWTDSlL--ANMDYd----------------ILVAGNHELyl-------sTva--nDty-hnFIPL 144 Schizosaccharomyces p...
P38887 110 ----------PPGLRSSEI-F--NMMDYd----------------LLTLGNHElyt------------------aeSAIL 142 Saccharomyces cerevis...
Q9US39 114 ----------PQGIYTNNI-F--TYLPYd----------------ILTIGNHElyq------------------aaISNN 146 Schizosaccharomyces p...
Q9RBM2 162 tkkcgdiygyNKEVWYADW-F--EPAKDils--------qsPF--LFVRGNHEs----------------------CDRA 206 Wolbachia sp. wRi
O13765  57 ----------DYHGISMPPkF--KRLGDffnyyn--grnkaPIltIFVGGNHEAsny-----ldElp--yGg----WVAP 111 Schizosaccharomyces p...
Q9UK59  48 ----------DLRCMAVPPkY--RHMQTfyryys--gekkaPVltLFIGGNHEAsnh-----lqElp--yGg----WVAP 102 human
Q966M6  88 ----------DLPHMSIPPkY--RSLQTfykyys--geqkaPVltLFIGGNHEasg------------------ylCELP 135 Caenorhabditis elegans
P24309  49 ----------DFKSIAIPPkY--QRLGDfisyynneieapvPT--IFIGGNHESmrhlmllphgGyvaknIfymgySNVI 114 Saccharomyces cerevis...
Q9X1X0  65 ---------nPSVVALHDL-L--DYLKRmmr--------taPV--VVLPGNHDw---------------------kGLKL 101 Thermotoga maritima
1WAO_1 291 YGFEGEV---KAKYTAqmyelF----SEVFEWLPLAQcing-----kvlIMHGglfs--------edgvTLDDIRKIERN 350 human
O13781 145 WEGRYLA---ANIDIY-----D----EHVSSFVPFGDryaifstphnvkILAFgfvn--------sfsgATDTVRVLPVS 204 Schizosaccharomyces p...
P38887 143 EYRGTSQ---SSKFKD-----K----YVCSNVEFIEDdgtrvpfgnkyiTFETpimkqrv--lalsflfSFQRANNRAIV 208 Saccharomyces cerevis...
Q9US39 147 THEYFVP---HWNGTY-----L----ASNVQIYNSSNeleqfggestyfITKHgvrtla-----mgflfNFSSNANNTVV 209 Schizosaccharomyces p...
Q9RBM2 207 YEGWFRY---LDSYPF-----Ss---EKCGNFVSSWSldagpmkffifdSSSGedifttqs-tidaferQFDKLIQNSSD 274 Wolbachia sp. wRi
O13765 112 NIYYMGR---SSVINV-----GglriAGISGIYSAMDyk---------kgRYEglpynykmlksiyhtrEFDVLSLKSLQ 174 Schizosaccharomyces p...
Q9UK59 103 NIYYLGL---AGVVKY-----RgvriGGISGIFKSHDyrkg-----hfeCPPYnssti-------rsiyHVRNIEVYKLK 162 human
Q966M6 136 NGGWVAPniyYMGFAN-----C-----IRFANLRIAGlsgifs-qgdfqFSHYerpsfse--rdvksayHVRNVDMFRLR 202 Caenorhabditis elegans
P24309 115 WFKGIRIgslSGIWKE-----W-----DFNKQRPDWNdlennnwkanirNLYHvr------------isDIAPLFMIKHR 172 Saccharomyces cerevis...
Q9X1X0 102 FGNFVTS---ISSDIT-----F----VMSFEPVDVEAkrgqkvrilpfpYPDEs-----------------EALRKNEGD 152 Thermotoga maritima
1WAO_1 351 RQppds----gpmcDLLWSD-------PQPQNGRSI------SKrgv---scQFGPDVTKAF-LEENNLDY--IIRSHEV 407 human
O13781 205 QFs----------lQPWWNDm-----vSNKDIDLILipahvpVHna----seLDIVLSELRI-HFPTTPIQ--VLGGHSH 262 Schizosaccharomyces p...
P38887 209 TPplee-----itqKSWFQNmve--tnREEEIDLIIvfghlpATdpte-remHKIHALIRKY-YPNTVIQY---FGGHTH 276 Saccharomyces cerevis...
Q9US39 210 TPvet------aikSEWYQQq-----iNRTDVDLFLlighipVRdyd---ewKSLHASIRKV-HPNTPIQI---LGGHSH 271 Schizosaccharomyces p...
Q9RBM2 275 KPmwf------lthKPLWRS---------PKKEFLTlkshgnLTqi-----eAFGD-------KFPSNVTT--IVSGHIH 325 Wolbachia sp. wRi
O13765 175 KPidi------flsHDWPRG-------IEQHGDVAKllrhkpFFrnev-ernDLGSPALEEL-LVELKPRY--WMAAHLH 237 Schizosaccharomyces p...
Q9UK59 163 QLkqpid---iflsHDWPRSiy----hYGNKKQLLKtksffrQEve----nnTLGSPAASEL-LEHLKPTY--WFSAHLH 228 human
Q966M6 203 QLksdnenkisnpiDIMLSHdwpggipDFGDKEWLFrkkdlfEAdhn---sgKLGNPSGMKL-IYDCRPRY--YLAAHLH 276 Caenorhabditis elegans
P24309 173 IDim--------lsHDWPNG-------VVYHGDTKHllklkpFFeqdi-kegKLGSPVTWQL-LRDLRPQW--WLSAHLH 233 Saccharomyces cerevis...
Q9X1X0 153 FRffle-----srlNKLYEE-------ALKKEDFAIfmghftVEglagyagiEQGREIIINRaLIPSVVDYaaL--GHIH 218 Thermotoga maritima
1WAO_1 408 K 408 human
O13781 263 I 263 Schizosaccharomyces pombe 972h-
P38887 277 I 277 Saccharomyces cerevisiae S288C
Q9US39 272 I 272 Schizosaccharomyces pombe 972h-
Q9RBM2 326 I 326 Wolbachia sp. wRi
O13765 238 T 238 Schizosaccharomyces pombe 972h-
Q9UK59 229 V 229 human
Q966M6 277 I 277 Caenorhabditis elegans
P24309 234 V 234 Saccharomyces cerevisiae S288C
Q9X1X0 219 S 219 Thermotoga maritima
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