1P1T,3MD1,3MD3


Conserved Protein Domain Family
RRM_1

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pfam00076: RRM_1 
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RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C-terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.
Statistics
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PSSM-Id: 333819
View PSSM: pfam00076
Aligned: 73 rows
Threshold Bit Score: 42.1983
Threshold Setting Gi: 17380398
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1P1T_A        11 VFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDre-tgKPKGYGFCEYQDQETALSAMRNLNG-REFSGRALR 81
gi 119264    250 LYVSGLPKTMTQQELEAIFAPFGAIITSRILQNagndtQTKGVGFIRFDKREEATRAIIALNG-TTPSSCTDP 321
gi 135080    213 LYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDkl-tgRPRGVAFVRYNKREEAQEAISALNNvIPEGGSQPL 284
gi 206729905 216 VYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD-------KGYSFVRFNSHESAAHAIVSVNG-TTIEGHVVK 280
gi 206729905   9 LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDt---aGNDPYCFVEFHEHRHAAAALAAMNG-RKIMGKEVK 77
gi 135080    127 LIVNYLPQDMTDRELYALFRAIGPINTCRIMRDyk-tgYSFGYAFVDFTSEMDSQRAIKVLNG-ITVRNKRLK 197
gi 223590202  48 LIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDki-tgQSLGYGFVNYIDPKDAEKAINTLNG-LRLQTKTIK 118
gi 76803808   92 VFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDek--gNSKGYGFVHFETEEAANTSIDKVNG-MLLNGKKVY 161
gi 76803808  185 VYVKNFTEDFDDEKLKEFFEPYGKITSYKVMSKed--gKSKGFGFVAFETTEAAEAAVQALNGkDMGEGKSLY 255
gi 417689    200 IVIKFQGPALTEEEIYSLFRRYGTI--IDIFPpt---aANNNVAKVRYRSFRGAISAKNCVSG-IEIHNTVLH 266
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