4FVM,5EXR,3IAY


Conserved Protein Domain Family
DNA_pol_B

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pfam00136: DNA_pol_B 
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DNA polymerase family B
This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.
Statistics
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PSSM-Id: 395085
View PSSM: pfam00136
Aligned: 29 rows
Threshold Bit Score: 415.472
Threshold Setting Gi: 1169408
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FVM_A  435 NAWAQTLGGTRAGRNEYILLHEFSRNGFIVPd-------KEGNrSRAQkqrqneena-------------dapvnskkAk 494  Saccharomyces cerev...
Q6TVU5  494 LPQSVVFEYRASTCIKGPLMKLLLENRTVMV--------RADTkSKFF-------------------------------- 533  Orf virus
P06856  488 LPQSMVFEYRASTVIKGPLLKLLLETKTILV--------RSETkQKFP-------------------------------- 527  Vaccinia virus WR
Q9Q8R2  489 LPQSMVFEYRASTLIKGPLLKLLLEKKIIMT--------RSEKkNKYP-------------------------------- 528  Myxoma virus
Q98207  485 LPQCLALEYRASTLIKGPLLRLMLRERVVYV--------RTQEpARYT-------------------------------- 524  Molluscum contagios...
P21402  474 LPQSLALEYRASTLIKGPLLKLLLEERVIYT--------RKITkVRYP-------------------------------- 513  Fowlpox virus strai...
5EXR_G  440 NIMSRTLMGGRSERNEFLLLHAFYENNYIVPdkqi-frkPQQKlGDEDeeidgdtn--------------kykkgrkkAa 504  human
P26019  796 NTMTRTLQGGRSERNEFLLLHAFHEKNYIVPdkk--pvsKRSGaGDTDatlsgada---------------tmqtkkkAa 858  fruit fly
O48653  825 NLWGKTLQGSRAQRVEYLLLHAFHARKFIVPdkfarskeFNSTkRKMNpdteaarpdeadpsiddeghhvdqgktkkgPs 904  Japanese rice
Q57UW4  676 NLWSRTLYGARSERIEYLLLHAFHNLKFVTPdk----kkRDLKrGREDddde----------------------gkrkTk 729  Trypanosoma brucei
4FVM_A  495 YQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDID--ELPS--------------------VPP-- 550  Saccharomyces cerev...
Q6TVU5  534 YEGGRVMVPKQKMHDKHVLIFDYNSLYPNVCIYANLSPETLVGVVVSDN--RLDAevaavdvrrmfpapryiavpCEPrs 611  Orf virus
P06856  528 YEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTN--RLEEeinnqlllqkypppryitvhCEPrl 605  Vaccinia virus WR
Q9Q8R2  529 YEGGKVFAPKQKMFINNVLIFDYNSLYPNVCLFGNLSPETLVCVFVANN--KLEAeinkqeiqkmypgpryisvqCEPrs 606  Myxoma virus
Q98207  525 YGGGKVFLPRQKLFDTNVMVFDYNSLYPNVCIFGNLSPETLVGVVANAH--RLDAeinmqelrrrfpepaflhvlCEAra 602  Molluscum contagios...
P21402  514 YIGGKVFLPSQKTFENNVMIFDYNSLYPNVCIYGNLSPEKLVCILLNSN--KLESeinmrtikskypypeyvcvsCESrl 591  Fowlpox virus strai...
5EXR_G  505 YAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQ--KVTEdgeq------------eqipELPd- 569  human
P26019  859 YAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADElpTLPD------------------------- 913  fruit fly
O48653  905 YAGGLVLEPKKGLYDKYVLLLDFNSLYPSIIQEYNICFTTVDRSADGNVp-NLP-------------------------- 957  Japanese rice
Q57UW4  730 YQGGMVLEPKSGLYSEYILLLDFNSLYPSLIQEFNVCYTTIDRDENTVSa-EVPPpesl------------iclsCRAag 796  Trypanosoma brucei
4FVM_A  551 ----------SEVDQGVLPRLLANLVDRRREVKKVMK-TETDPhKRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLA 619  Saccharomyces cerev...
Q6TVU5  612 pelvaevaifDREAKGIIPMLLRSFLDARAKYKKLMK-AAETAvDREIYNSMQYTYKITANSVYGLMGFRNSALFSYASA 690  Orf virus
P06856  606 pnliseiaifDRSIEGTIPRLLRTFLAERARYKKMLK-QATSStEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASA 684  Vaccinia virus WR
Q9Q8R2  607 edlvseiavfDRSVEGIIPKLLKTFLTERLKYKKMIK-ETNDVvEKAIYDSMQYTYKIIANSVYGLMGFKNSALYSYASA 685  Myxoma virus
Q98207  603 rdgyseiavfDRRRQGIIPKLLGTFMEQRARYKALMR-AASSGlERTLYDSMQYVYKVVANSVYGLMGFYNSSLYSYSSA 681  Molluscum contagios...
P21402  592 sdyyseiivyDRREKGIIPKLLEMFIGKRKEYKNLLK-TASTTiESTLYDSLQYIYKIIANSVYGLMGFSNSTLYSYSSA 670  Fowlpox virus strai...
5EXR_G  570 ----------PSLEMGILPREIRKLVERRKQVKQLMKqQDLNPdLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLA 639  human
P26019  914 ----------SKTEPGILPLQLKRLVESRKEVKKLMAaPDLSPeLQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLA 983  fruit fly
O48653  958 ----------ASKTTGVLPELLKSLVERRRMVKSWLK-TASGL-KRQQFDIQQQALKLTANSMYGCLGFSNSRFYAKPLA 1025 Japanese rice
Q57UW4  797 l-------psPCLHKCILPKVIRGLVDSRREIKRMMK-SERDPgNLAMLEIRQLALKLTANSMYGCLGFEYSRFYAQPLA 868  Trypanosoma brucei
4FVM_A  620 MLVTNKGREILMNTRQLAES-------------------------------------------M-NLLVVYGDTDSVMID 655  Saccharomyces cerev...
Q6TVU5  691 KSCTAIGRTMIAYLERTLDgasvcgtrlslaaapdnpllrdeafagraaeleidaavagertervGFRSVYGDTDSVFLE 770  Orf virus
P06856  685 KSCTSIGRRMILYLESVLNgaelsngmlrfanplsnpfy------mddrdinpivktslpidyrfRFRSVYGDTDSVFTE 758  Vaccinia virus WR
Q9Q8R2  686 KSCTAIGRQMIHYLNSVLNgcklssgkfqlaaypinpff------qddrsvdlyastnlpteynyDFKGVYGDTDSVFLE 759  Myxoma virus
Q98207  682 KCCTTIGRVMITYLDRVVDgatlcagvlrlaaeprnplla----sapprardvdvsaalghelelRFRSVYGDTDSIFLE 757  Molluscum contagios...
P21402  671 KTCTTIGRNMITYLDSIMNgavwendkliladfprnif--------sgetmfnkelevpnmnesfKFRSVYGDTDSIFSE 742  Fowlpox virus strai...
5EXR_G  640 ALVTYKGREILMHTKEMVQK-------------------------------------------M-NLEVIYGDTDSIMIN 675  human
P26019  984 ALVTHKGREILTNTQQLVQK-------------------------------------------M-NYDVVYGDTDSLMIN 1019 fruit fly
O48653 1026 ELITLQGREILQNTVDLVQN-------------------------------------------NlNLEVIYGDTDSIMIH 1062 Japanese rice
Q57UW4  869 ELVTRQGRLALQNTVELIPQis------------------------------------------pSIRVIYGDTDSVMIQ 906  Trypanosoma brucei
4FVM_A  656 TGC-DNYADAIKIGLGFKRLVNE-RYRL-LEIDIDNVFKKLLLHAKKKYAALTVNldkngNgt-tV-LEVKGLDMKRREF 730  Saccharomyces cerev...
Q6TVU5  771 VGA-SDIAFSRRVGRCLERVINEhVLFAnFKVEFEAVYCNLIMQSKKKYTTIKFAvsdggG----SeRVSKGTSETRRDV 845  Orf virus
P06856  759 IDS-QDVDKSIEIAKELERLINNrVLFNnFKIEFEAVYKNLIMQSKKKYTTMKYSassnsKsvpeR--INKGTSETRRDV 835  Vaccinia virus WR
Q9Q8R2  760 INT-NDVLTSIKIAKELERVINTkVLFDnFKIEFEAVYKNLIMQSKKKYTTLKYVpsstqNsipvR--INKGTSETRRDV 836  Myxoma virus
Q98207  758 LNL-REVQTTLAVARTLERVLNEhVLFEnFRVEFEAIYQNLILQSKKKYSTTKYAadhraGdapeH--VSKGTSETRRDV 834  Molluscum contagios...
P21402  743 IST-KDIEKTAKIAKHLEHIINTkILHAnFKIEFEAIYTQLILQSKKKYTTIKYLanykpGdkpiR--VNKGTSETRRDV 819  Fowlpox virus strai...
5EXR_G  676 TNS-TNLEEVFKLGNKVKSEVNK-LYKL-LEIDIDGVFKSLLLLKKKKYAALVVEptsdgNyv-tK-QELKGLDIVRRDW 750  human
P26019 1020 TNI-TDYDQVYKIGHNIKQSVNK-LYKQ-LELDIDGVFGCLLLLKKKKYAAIKLSkdskgNlr-rE-QEHKGLDIVRRDW 1094 fruit fly
O48653 1063 TGL-DDISRAKGIAGKVIQEVNK-KYRC-LEIDLDGIYKRMLLLKKKKYAAIKVAldgslR----EnIERKGLDMVRRDW 1135 Japanese rice
Q57UW4  907 TGIkDDIGKVRNLGFEIKGKVNQ-RYQS-LELDIDGVFRAMLLLRKKKYAALSVVdwqgeGkvykR--EVKGLDMVRRDW 982  Trypanosoma brucei
4FVM_A  731 CPLSRDVSIHVLNTILSD------KDPEEALQEVYDYLEDIR-IKVETNNI-RIDKYKINMKLSKDPKAYpGGKNMPAVQ 802  Saccharomyces cerev...
Q6TVU5  846 APFHKLMIRKYKDMLCRAla--eeGSGNVGVEILRSLEDELT-FEFEARSM-PLDWFLLSRTHHK---NF-KSPDNPNVA 917  Orf virus
P06856  836 SKFHKNMIKTYKTRLSEMlsegrmNSNQVCIDILRSLETDLR-SEFDSRSS-PLELFMLSRMHHS---NY-KSADNPNMY 909  Vaccinia virus WR
Q9Q8R2  837 SKFHKYMIKIYKTRILEMlsdgtsSSLQVCINILKSLESDLL-IEFETRKA-PLDLFLLSRTHHC---NY-KSIDNPNMY 910  Myxoma virus
Q98207  835 SRFHKLMISRYKAQLVALlaearlSSRQVCIEMLRSLEVDLF-AEFAARAQ-PLEMFLLSRMHHR---NY-KAPDNPNVE 908  Molluscum contagios...
P21402  820 ALFHKHMIQRYKDMLMKLlm--esKGQQEITRLILQSLETDMiSEFTHNR--EFEKYLLSRKHHN---NY-KSATHSNFE 891  Fowlpox virus strai...
5EXR_G  751 CDLAKDTGNFVIGQILSD------QSRDTIVENIQKRLIEIG-ENVLNGSV-PVSQFEINKALTKDPQDYpDKKSLPHVH 822  human
P26019 1095 SQLAVMVGKAVLDEVLSE------KPLEEKLDAVHAQLEKIK-TQIAEGVV-PLPLFVITKQLTRTPQEYaNSASLPHVQ 1166 fruit fly
O48653 1136 SLLSKEIGDFCLNQILSG------GSCDDVIESIHSSLVQVQ-EQMRGGQT-ELEKYIITKSLTKAPEDYpDAKNQPHVQ 1207 Japanese rice
Q57UW4  983 CPLSQHVSDAVLKRILNA------EGGEDILDFVIKYMKGVA-QDVRSGNVyPLEEFVISKSLTKEPESY-HGTGYPHAV 1054 Trypanosoma brucei
4FVM_A  803 VALRMRKA-GRVVKAGSVITFVITKQDEidnaadtpALSVAERAHALnEVMIK---SNnLIPDPQYYLEkQIFAPVERLL 878  Saccharomyces cerev...
Q6TVU5  918 LVTRYNAAnAEAIEIGERYFFAYVCE-EgpwrrriaNVKSYERVVDK-TFKLD---KN-ERIMYEVYFK-RLCTEIVNLL 990  Orf virus
P06856  910 LVTEYNKNnPETIELGERYYFAYICPANvpwtkklvNIKTYETIIDR-SFKLG---SD-QRIFYEVYFK-RLTSEIVNLL 983  Vaccinia virus WR
Q9Q8R2  911 LVNEYNKNnPERIEIGERYYFAYLCDAKdawqkklvNIKTYERIIDK-GFTLG---ST-DRIFYEVYFK-RLATEVVNLL 984  Myxoma virus
Q98207  909 LVNRYNREnLEPIELGERYYYAYVCASElpwqlavaNVRNHERIVDA-SYVLP---ER-ERVFYEIYFR-RLATELVNLL 982  Molluscum contagios...
P21402  892 LVKRYNLEnTEKIEIGERYYYIYICDISlpwqkklcNILSYEVIADS-KFYLP---KD-KRIFYEIYFK-RIASEVVNLL 965  Fowlpox virus strai...
5EXR_G  823 VALWINSQgGRKVKAGDTVSYVICQDGS--------NLTASQRAYAPeQLQKQ---DN-LTIDTQYYLAqQIHPVVARIC 890  human
P26019 1167 VALRMNRErNRRYKKGDMVDYVICLDGT--------TNAAMQRAYHL-DELKTsedKK-LQLDTNYYLGhQIHPVVTRMV 1236 fruit fly
O48653 1208 VALRLKQNgYSGCSAGDTVPYIICSQQDses---thSGGIAQRARHPeELKRN---PDkWMIDIDYYLSqQIHPVVSRLC 1281 Japanese rice
Q57UW4 1055 VALRMKQRk-EGVRVGDLIPYVICEG----------DEHIDDKAYHIdEVRRS---DG-LSVDVEWYLSsQLYPPVMRLC 1119 Trypanosoma brucei
4FVM_A  879 ERI 881  Saccharomyces cerevisiae S288C
Q6TVU5  991 Dnk 993  Orf virus
P06856  984 Dnk 986  Vaccinia virus WR
Q9Q8R2  985 Dnk 987  Myxoma virus
Q98207  983 Dnk 985  Molluscum contagiosum virus subtype 1
P21402  966 Tdk 968  Fowlpox virus strain NVSL
5EXR_G  891 EPI 893  human
P26019 1237 EVL 1239 fruit fly
O48653 1282 ASI 1284 Japanese rice
Q57UW4 1120 EHI 1122 Trypanosoma brucei
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