3IAY,2GV9,4Q5V,4FVM


Conserved Protein Domain Family
DNA_pol_B

?
pfam00136: DNA_pol_B 
Click on image for an interactive view with Cn3D
DNA polymerase family B
This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.
Statistics
?
PSSM-Id: 333869
View PSSM: pfam00136
Aligned: 33 rows
Threshold Bit Score: 423.956
Threshold Setting Gi: 1169408
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3IAY_A  474 MARVTGVPFSYLLARGQQIKVVSQLFRKCLEIDTVIPnm--------------------------------------qSQ 515  baker's yeast
O48653  819 LTNISGNLWGKTLQGSRAQRVEYLLLHAFHARKFIVPdkfarskefnstkrkmnpdteaarpdeadpsiddeghhvdqGK 898  Japanese rice
P09884  768 ITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPdkqifrkpqqklg---------------dedeeidgdtnkyKK 832  human
P26019  790 ITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPdkkpvskrsgag-----------------dtdatlsgadatMQ 852  fruit fly
Q6TVU5  488 AASTYLLPQSVVFEYRASTCIKGPLMKLLLENRTVMVr----------------------------------------AD 527  Orf virus
Q9Q8R2  483 GAFTYILPQSMVFEYRASTLIKGPLLKLLLEKKIIMTr----------------------------------------SE 522  Myxoma virus
P06856  482 GASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVr----------------------------------------SE 521  Vaccinia virus WR
Q98207  479 AAATYLLPQCLALEYRASTLIKGPLLRLMLRERVVYVr----------------------------------------TQ 518  Molluscum contagios...
P21402  468 ASSTYLLPQSLALEYRASTLIKGPLLKLLLEERVIYTr----------------------------------------KI 507  Fowlpox virus strai...
4Q5V_A  433 ITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPdkqifrkpqqklg---------------dedeeidgdtnkyKK 497  human
3IAY_A  516 ASD-DQYEGATVIEPIRGYYDVPIATLDFNSLYPSIMMAHNLCYTTLCnkATv---eRLNLK-I------------DEDY 578  baker's yeast
O48653  899 TKKgPSYAGGLVLEPKKGLYDKYVLLLDFNSLYPSIIQEYNICFTTV----------------Dr-----------SADG 951  Japanese rice
P09884  833 GRKkAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTV----------------QrvaseaqkvtedGEQE 896  human
P26019  853 TKKkAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVqq--------------------------pVDAD 906  fruit fly
Q6TVU5  528 TKSkFFYEGGRVMVPKQKMHDKHVLIFDYNSLYPNVCIYANLSPETLV--GVvvsdnRLDAEvAavdvrrmfpaprYIAV 605  Orf virus
Q9Q8R2  523 KKNkYPYEGGKVFAPKQKMFINNVLIFDYNSLYPNVCLFGNLSPETLV--CVfvannKLEAEiNkqeiqkmypgprYISV 600  Myxoma virus
P06856  522 TKQkFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLV--GVvvstnRLEEEiNnqlllqkyppprYITV 599  Vaccinia virus WR
Q98207  519 EPArYTYGGGKVFLPRQKLFDTNVMVFDYNSLYPNVCIFGNLSPETLV--GVvanahRLDAEiNmqelrrrfpepaFLHV 596  Molluscum contagios...
P21402  508 TKVrYPYIGGKVFLPSQKTFENNVMIFDYNSLYPNVCIYGNLSPEKLV--CIllnsnKLESEiNmrtikskypypeYVCV 585  Fowlpox virus strai...
4Q5V_A  498 GRKkAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTV---QRvaseaQKVTE-D------------GEQE 561  human
3IAY_A  579 VITPNGD-----YFVTTKRRRGILPIILDELISARKRAKKDLRDEK-DpFK-RDVLNGRQLALKISANSVYGFTGATVGK 651  baker's yeast
O48653  952 NVP---------NLPASKT-TGVLPELLKSLVERRRMVKSWLKTAS-GlK--RQQFDIQQQALKLTANSMYGCLGFSNSR 1018 Japanese rice
P09884  897 QIP---------ELPDPSLEMGILPREIRKLVERRKQVKQLMKQQD-LnPDlILQYDIRQKALKLTANSMYGCLGFSYSR 966  human
P26019  907 ELP---------TLPDSKTEPGILPLQLKRLVESRKEVKKLMAAPD-LsPElQMQYHIRQMALKLTANSMYGCLGFAHSR 976  fruit fly
Q6TVU5  606 PCEPRSPelvaeVAIFDREAKGIIPMLLRSFLDARAKYKKLMKAAE-TaVD-REIYNSMQYTYKITANSVYGLMGFRNSA 683  Orf virus
Q9Q8R2  601 QCEPRSEdlvseIAVFDRSVEGIIPKLLKTFLTERLKYKKMIKETN-DvVE-KAIYDSMQYTYKIIANSVYGLMGFKNSA 678  Myxoma virus
P06856  600 HCEPRLPnliseIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQAT-SsTE-KAIYDSMQYTYKIVANSVYGLMGFRNSA 677  Vaccinia virus WR
Q98207  597 LCEARARdgyseIAVFDRRRQGIIPKLLGTFMEQRARYKALMRAAS-SgLE-RTLYDSMQYVYKVVANSVYGLMGFYNSS 674  Molluscum contagios...
P21402  586 SCESRLSdyyseIIVYDRREKGIIPKLLEMFIGKRKEYKNLLKTAS-TtIE-STLYDSLQYIYKIIANSVYGLMGFSNST 663  Fowlpox virus strai...
4Q5V_A  562 QIP---------ELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDlNpDL-ILQYDIRQKALKLTANSMYGCLGFSYSR 631  human
3IAY_A  652 LPCLAISSSVTAYGRTMILKTKTAVQEKYCikng-----------------------------------ykhdAVVVYGD 696  baker's yeast
O48653 1019 FYAKPLAELITLQGREILQNTVDLVQNNLN-------------------------------------------LEVIYGD 1055 Japanese rice
P09884  967 FYAKPLAALVTYKGREILMHTKEMVQKMN--------------------------------------------LEVIYGD 1002 human
P26019  977 FFAQHLAALVTHKGREILTNTQQLVQKMN--------------------------------------------YDVVYGD 1012 fruit fly
Q6TVU5  684 LFSYASAKSCTAIGRTMIAYLERTLDGASVcgtrlslaaapdnpllrdeafagraaeleidaavagertervgFRSVYGD 763  Orf virus
Q9Q8R2  679 LYSYASAKSCTAIGRQMIHYLNSVLNGCKLssgkfqlaaypinpffqdd------rsvdlyastnlpteynydFKGVYGD 752  Myxoma virus
P06856  678 LYSYASAKSCTSIGRRMILYLESVLNGAELsngmlrfanplsnpfymdd------rdinpivktslpidyrfrFRSVYGD 751  Vaccinia virus WR
Q98207  675 LYSYSSAKCCTTIGRVMITYLDRVVDGATLcagvlrlaaeprnpllasap----prardvdvsaalghelelrFRSVYGD 750  Molluscum contagios...
P21402  664 LYSYSSAKTCTTIGRNMITYLDSIMNGAVWendkliladfprnifsge--------tmfnkelevpnmnesfkFRSVYGD 735  Fowlpox virus strai...
4Q5V_A  632 FYAKPLAALVTYKGREILMHTKEMVQKMN--------------------------------------------LEVIYGD 667  human
3IAY_A  697 TDSVMVKFGTTDLKEAMDLGTEAAKYVST-LFKHPINLEFEKAYFPYLLINKKRYAGLFWTnpdkfD----K-LDQKGLA 770  baker's yeast
O48653 1056 TDSIMIHTGLDDISRAKGIAGKVIQEVNK--KYRCLEIDLDGIYKRMLLLKKKKYAAIKVAldgslR----EnIERKGLD 1129 Japanese rice
P09884 1003 TDSIMINTNSTNLEEVFKLGNKVKSEVNK--LYKLLEIDIDGVFKSLLLLKKKKYAALVVEptsdgNyvtkQ--ELKGLD 1078 human
P26019 1013 TDSLMINTNITDYDQVYKIGHNIKQSVNK--LYKQLELDIDGVFGCLLLLKKKKYAAIKLSkdskgNlrreQ--EHKGLD 1088 fruit fly
Q6TVU5  764 TDSVFLEVGASDIAFSRRVGRCLERVINEhVLFANFKVEFEAVYCNLIMQSKKKYTTIKFAvsdggGs--eR--VSKGTS 839  Orf virus
Q9Q8R2  753 TDSVFLEINTNDVLTSIKIAKELERVINTkVLFDNFKIEFEAVYKNLIMQSKKKYTTLKYVpsstqNsipvR--INKGTS 830  Myxoma virus
P06856  752 TDSVFTEIDSQDVDKSIEIAKELERLINNrVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSassnsKsvpeR--INKGTS 829  Vaccinia virus WR
Q98207  751 TDSIFLELNLREVQTTLAVARTLERVLNEhVLFENFRVEFEAIYQNLILQSKKKYSTTKYAadhraGdapeH--VSKGTS 828  Molluscum contagios...
P21402  736 TDSIFSEISTKDIEKTAKIAKHLEHIINTkILHANFKIEFEAIYTQLILQSKKKYTTIKYLanykpGdkpiR--VNKGTS 813  Fowlpox virus strai...
4Q5V_A  668 TDSIMINTNSTNLEEVFKLGNKVKSEVNK--LYKLLEIDIDGVFKSLLLLKKKKYAALVVEptsdgNyv-tK-QELKGLD 743  human
3IAY_A  771 SVRRDSCSLVSIVM---NKVLKKILIER--NVDGALAFVRETI-----NDILHNRVDISKLIISKTLa---pNYTNPQ-- 835  baker's yeast
O48653 1130 MVRRDWSLLSKEIG---DFCLNQILSGG--SCDDVIESIHSSLvq-vqEQMRGGQTELEKYIITKSLtkapeDYPDAKnq 1203 Japanese rice
P09884 1079 IVRRDWCDLAKDTG---NFVIGQILSDQ--SRDTIVENIQKRLie-igENVLNGSVPVSQFEINKALtkdpqDYPDKKsl 1152 human
P26019 1089 IVRRDWSQLAVMVG---KAVLDEVLSEK--PLEEKLDAVHAQLek-ikTQIAEGVVPLPLFVITKQLtrtpqEYANSAsl 1162 fruit fly
Q6TVU5  840 ETRRDVAPFHKLMIrkyKDMLCRALAEE--GSGNVGVEILRSLedeltFEFEARSMPLDWFLLSRTHh---kNFKSPDn- 913  Orf virus
Q9Q8R2  831 ETRRDVSKFHKYMIkiyKTRILEMLSDGtsSSLQVCINILKSLesdllIEFETRKAPLDLFLLSRTHh---cNYKSIDn- 906  Myxoma virus
P06856  830 ETRRDVSKFHKNMIktyKTRLSEMLSEGrmNSNQVCIDILRSLetdlrSEFDSRSSPLELFMLSRMHh---sNYKSADn- 905  Vaccinia virus WR
Q98207  829 ETRRDVSRFHKLMIsryKAQLVALLAEArlSSRQVCIEMLRSLevdlfAEFAARAQPLEMFLLSRMHh---rNYKAPDn- 904  Molluscum contagios...
P21402  814 ETRRDVALFHKHMIqryKDMLMKLLMESk-GQQEITRLILQSLetdmiSEFTHNR-EFEKYLLSRKHh---nNYKSATh- 887  Fowlpox virus strai...
4Q5V_A  744 IVRRDWCDLAKDTG---NFVIGQILSDQ--SRDTIVENIQKRLie-igENVLNGSVPVSQFEINKALtkdpqDYPDKKsl 817  human
3IAY_A  836 PHAVLAERMKRREGVGPNVGDRVDYVII----------GGNDKLYNRAEDPLFVLE-NN--IQVDSRYYLTnQLQNPIIS 902  baker's yeast
O48653 1204 PHVQVALRLKQNGYSGCSAGDTVPYIICsqqd---sesTHSGGIAQRARHPEELKRnPDk-WMIDIDYYLSqQIHPVVSR 1279 Japanese rice
P09884 1153 PHVHVALWINSQGGRKVKAGDTVSYVICq--------dGSNLTASQRAYAPEQLQKqDN--LTIDTQYYLAqQIHPVVAR 1222 human
P26019 1163 PHVQVALRMNRERNRRYKKGDMVDYVICl--------dGTTNAAMQRAYHLDELKTsEDkkLQLDTNYYLGhQIHPVVTR 1234 fruit fly
Q6TVU5  914 PNVALVTRYNAANAEAIEIGERYFFAYVceegp-wrrrIANVKSYERVVDKTFKLDkNE---RIMYEVYFK-RLCTEIVN 988  Orf virus
Q9Q8R2  907 PNMYLVNEYNKNNPERIEIGERYYFAYLcdakdawqkkLVNIKTYERIIDKGFTLGsTD---RIFYEVYFK-RLATEVVN 982  Myxoma virus
P06856  906 PNMYLVTEYNKNNPETIELGERYYFAYIcpanvpwtkkLVNIKTYETIIDRSFKLGsDQ---RIFYEVYFK-RLTSEIVN 981  Vaccinia virus WR
Q98207  905 PNVELVNRYNRENLEPIELGERYYYAYVcaselpwqlaVANVRNHERIVDASYVLPeRE---RVFYEIYFR-RLATELVN 980  Molluscum contagios...
P21402  888 SNFELVKRYNLENTEKIEIGERYYYIYIcdislpwqkkLCNILSYEVIADSKFYLPkDK---RIFYEIYFK-RIASEVVN 963  Fowlpox virus strai...
4Q5V_A  818 PHVHVALWINSQGGRKVKAGDTVSYVICq--------dGSNLTASQRAYAPEQLQKqDN--LTIDTQYYLAqQIHPVVAR 887  human
3IAY_A  903 IVAPI 907  baker's yeast
O48653 1280 LCASI 1284 Japanese rice
P09884 1223 ICEPI 1227 human
P26019 1235 MVEVL 1239 fruit fly
Q6TVU5  989 LLDnk 993  Orf virus
Q9Q8R2  983 LLDnk 987  Myxoma virus
P06856  982 LLDnk 986  Vaccinia virus WR
Q98207  981 LLDnk 985  Molluscum contagiosum virus subtype 1
P21402  964 LLTdk 968  Fowlpox virus strain NVSL
4Q5V_A  888 ICEPI 892  human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap