Conserved Protein Domain Family

pfam00097: zf-C3HC4 
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Zinc finger, C3HC4 type (RING finger)
The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.
Aligned: 41 rows
Threshold Bit Score: 35.4121
Threshold Setting Gi: 239938588
Created: 18-Apr-2019
Updated: 18-Jul-2019
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2CKL_B         57 CPICLDMLKNTMt-------TKECLHR-FCADCIITALR--------SGNKe--CPTC 96   house mouse
P34537        785 CPSCKTRPKDc--------iMLKCYHL-FCETCIKTMYD--------TRQRk--CPKC 823  Caenorhabditis elegans
P32511        207 CHICSCTFTDIQnynsnfvtSTECNHA-VCFKCYVSIVFg-------KESYk--CSIC 254  Orgyia pseudotsugata multiple nucle...
P40629        148 CIICLTNQVQIL--------TIPCGHLiMCNPCSLNLNNsvctrgvnSNYEk--CPKC 195  Invertebrate iridescent virus 6
P32849        914 CSICTTEPMDLDka-----lFTECGHS-FCEKCLFEYIEfq-----nSKNLglkCPNC 960  Saccharomyces cerevisiae S288C
P36607        877 CPICCNEPIQNPl-------LLNCKHA-CCGDCLSEHIQyqk---rrNIIPp-lCHTC 922  Schizosaccharomyces pombe 972h-
EGA61467       18 CIICCDKKDTETf-------ALECGHE-YCINCYRHYIKdkl---heGNIIt--CMDC 62   Saccharomyces cerevisiae FostersO
AJU44904      206 CPICFEPPETAL--------MTLCGHV-FCCPCLFQMVNss----rtCRQFg-hCALC 249  Saccharomyces cerevisiae YJM1248
XP_015192856  365 CKICAENDKDVK--------IEPCGHL-MCTSCLTSWQE--------SEGQg--CPFC 403  spotted gar
P32512         39 CAVCLETYCVQSnniidflmPSECTHL-FCYKCVLNMYKnam--nvpRAAVs--CPMC 91   Orgyia pseudotsugata multiple nucle...
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