2WWP,1YUP,3ZQ3,3KFF,4ES7,1EW3,1EXS,4RUN,1GM6,3SAO,2K23,4R0B,3L4R,2R73,1DZJ,2HZQ,1BJ7,3FIQ,2HLV,3OJY,1E5P,3NR3


Conserved Protein Domain Family
Lipocalin

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pfam00061: Lipocalin 
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Lipocalin / cytosolic fatty-acid binding protein family
Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.
Statistics
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PSSM-Id: 333807
View PSSM: pfam00061
Aligned: 176 rows
Threshold Bit Score: 30.0852
Threshold Setting Gi: 1708459
Created: 14-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WWP_A       19 LGRWFSAGLASnsswlREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRsphWGSTYSVS 98
gi 27923795  29 EGTYFVKAIVTdseffEKNKPK-ALSPLTVTHLSNGDLEAKFTTNMNGICEEIKMKFEKTDKPGIFST----NDGSRQVL 103
gi 3122324   30 EGTYYVQVIAVdkefpEEEIPR-DMSPLTIMYLDDGKMEARFTMKKDDNCEEINIMLEKTADPRKITMN---RRLRYTCA 105
gi 20141968  32 SGKWFLKALVSeddipIN-----KVSPMLILVLNNGDIELSITHMIYDQCLEVTTILEKTDVPGQYLA----FEGKTHLQ 102
gi 1718160   33 LGRWYLKAMTSdpeipGKKPE--SVTPLILKALEGGDLEAQITFLIDGQCQDVTLVLKKTNQPFTFTA----YDGKRVVY 106
gi 401346    32 SGTWYLKAMTVdrefpEMNLE--SVTPMTLTTLEGGNLEAKVTMLISGRCQEVKAVLEKTDEPGKYTA----DGGKHVAY 105
gi 137823    31 SGTWYLKAAAWdkeipDKKFGSVSVTPMKIKTLEGGNLQVKFTVLIAGRCKEMSTVLEKTDEPAKYTA----YSGKQVLY 106
gi 3121745   32 SGKWYLKAMTAdqevpEKPD---SVTPMILKAQKGGNLEAKITMLTNGQCQNITVVLHKTSEPGKYTA----YEGQRVVF 104
gi 3123036   33 SGVWFIKATVSqrrevEGETL--VAFPIKFTCPEEGTLELRHTLASKGECINVGIRLQRTEEPGQYSA----FWGHTLFY 106
gi 62286940  31 SGIWYAKAMVHngtlpSHKIPS-IVFPVRIIALEEGDLETTVVFWNNGHCREFKFVMKKTEEPGKYTA----FHNTKVIH 105
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
2WWP_A       99 VVETDYDQYALLYSQGSKGpGeDFRMATLYSRTQTPRAELkekFTAFCKAQGFTEDTIVFLPQTD 163
gi 27923795 104 IEKTSVRDHWILFCEGELHg-mQVRIAKLLGPHTDENPKAfqeFKKFVSLKRFNEEKINIPRQTE 167
gi 3122324  106 AVRTSKQKHWILVCPREFQgE-TIRMAKLVGPNTDKNPKAledFYRFIYRERFDKRRIITPKQTE 169
gi 20141968 103 VQLSSVKGHYMLYCDGEIEg-mRFLMTQLIGRDPQENLEAleeFKVFTQIKGLVAENLVILEQME 166
gi 1718160  107 ILPSKVKDHYILYCEGELDg-qEVRMAKLVGRDPENNPEAleeFKEVARAKGLNPD-IVRPQQSE 169
gi 401346   106 IIRSHVKDHYIFYCEGELHg-kPVRGVKLVGRDPKNNLEAledFEKAAGARGLSTESILIPRQSE 169
gi 137823   107 IIPSSVEDHYIFYYEGKIHr-hHFQIAKLVGRDPEINQEAledFQSVVRAGGLNPDNIFIPKQSE 170
gi 3121745  105 IQPSPVRDHYILYCEGELHg-rQIRMAKLLGRDPEQSQEAledFREFSRAKGLNQE-ILELAQSE 167
gi 3123036  107 IYDLPVKDHYIIYCESHPFq-kISQFGYLIGKYPEENQDTlevFKEFIQHKGFLQEKIGVPEQRD 170
gi 62286940 106 VEKTSVNEHYIFYCEGRHNgTsSFGMGKLMGRDSGENPEAmeeFKNFIKRMNLRLENMFVPEIGD 170
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