2QEP,2C7S,3SR9,3SR9,5AWX,2PBN,2PA5,2JJD,2JJD,2NLK,1P15,2PI7,3CWE,5J8R,2QCJ,1L8K,2B49,2OC3,2I75,4HJP,1YGR,3D42,1WCH,5IBM,2BIJ,2BZL


Conserved Protein Domain Family
Y_phosphatase

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pfam00102: Y_phosphatase 
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Protein-tyrosine phosphatase
Statistics
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PSSM-Id: 333839
View PSSM: pfam00102
Aligned: 119 rows
Threshold Bit Score: 150.452
Threshold Setting Gi: 74964442
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QEP_A      57 NVPKNRSLAVLTYDHSRVLLk------------------------------aENSHShSD--YINASPI----------- 93   human
O01923     808 EQMKQRLPIPLVMD-TRVVL--------------------------------KDYGTlFNddYIHANRV----------- 843  Caenorhabditis e...
Q20252     164 NIDFSQSENVELYDTNRVKG------------------------------------GgEAdfFYHGSTL----------- 196  Caenorhabditis e...
Q18301     158 HSSRNRHNDSKCYDHNRIIV------------------------------------QmCKddYINGSKIn---------- 191  Caenorhabditis e...
O45095     243 NKVRNREGCPKIYDENRVQL---------------------------------NRPGhEDvnYINASVItltdvcrrmac 289  Caenorhabditis e...
O45079     180 NLQMNQADNYPILDSTIVKN------------------------------------PaQPdsYVNMSSVi---------- 213  Caenorhabditis e...
P91147      72 NLPVNVRLPIPIRDNRRVLCg-------------------------------------SDeeFFPGQYV----------- 103  Caenorhabditis e...
Q20402     237 YLTKARSKMVPCAEFSRVKLndglgrlddrnelrngmfsdeheflqeegytaKSTYGtTD--FIHANYV----------- 303  Caenorhabditis e...
Q18385     174 NTFKNQRKDVPCIDDTRVKL-----------------------------------ADpNIvyYIHANHIm---------- 208  Caenorhabditis e...
NP_497642  714 HLYRCSSPRYT-HDWARVRMs-------------------------------SDQPDdCD--FYDACHVfpwqe------ 753  Caenorhabditis e...
2QEP_A      94 --------MDHDpR---NPAYIATQGP-------LP-ATV---ADFWQMVWESG-CVVIVMLTPLAEN---------GV- 140  human
O01923     844 -------------TcshGLQLILSQAPqeangesCE-STI---ESYWWTAKQEK-STQLVMMCDFDEKc-------pGKt 898  Caenorhabditis e...
Q20252     197 --------TIPSvT---TKSTILAQLA-------IV-DSPqslESFWIMVASQK-IQRLFILLGEEEL---------DK- 246  Caenorhabditis e...
Q18301     192 -------------VphfTPSIYLVQLP--------KmDSVdavEEFWRVVFHEQ-CQTVHIIARPEEL---------TN- 239  Caenorhabditis e...
O45095     290 vpayvhlvVLYFvIfqfEHKLIVAQLPqm---enE--SFV---EDFWYMIYQEQ-IHLVYLMVPDDKl---------KN- 350  Caenorhabditis e...
O45079     214 -------------VphcRYPILMAQMP--------KrGFE---EEFWRAAFNESvVIMYVLMGTEDEK------------ 257  Caenorhabditis e...
P91147     104 -----------RmE---GAEYIIVQAP-------TK-KSS---KLIWRVILKDH-IRILVCLCHDEQMs-------gSDd 150  Caenorhabditis e...
Q20402     304 --------KGGP-L---LNTFICAQAP-------LK-NTQ---EDFWRMVFQEK-CQFIVMLNSAVDSstlgpldsaNR- 358  Caenorhabditis e...
Q18385     209 -------------FdhlKKTYITTQHP-------LP-GTL---NDFWAMVADQK-VETIVSLTSSSSAsn---------p 254  Caenorhabditis e...
NP_497642  754 ----vfekVAHK-Y---KNKLICASSP-------MYnVTV---GILWHWLFEND-VKYVVMLNQFLEK---------GL- 804  Caenorhabditis e...
2QEP_A     141 RQCYHYWPd-------EGSNLYHIYEVNLV-------SEHIWCeDFLVRSFYLKNLQTN--------ETRTV-TQFHFL- 196  human
O01923     899 NSCARYYPes-----vGESMKFKNLTVECK--------SKIAEkDFETRELEVKFDGHEp----------HTvTHSRLV- 954  Caenorhabditis e...
Q20252     247 PTLSEYFP--------EDFKEFKTIRVNNRkt----vPKTEEQaNTQLYYEVVPKDCAEa--------------PFAMIe 300  Caenorhabditis e...
Q18301     240 PAIDKLFCqe-----sGAWLYANGFFVNTRk-----vEKKENAkADMFVVELLPEGCSNa----------VMcSVYLHT- 298  Caenorhabditis e...
O45095     351 TTTSLFNDe------nGGYQYTGKMFINNRr-----aDVSGDPkEYTIEVLPEGNSDS------------VIcQVHHHA- 406  Caenorhabditis e...
O45079     258 ---NDFFPtt-----mGAYVYYGAMFVNIRk------VEKMDEeRTRYTIEVLPNGFSNs----------VMmNVYVHT- 312  Caenorhabditis e...
P91147     151 GKCYTYFPtele-qkmEAELMKGTLSIVCKareglsmGATKYElELTDSEVVIDKNSDDpnasnyksH--RL-IVFHMN- 225  Caenorhabditis e...
Q20402     359 NHCPYYWPra-----eNESLRFGSFHITCMk-----vDSKADP-LFTITKLKVQKVGGNll-----dA--EFdEELFLE- 419  Caenorhabditis e...
Q18385     255 NVYPMYYPnk-----pETFNNFGQFFVYCKtv---tqPKTKYGcKEYKFELVVQADNEEr----------RSvRLYHYP- 315  Caenorhabditis e...
NP_497642  805 QASEVWFPlvkgekarFRRNAYREYIVECTdv---kkKYKAAGiQRLVKVTLVHNHQVI--------ETKQM-KILHML- 871  Caenorhabditis e...
2QEP_A     197 ---SWY-DRGVP--SS-----SRSLL----DFRRKVNKCY--------RGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMA 253  human
O01923     955 ---GWN-PLNVQ--PD-----TLLFT----SLIQKIKNST------------TPVMVHCIDGISRSAAFASMIIGYQLVI 1007 Caenorhabditis e...
Q20252     301 icdFWP-DAKIPtmG------YNRIA----ATAASVFESD--------IDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ 361  Caenorhabditis e...
Q18301     299 ---YWK-PLFGP--DR-----FGAQI----RAAHQIAKNE---------NGNSPTVIASVNGSGRNAALLTLAVVEDQLT 354  Caenorhabditis e...
O45095     407 ---PWK-HLQQP--PK-----TLPII----KMIHQFLSEK--------QVQNAGVCVVSLFGCGRACSFIGALYAINQLN 463  Caenorhabditis e...
O45079     313 ---GWE-ASGVPvrYAn---tTRSVV----DVMNFVKTSS----------GTEKMLVVSKNGCGRAGFFLSLGAAFCCLN 371  Caenorhabditis e...
P91147     226 ---TWS-GQKPT--SGnaleqAQNVA----LFFREVKKFEmdilrksmENFVPPVMLQSFDGINRASTGWVALMLLRDVE 295  Caenorhabditis e...
Q20402     420 ---HWQwDWQ-----------YLGDVhwpfRVLRKARQLS------------TPTIVQCIDGCSKSGTLVSIETALMHFI 473  Caenorhabditis e...
Q18385     316 ---HWT-KNMVP--AS-----SKVVL----NLVKKIGKKK----------SQAPVVVQCETGVNQSAELVFVDAMCTLLT 370  Caenorhabditis e...
NP_497642  872 ---EWD-QDCLP--EN-----WQPYV----RICERMNRES----------LHHPVVVMSKHGSGRAMTLILSLMAAVMAR 926  Caenorhabditis e...
2QEP_A     254 KGAKe--IDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE 291  human
O01923    1008 Q--SlgsVKLEAVVSYIRSQRAMAITSALELAFVDAGIVK 1045 Caenorhabditis elegans
Q20252     362 Age---aPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT 398  Caenorhabditis elegans
Q18301     355 Rgk---ePKISEIVRTIREQRPQSVDSYIQYVSLYMATNW 391  Caenorhabditis elegans
O45095     464 NGIE---PNICEIMKNIKQQRPGGVESFAQYASIYAIVFD 500  Caenorhabditis elegans
O45079     372 Dns---ePRIGEIVKAIRSQRPNAVDSIKQYASIYLCFVY 408  Caenorhabditis elegans
P91147     296 KREC---FDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN 332  Caenorhabditis elegans
Q20402     474 RGSPitkSLILQSCVFVRLQRRLSVSSVLLYLFIYRVILR 513  Caenorhabditis elegans
Q18385     371 Rqv---eVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMK 407  Caenorhabditis elegans
NP_497642  927 LDDD---LSIHSMCQSGRASKRQSITCCNQVYFWRMVHYE 963  Caenorhabditis elegans
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