Conserved Protein Domain Family

pfam00097: zf-C3HC4 
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Zinc finger, C3HC4 type (RING finger)
The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.
PSSM-Id: 333836
View PSSM: pfam00097
Aligned: 40 rows
Threshold Bit Score: 35.4121
Threshold Setting Gi: 239938588
Created: 13-Mar-2017
Updated: 23-May-2017
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2CKL_B     57 CPICLDMLKNTMt-------TKECLHR-FCADCIITALR--------SGNKe--CPTC 96   house mouse
Q06438    243 CALCGEWPTMPH--------TIGCEHV-FCYYCVKSSFLf-------DMYFt--CPKC 282  Chinese hamster
P34537    785 CPSCKTRPKDc--------iMLKCYHL-FCETCIKTMYD--------TRQRk--CPKC 823  Caenorhabditis elegans
P32511    207 CHICSCTFTDIQnynsnfvtSTECNHA-VCFKCYVSIVFg-------KESYk--CSIC 254  Orgyia pseudotsugata multiple nucleopol...
P23801     86 CSVCLETYSQQSndtcpfliPTTCDHG-FCFKCVINLQSnam--nipHSTVc--CPLC 138  Autographa californica nucleopolyhedrov...
P40629    148 CIICLTNQVQIL--------TIPCGHLiMCNPCSLNLNNsvctrgvnSNYEk--CPKC 195  Invertebrate iridescent virus 6
P32849    914 CSICTTEPMDLDka-----lFTECGHS-FCEKCLFEYIEfq-----nSKNLglkCPNC 960  Saccharomyces cerevisiae S288c
P36607    877 CPICCNEPIQNPl-------LLNCKHA-CCGDCLSEHIQyqk---rrNIIPp-lCHTC 922  Schizosaccharomyces pombe 972h-
EGA61467   18 CIICCDKKDTETf-------ALECGHE-YCINCYRHYIKdkl---heGNIIt--CMDC 62   Saccharomyces cerevisiae FostersO
AJU44904  206 CPICFEPPETAL--------MTLCGHV-FCCPCLFQMVNss----rtCRQFg-hCALC 249  Saccharomyces cerevisiae YJM1248
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