2QO3,4NA1,5ERF,4JRH,1E5M,4B7V,4JGA,1TQY,2GP6,2WGD


Conserved Protein Domain Family
ketoacyl-synt

?
pfam00109: ketoacyl-synt 
Click on image for an interactive view with Cn3D
Beta-ketoacyl synthase, N-terminal domain
The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.
Statistics
?
PSSM-Id: 333845
View PSSM: pfam00109
Aligned: 90 rows
Threshold Bit Score: 86.9174
Threshold Setting Gi: 81345842
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2QO3_A         7 PIAIVSMACRLPGGVNtPQRLWELLREGGETLS---GFPTDRgWDLARLH---HPDPDNPGTSYVDKGGFlddAAGFDAE 80  Saccharopolyspo...
P39525         4 RVVITGLGCVTPLGRS-LSESWGNLLSSKNGLTpitSLPNYN--EDYKLReksIPSTITVGKIPENFQNE---NSAINKL 77  Saccharomyces c...
P9WQD7        12 yVVVTGIAMTTALATD-AETTWKLLLDRQSGIR---TLDD----PFVEEF---DLPVRIGGHLLE----------EFDHQ 70  Mycobacterium t...
P9WQD9        13 SVVVTAVTATTSISPD-IESTWKGLLAGESGIH---ALED----EFVTKW---DLAVKIGGHLKD----------PVDSH 71  Mycobacterium t...
WP_015037162   4 SVVVTGLGVAAPNGLG-REDFWASTLGGKSGIG---RLT--R-FDPTGY------PARLAGEVPG---------FAAEEH 61  Streptomyces ve...
WP_015660679   7 TVVVTGIGATTPLGGD-AASTWEGLVTGRSGVK---ALEQ-E-WAADQA-------VRIAAPVAV-------------EP 60  Streptomyces da...
CBI27767     107 RVVVTGMGVMSPIGHE-PDSFYNNLLEGVSGIS---EIES---FDCSHF------PTRIAGEIKS---------FSTDGW 164 wine grape
WP_005545121   3 RVVITGIGAVTAFGKT-WQEIKTAFQRKQNAVQa--KAD-----WAERYP---ELEARLGAEIHG---------YQPPSH 62  Aggregatibacter...
2GP6_A        29 yVVVTGIAMTTALATD-AETTWKLLLDRQSGIR---TLDD----PFVEEF---DLPVRIGGHL----------LEEFDHQ 87  Mycobacterium t...
2WGD_A        13 svvvtavtattsISPD-IESTWKGLLAGESGIH---ALED----EFVTKW---DLAVKIGGHLKDPV----------DSH 71  Mycobacterium t...
2QO3_A        81 FFGVSPREAAAMDPQQRLLLETSWELVENAGIDPhs----lrGTA-----TGVFLGVAKF----GY---G----EDTAAA 140 Saccharopolyspo...
P39525        78 LFTSQDER--RTSSFIKLALRTTYEALHNAGLLNpndi-tinTSLcnldhFGCLIGSGIGs---IQd--I----YQTSLQ 145 Saccharomyces c...
P9WQD7        71 LTRIELR---RMGYLQRMSTVLSRRLWENAGSPEv------dTNR-----LMVSIGTGLG----SA---E----ELVFSY 125 Mycobacterium t...
P9WQD9        72 MGRLDMR---RMSYVQRMGKLLGGQLWESAGSPEv------dPDR-----FAVVVGTGLGg---AErivE----SYDLMN 130 Mycobacterium t...
WP_015037162  62 LPSRLLP---QTDRMTRLALVAADWALADAGVRPee----qdDFD-----MGVVTASASGg---FEfgqG----ELQKLW 122 Streptomyces ve...
WP_015660679  61 TEVIPRPQARRLDRSAQFALIAAKEAWADAGFTDra----geDSNvdpdrLGAVIASGIGg--vTTl-lD----QYDVLK 129 Streptomyces da...
CBI27767     165 IAPKLSK---RMDKFMLYMLTAGKKALADGGITEdv----tdELDks--rCGVLIGSAMGgikvFN---D----AIEALR 228 wine grape
WP_005545121  63 WNRKQLR---SLGRVSQFAVEAAERALANADLLDengdilayLKDg---rMGVACGSSTG----STndiK----DAAELL 128 Aggregatibacter...
2GP6_A        88 LTRIELR---RMGYLQRMSTVLSRRLWENAGSPev------dTNR-----LMVSIGTGLG----SA---E----ELVFSY 142 Mycobacterium t...
2WGD_A        72 MGRLDMR---RMSYVQRMGKLLGGQLWESAGSPev------dPDR-----FAVVVGTGLG----GA---EriveSYDLMN 130 Mycobacterium t...
2QO3_A       141 E------DVEGYS--VTG-V-APAVASGRISYTMGLEGPSISVDTACSSS-LVALHLAVESLRKGESSMAVVGGAAVMAT 209 Saccharopolyspo...
P39525       146 Fhn---dNKRINPy-FVP-KiLTNMAAGNVSIKFNLRGLSHSVSTACATGnNSIGDAF-NFIRLGMQDICVAGASETSLH 219 Saccharomyces c...
P9WQD7       126 DdmrargMKAVSPl-TVQ-KyMPNGAAAAVGLERHAKAGVMTPVSACASG-AEAIARAWQQIVLGEADAAICGGVETRIE 202 Mycobacterium t...
P9WQD9       131 ag----gPRKVSPl-AVQ-MiMPNGAAAVIGLQLGARAGVMTPVSACSSGsEAIAHAW-RQIVMGDADVAVCGGVEGPIE 203 Mycobacterium t...
WP_015037162 123 Sq----gSQYVSAy-QSF-AwFYAVNSGQISIRNGMKGPSGVVVSDQAGG-LDAVAQARRQIRKGTR-LIVSGGVDASLC 194 Streptomyces ve...
WP_015660679 130 Ekg----vRRVSPh-TVP-MlMPNGPSANVGLAVGARAGVHTPVSACASG-AEAIGYAIEMIRSGRADVVVAGGTEAAIH 202 Streptomyces da...
CBI27767     229 v-----sYRKMNPf-CVP-FaTTNMGSAMLAMDLGWMGPNYSISTACATSnFCILNAS-NHIIRGEADMMLCGGSDAAII 300 wine grape
WP_005545121 129 Mtg----kSDGFNanTYV-RmMPHTTTANIGIFFGLTGRIIPTSSACSSGsQGIGYAY-ESIKYGLIPMMLAGGAE-EFC 201 Aggregatibacter...
2GP6_A       143 DdmrargMKAVSPl-TVQkY-MPNGAAAAVGLERHAKAGVMTPVSACASG-AEAIARAWQQIVLGEADAAICGGVETRIE 219 Mycobacterium t...
2WGD_A       131 Ag----gPRKVSPl-AVQ-MiMPNGAAAVIGLQLGARAGVMTPVSACSSG-SEAIAHAWRQIVMGDADVAVCGGVEGPIE 203 Mycobacterium t...
2QO3_A       210 PGVFVDFSRQR--ALAA--D----GR---SKAFGAGA---DGFGFSEGVTLVLLERL 252 Saccharopolyspora erythraea
P39525       220 PLSLAGFIRAKs-ITTN-------------GISRPFDtqrSGFVLGEGCGMIVMESL 262 Saccharomyces cerevisiae S288c
P9WQD7       203 AVPIAGFAQMRi-VMST--Nn--dDPagaCRPFDRDR---DGFVFGEG-GALLLIET 250 Mycobacterium tuberculosis H37Rv
P9WQD9       204 ALPIAAFSMMRa-MSTR--Nd---EP---ERASRPFDkdrDGFVFGEA-GALMLIET 250 Mycobacterium tuberculosis H37Rv
WP_015037162 195 PWGWVAQLASDr-LSTS--E----EP---ARAYLPFDreaQGHVPGEG-GAILVMEA 240 Streptomyces venezuelae
WP_015660679 203 PLPIAAFGNMMa-MSKN--Ne---DP---EGASRPYDvarDGFVLGEGAGVVVLESA 250 Streptomyces davawensis
CBI27767     301 PIGLGGFVACRa-LSQR--Nn---DP---TKASRPWDtnrDGFVMGEGAGVLLLEEL 348 wine grape
WP_005545121 202 PSEVYVFDSLY--AASR--Nv--nNP---SKTPRPYDndrDGLVIGEGAGIFVLEEL 249 Aggregatibacter actinomycetemcomitans
2GP6_A       220 AVPIAGFAQMRivMSTN--NddpaGA---CRPFDRDR---DGFVFGEGGALLLIETE 268 Mycobacterium tuberculosis
2WGD_A       204 ALPIAAFSMMR--AMSTrnD----EP---ERASRPFDkdrDGFVFGE-AGALMLIET 250 Mycobacterium tuberculosis H37Rv
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap