Conserved Protein Domain Family
zf-C2H2

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pfam00096: zf-C2H2 
Zinc finger, C2H2 type
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.
Statistics
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PSSM-Id: 333835
View PSSM: pfam00096
Aligned: 159 rows
Threshold Bit Score: 28.0368
Threshold Setting Gi: 141644
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q91690  283 FVCHwqDCSrelRPFKAQYMLVVHMRR-H 310  African clawed frog
P07664  223 HICP--ICG---VIRRDEEYLELHMNL-H 245  fruit fly
P07664  405 GFCL--ICN---TNFENKKELEHHLQFdH 428  fruit fly
P24349  233 SSCH--LCH---LPV-PNKFLEAHGNV-H 254  Caenorhabditis elegans
P07664  308 IICS--ICN---VSFKSRKTFNHHTLI-H 330  fruit fly
P20385   74 HYCP--MCH---QQFERPQHVADHMQLcH 97   fruit fly
P08970  523 FPCE--QCD---EKFKTEKQLERHVKT-H 545  fruit fly
P08970  319 FPCS--ICN---ANLRSEALLALHEEQ-H 341  fruit fly
P18739    1 FSCS--QCD---ESFVQRSELELHRQL-H 23   African clawed frog
P23607  542 FKCD--ICL---LTFSDTKEVQQHALV-H 564  house mouse
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