1VYW


Conserved Protein Domain Family
Cyclin_N

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pfam00134: Cyclin_N 
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Cyclin, N-terminal domain
Cyclins regulate cyclin dependent kinases (CDKs). Cyclin-0 (CCNO) is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.
Statistics
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Aligned: 96 rows
Threshold Bit Score: 60.9897
Threshold Setting Gi: 75278850
Created: 19-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VYW_B  14 DIHTYLREMEVk--CKPKVGYM--KKQPDit----nsMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLS-SM-SVLR 83  human
Q12477  19 EMIQFLATSTAsiiKIRENNNPiqGCRP-----------PDLSIFIKNVVIQSNVQTPTLMATSVYLNKLKS----VIPK 83  Saccharomyces cerevis...
O80513  23 RVAESNDLTRRvatQSQRVSVFhgLSRPT----------ITIQSYLERIFKYANCSPSCFVVAYVYLDRFTH-RQpSLPI 91  thale cress
Q9VKF0 205 DIFD------------EKLHPLthDQVPDnydthnpeHRQ-IYKFVRTLFNAAQLTAECAIITLVYLERLLTyAElDVGP 271 fruit fly
P42751  50 DSIACFIEDERh--FVPGHDYLsrFQTRSld----asAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLY-AR-RLPE 121 thale cress
P42752  65 DRIKEMLVREIe--FCPGTDYVkrLLSGDld----lsVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLT-SY-ELPK 136 thale cress
Q8LGA1  45 EIIMEMVEKEKq--HLPSDDYIkrLRSGDldl---nvGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLS-VH-DLPS 117 thale cress
Q9SMD4  51 EELTSLFSKETe--YEISYNVLe----kNqsf---isSRRESVEWILKTTAYYSFSAQTGFLAVNYFDRFLL--F-SFNQ 118 tomato
Q9S7H9  61 DELATLLSKENe--FHLGFQSLi----sDgsl---mgARKEALDWMLRVIAYYGFTATTAVLAVNYFDRFVS-GW-CFQK 129 tomato
Q9SN11  59 DELSTLISKQE--------PCLydEILDDefl---vlCREKALDWIFKVKSHYGFNSLTALLAVNYFDRFIT-SR-KFQT 125 thale cress
1VYW_B  84 G------KLQLVGTAAMLLASKFEEIyPPEVAEFVYITD----D--TYTKKQVLRMEHLVLKVLTFDLA 140 human
Q12477  84 NvygintTRHRIFLGCLILAAKTLNDsSPWNKHWTTYTE----G--LLRIREVNTIERELLEYLNWDVR 146 Saccharomyces cerevisiae S288C
O80513  92 Ns----fNVHRLLITSVMVAAKF-------LDDLYYNNayya-kvgGISTKEMNFLELDFLFGLGFELN 148 thale cress
Q9VKF0 272 C------NWKRMVLGAILLASKV-------WDDQAVWNvdycqilkDITVEDMNELERQFLELLQFNIN 327 fruit fly
P42751 122 Tsg---wPMQLLAVACLSLAAKMEEIlVPSLFDFQVA-G----VkyLFEAKTIKRMELLVLSVLDWRLR 182 thale cress
P42752 137 Dkd---wAAQLLAVSCLSLASKMEETdVPHIVDLQVE-D----PkfVFEAKTIKRMELLVVTTLNWRLQ 197 thale cress
Q8LGA1 118 Gkg---wILQLLAVACLSLAAKIEETeVPMLIDLQVG-D----PqfVFEAKSVQRMELLVLNKLKWRLR 178 thale cress
Q9SMD4 119 SlnhkpwMNQLVAVTCLSLAAKVEETdVPLLLDLQVE-E----SgfLFESKTIQRMEMLILSTLKWKMN 182 tomato
Q9S7H9 130 Dkp---wMSQLAAVACLSIAAKVEETqVPLLLDLQVA-D----SrfVFEAKTIQRMELLVLSTLKWKMN 190 tomato
Q9SN11 126 Dkp---wMSQLTALACLSLAAKVEEIrVPFLLDFQVE-E----AryVFEAKTIQRMELLVLSTLDWRMH 186 thale cress
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