1QU2


Conserved Protein Domain Family
tRNA-synt_1

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pfam00133: tRNA-synt_1 
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tRNA synthetases class I (I, L, M and V)
Other tRNA synthetase sub-families are too dissimilar to be included.
Statistics
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PSSM-Id: 306611
View PSSM: pfam00133
Aligned: 13 rows
Threshold Bit Score: 806.25
Threshold Setting Gi: 2507438
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A         26 QIQEKWDAEDQ-YHKAleKNKG-NET--FILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPI 101
gi 251757438   20 DRYDFWLKGKF-FEAG--SDQT-KEP--YSVVIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIAT 93
gi 122263839   18 gRYQEWLDEDV-FKPS--GDQK-AKP--YSIVIPPPNVTGKLHMGHAWDTTLQDIVIREKRMQGFDTLWLPGMDHAGIAT 91
gi 2507438     13 PLYEHWEKQGY-FKPN---GDEsQES--FCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIAT 86
gi 1174549     19 ALYQRWEESGY-FKPS---ENEnAPS--YCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGHNTLWQTGTDHAGIAT 92
gi 135184     148 AWYQWWEKAGY-FKPEs-CRKPsAGK--FVIPLPPPNVTGALHCGHALANSLQDTLIRWYRMKGYETLWVPGCDHAGIST 223
gi 1711655    156 SWYDWWIKTGV-FEPEftADGKvKPEgvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIAT 234
gi 239938717   17 KILEFWTEFNC-FQEClkQSKH-KPK--FTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
gi 123407059   26 QIQEKWDAEDQ-YHKAleKNKG-NET--FILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPI 101
gi 12644012    26 QRFKKWFEQNYaYEKMkeNRKNaKKS--FTLHDGPPYANGHIHIGHALNKILKETIIKTHYFKGESVRFTPGWDCHGLPI 103
gi 2507434     27 GMLARWTDDDL-YGIIraAKKG-KKT--FILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPI 102
gi 829189179   42 nILKFWDEINA-FKQQleKTKD-CPP--FTFYDGPPFATGLPHYGNLLAGTIKDVVCRYASQNGKYVERRFGWDCHGLPV 117
gi 135134      16 KVLSLWDEIDA-FHTSleLTKD-KPE--FSFFDGPPFATGTPHYGHILASTIKDIVPRYATMTGHHVERRFGWDTHGVPI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        102 EQALTKK-----GVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLI 176
gi 251757438   94 QAKVEAKlr-eeGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVREVFVKLYEKGLI 172
gi 122263839   92 QAKVEAKlr-keGISRYDLGRDKFVQKVWEWKDEFAKTIHSQWAKMGLSLDYSRERFTLDKGLNEAVRKVFVELYKQGLI 170
gi 2507438     87 QMVVERKiaaeeGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLI 166
gi 1174549     93 QMVVERKiaaeeGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWERERFTMDDGLSNAVKEVFVRLHEEGLI 172
gi 135184     224 QSVVEKMlwkkeKKIRQELGREKFTDLVWEWKGEYHQRINNAQKLMGGSMDWSREAFTMDKNLTAATMETFCRLHDEGLI 303
gi 1711655    235 QSVVEKQiwakdRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVI 314
gi 239938717   93 EYEIDKTlgirgPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
gi 123407059  102 EQALTKKgv-----drKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLI 176
gi 12644012   104 EQQVEVKlgekkK----SLSKKEIREFCRQHASEFVDIQREEFKDLGIIADWDKPYLTMKFEFEAAIYRTLCEIAKKGLL 179
gi 2507434    103 ELKVEQEygkpgE----KFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHL 178
gi 829189179  118 EYEIDKKlgitnRQEVLKMGVDKYNAECRSIVMRYAQEWRSIVNRFGRWVDFDNDYKTLDLKFMESVWWVFKQMFDKGLV 197
gi 135134      92 EHIIDKKlgitgKDDVFKYGLENYNNECRSIVMTYASDWRKTIGRLGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        177 YKGKKPVYWSPSSESSLAEAEI--EYHDKR----------------SASIYVAFNV------KDDKGvvd--adaKFIIW 230
gi 251757438  173 YRGEYIINWDPATKTALSDIEV--IYKDVQ----------------GAFYHMSYPL------ADGSG--------SIEIA 220
gi 122263839  171 YRGEYIVNWDPQARTALSDIEV--IHEDDK----------------GAFYHVKYPF------ADGSG--------YIEIA 218
gi 2507438    167 YRGKRLVNWDPKLRTAISDLEV--ENRESK----------------GSMWHIRYPLadgaktADGKD--------YLVVA 220
gi 1174549    173 YRGKRLVNWDPKLHTAISDLEV--ENKESK----------------GSLWHFRYPLandaktADGKD--------YLVVA 226
gi 135184     304 YRSNRLVNWCTHLNTALSGLEV--ETKEITgrtlldvpgydkkvefGVLTHFKYQI------DGSEE--------TIEVA 367
gi 1711655    315 YRASRLVNWSVKLNTAISNLEV--ENKDVKsrtllsvpgydekvefGVLTSFAYPV------IGSDE--------KLIIA 378
gi 239938717  173 YRGVKVMPFSTACNTPLSNFEShqNYKDVQ----------------DPSVFVTFPL------EEDETv-------SLVAW 223
gi 123407059  177 YKGKKPVYWSPSSESSLAEAEI--EYHDKR----------------SASIYVAFDV------KDDKGvvd--adaKFIIW 230
gi 12644012   180 CERSKPVFWSWAAKSALAEAEV--EYQDKE----------------DYSIFVAFDL------DVKACeklgvskaSAVIW 235
gi 2507434    179 HKGAKPVHWCVDCRSALAEAEV--EYYDKT----------------SPSIDVAFQAvdqdalKAKFAvsnvngpiSLVIW 240
gi 829189179  198 YRGCKVMPYSNGCATVLSNFETqqNYKEVD----------------DPSLFIAFKT------AEDPKt-------KFIAW 248
gi 135134     172 YRGFKVMPYSTGLTTPLSNFEAqqNYKDVN----------------DPAVTIGFNV------IGQEKt-------QLVAW 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        231 TTTPWTIPSNVAITVHPElkygqynvngekyiiaealsdavaealdwdkasiklekEYTGKELEWVVAQHPF-------L 303
gi 251757438  221 TTRPETMLGDTAVAVHPE--------------------------------------DERYKHLIGKTVILPI-------V 255
gi 122263839  219 TTRPETMMGDTAVAVHPG--------------------------------------DKRYQDLVGKELILPL-------A 253
gi 2507438    221 TTRPETLLGDTGVAVNPE--------------------------------------DPRYKDLIGKYVILPL-------V 255
gi 1174549    227 TTRPETMLGDTAVAVHPE--------------------------------------DERYQSLIGKTVVLPL-------A 261
gi 135184     368 TTRPETMLGDTGIAVNPE--------------------------------------DPRYTHLVGKFARHPF-------V 402
gi 1711655    379 TTRPETIFGDTAVAVHPD--------------------------------------DDRYKHLHGKFIQHPF-------L 413
gi 239938717  224 TTTPWTLPSNLAVCVNPEmqyvkikdvargrllilm--earlsalyklesdyeileRFPGAYLKGKKYRPLFdyflkckE 301
gi 123407059  231 TTTPWTIPSNVAITVHPElkygqynvngekyiiaealsdavaealdwdkasiklekEYTGKELEYVVAQHPF-------L 303
gi 12644012   236 TTTPWTLVANQAIALNPNenyvitkeglifasal------lksmvekgltsgeiqkELNAKEFEKLEAINPL-------N 302
gi 2507434    241 TTTPWTLPANRAISIAPDfdyalvqidgqavilakd--lvesvmqrigvtdytilgTVKGAELELLRFTHPF-------M 311
gi 829189179  249 TTTPWTLPSNLALVINKDfdyvkvldaktqehyilae-crlpelykkdkdgykileKFKGSELVGREYEPLFpyflsrkQ 327
gi 135134     223 TTTPWTLPSNLSLCVNADfeyvkiydetrdryfillesliktlykkpknekykiveKIKGSDLVGLKYEPLFpyfaeqfH 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        304 DRESLVING-DHVTTDAGTGCVHTAPGHGEDDYIVGQQYEL-----PVISPIDDKGVFTEEG------------------ 359
gi 251757438  256 NREIPIVGD-DYVDMEFGSGAVKITPAHDPNDFELGNRHNL-----ERILVMNEDGTMNENA------------------ 311
gi 122263839  254 NRKIPIIED-AYVDPAFGTGAVKITPAHDPNDFQVGNRHDL-----KRINTMNEDGTMNENA------------------ 309
gi 2507438    256 NRRIPIVGD-EHADMEKGTGCVKITPAHDFNDYEVGKRHAL-----PMINILTFDGDIRESAqvfdtkgnesdvysseip 329
gi 1174549    262 NREIPIIAD-EYVDREFGTGVVKITPAHDFNDYEVGKRHNL-----PMVNVLTLNANIRDEAeiigtdgkplagyeatip 335
gi 135184     403 DRLLPIVTD-NYVDKEFGTGAVKLTPAHDFNDYQLGQRHNL-----EFINILNENGTLNDNA------------------ 458
gi 1711655    414 PRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNL-----EFINILTDDGLLNEECg----------------- 471
gi 239938717  302 NGAFTVLVD-NYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIirkdsLPVCPVDASGCFTTEV------------------ 362
gi 123407059  304 DRESLVING-DHVTTDAGTGCVHTAPGHGEDDYIVGQKYEL-----PVISPIDDKGVFTEEG------------------ 359
gi 12644012   303 GRKSVLIMG-EHVLMDGGSGLVHTAPGHGEDDYYACLKYGI-----EVLMPVDDSGCYDETLrakgll-------pshll 369
gi 2507434    312 GFDVPAILG-DHVTLDAGTGAVHTAPGHGPDDYVIGQKYGL-----ETANPVGPDGTYLPGTy----------------- 368
gi 829189179  328 DGCFRILAG-DFVTADAGTGIVHCAPGFGDDDYKVSVANNIik-pdDPPVPVDENGHFTNVV------------------ 387
gi 135134     303 ETAFRVISD-DYVTSDSGTGIVHNAPAFGEEDNAACLKNGVisedsVLPNAIDDLGRFTKDV------------------ 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        360 GQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISK-------VRQDILDAIE---- 428
gi 251757438  312 LQYQGMDRFECRKKLVKDLQEAGVLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQP-------LADAAIELQKke-e 383
gi 122263839  310 GKYNGMDRFEARKAMVADLDKEGLLLKVEPIVHSVGHSERTGVQVEARLSTQWFVKMKP-------LADAAIKAQQeadk 382
gi 2507438    330 AEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADV-------LAKPAVEAVEn--g 400
gi 1174549    336 ADYRGLERFAARKKIVADFEALGLLDEIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKP-------LADVAIKAVEd--g 406
gi 135184     459 GPFKGQKRFDARYTVVEELTKLGLFVKKEPNPMKIPLCEKSKDVIEPMMTEQWWVRMKE-------MGEAALQVVEe--g 529
gi 1711655    472 PEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSE-------MAKDAIKVVRd--g 542
gi 239938717  363 TDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVEN-------MVDQLLRNND---- 431
gi 123407059  360 GQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISK-------VRQDILDAIE---- 428
gi 12644012   370 EEFIGLHIFKANEKILELLGEK--LLHSSKFIHSYPFCWRTHKPVIYRATKQWFILMDEpklqgktLRECAKEQLL---- 443
gi 2507434    369 PTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQk-----gLRAQSLKEIK---- 439
gi 829189179  388 SDFAGVYIKEADKLIRKNLKERGLLLVDSSFKHNYPFCWRSDTPLIYKAVHCWFIKVTA-------LKDDLLANNK---- 456
gi 135134     364 PDFEGVYVKDADKLIIKYLTNTGNLLLASQIRHSYPFCWRSDTPLLYRSVPAWFVRVKN-------IVPQMLDSVM---- 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        429 NTNFKVNW-GKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAEN-GEIIMtketvn-hvadlFAEHGSNIWfereakdllp 505
gi 251757438  384 KVNFVPDR-FEKTYLHWMENIRDWCISRQLWWGHRIPAWYHKEtGELYVg----------lEAPEDSENW---------- 442
gi 122263839  383 KVTFVPDR-FEHTYLQWMENIHDWVISRQLWWGHQIPAWYNKQtGETYVg----------mEAPKDIENW---------- 441
gi 2507438    401 DIQFVPKQ-YENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEA-GNVYVg----------rNEDEVRKENnlga------ 462
gi 1174549    407 EIQFVPKQ-YENLYFSWMRDIQDWCISRQLWWGHRIPAWYDAEgN-VYVa----------rNEEEVRSKYnlds------ 468
gi 135184     530 KVKISPES-ATKSYKRWLADIQDWCISRQLWWGHRIPAYRVIFeGEEGQreneksewvvgrTQEEAQAKAeakfag---- 604
gi 1711655    543 QITITPKS-SEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIeGEEHDridgdy-wvagrSMEEAEKKAaakypn---- 616
gi 239938717  432 LCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDfEEVVCigsv----aeleELSGAKISDlhresvdhlt 507
gi 123407059  429 NTNFKVNW-GKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENgE-IIMtketvn-hvadlFAEHGSNIWfereakdllp 505
gi 12644012   444 KTTFYPQS-GVKRIGSMVENRPDWCISRQRDWGTPIAFFRDKNtKEVIFddelfd-fvaaiFEKHGADAWwefeikdlip 521
gi 2507434    440 GVQWIPDW-GQARIESMVANRPDWCISRQRTWGVPMSLFVHKDtEELHPrtlelmeevakrVEVDGIQAWwdldakei-- 516
gi 829189179  457 KAYWVPKFaQEGRFNNWLQNVSDWCFSRSRFWGNPIPIWVSEDfEEVVCigsve---elkkLTGATEITDlhkdfidhlt 533
gi 135134     433 KSHWVPNTiKEKRFANWIANARDWNVSRNRYWGTPIPLWVSDDfEEVVCvgsik---eleeLTGVRNITDlhrdvidklt 509
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        506 egfthpgspngtfTKETDIMDVWFDSGSSHRGVL----E-TRPELS--FPADMYLEGSDQYRGWFNSSITTSVATRGVS- 577
gi 251757438  443 -------------EQDTDVLDTWFSSALWPFSTMgwpdV-TAEDFKryYPTDVLVTGYDIIFFWVSRMIFQGIEFTGER- 507
gi 122263839  442 -------------QQDPDVLDTWFSSALWPFSTMgwpdT-DSPDYKryYPTDTLVTGYDIIPFWVARMIFQGLHFTGER- 506
gi 2507438    463 ---------dvvlRQDEDVLDTWFSSALWTFSTLgwpeN--TDALRqfHPTSVMVSGFDIIFFWIARMIMMTMHFIKDEn 531
gi 1174549    469 ---------avelKQDEDVLDTWFSSGLWTFSTLgwpeQ--TKELKmfHPTDVLITGFDIIFFWVARMIMFTMHFVKDEn 537
gi 135184     605 --------rkftlEQDPDCLDTWFSSGLWPMAILgwpnT-ENLDFKkfFPTSMLETGWDILFFWVSRMIMLSLKMTGEV- 674
gi 1711655    617 --------skftlEQDEDVLDTWFSSGLWPFSTLgwpeK--TKDMEtfYPFSMLETGWDILFFWVTRMILLGLKLTGSV- 685
gi 239938717  508 ---ipsrcgkgslHRISEVFDCWFESGSMPYAQVhypfE-NKREFEdaFPADFIAEGIDQTRGWFYTLLVLATALFGQP- 582
gi 123407059  506 egfthpgspngtfTKETDIMDVWFDSGSSHRGVLe-----TRPELS--FPADMYLEGSDQYRGWFNSSITTSVATRGVS- 577
gi 12644012   522 ---tnskykaenlEKVYDILDVWFDSGSTFNAVLnsglY-DAGEKR----ASMYLEGSDQHRGWFQSSLLVGTAINESA- 592
gi 2507434    517 -----lgdeadqyVKVPDTLDVWFDSGSTHSSVVd---V--RPEFAg-HAADMYLEGSDQHRGWFMSSLMISTAMKGKA- 584
gi 829189179  534 ---ipsqkgkgvlRRIDEVFDCWFESGSMPYGQQhypfSmNEEEFSkrFPADFIGEGIDQTRGWFYTLNVISTALRNSN- 609
gi 135134     510 ---ipskqgkgdlKRIEEVFDCWFESGSMPYASQhypfE-NTEKFDerVPANFISEGLDQTRGWFYTLAVLGTHLFGSV- 584
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QU2_A        578 -----PYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVK-------------------------------------QKGA 615
gi 251757438  508 -----PFKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVID-------------------------------------KYGA 545
gi 122263839  507 -----PFKYTLIHGLMRDEQGRKMSKSLGNGIDPMDVIE-------------------------------------KYGA 544
gi 2507438    532 gkpqvPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrtekqfpngiePHGT 611
gi 1174549    538 gkpqvPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDgisledllekrtgnmmqpqlaekiakatrkefaegiaAHGT 617
gi 135184     675 -----PFTEVYCHSLIRDSEGRKMSKSLGNVIDPLDIIRgieledlhakllvgnlkeeevaratkyqktafpggipECGA 749
gi 1711655    686 -----PFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGT 760
gi 239938717  583 -----PFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQ-------------------------------------KYGA 620
gi 123407059  578 -----PYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVK-------------------------------------QKGA 615
gi 12644012   593 -----PYESILTHGFTTDEKGQKMSKSKGNVIASEYVAK-------------------------------------TYGV 630
gi 2507434    585 -----PYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMN-------------------------------------KLGA 622
gi 829189179  610 -----PYKNLIVNGIVLAADGKKMSKSKKNYDDPLLIAS-------------------------------------KYSV 647
gi 135134     585 -----PYKNVIVSGIVLAADGRKMSKSLKNYPDPSIVLN-------------------------------------KYGA 622
                         730       740
                  ....*....|....*....|
1QU2_A        616 DIARLWVS-STDYLADVRIS 634
gi 251757438  546 DSLRYFLAtGSSPGQDLRFS 565
gi 122263839  545 DALRWFLItGNKPGQDTRFS 564
gi 2507438    612 DALRFTLAaLASTGRDINWD 631
gi 1174549    618 DALRFTLAaLASNGRDINWD 637
gi 135184     750 DAMRFTLLsYTTGGGDINFD 769
gi 1711655    761 DAMRFALCaYTTGGRDINLD 780
gi 239938717  621 DALRLYLI-NSPVVRAENLR 639
gi 123407059  616 DIARLWVS-STDYLADVRIS 634
gi 12644012   631 EILRLWIL-LSDYSSDLKIS 649
gi 2507434    623 DILRLWVA-STDYTGEMAVS 641
gi 829189179  648 DAIRLYMI-NSPLVRAEEMS 666
gi 135134     623 DALRLYLI-NSPVLKAESLK 641
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