3GTU,3I69,1AXD,5DQS,1F3A,1GUK,1GSU,4KGI,1VF1,1U3I,1NHY,2PMT


Conserved Protein Domain Family
GST_C

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pfam00043: GST_C 
Click on image for an interactive view with Cn3D
Glutathione S-transferase, C-terminal domain
GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.
Statistics
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PSSM-Id: 333792
View PSSM: pfam00043
Aligned: 46 rows
Threshold Bit Score: 56.1267
Threshold Setting Gi: 27923973
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3GTU_B   107 VMDFRTQLIRLCYSSDHe------------KLKPQYLEELPGQLKQFSMFLGKFS----WFAGEKLTFVDF--LTYDILD 168 human
P40582   114 LQPPLMIEFILSKVKDSgmpfpisylarkvADKISQAYSSGEVKNQFDFVEGEISknngYLVDGKLSGADI--LMSFPLQ 191 Saccharomyces cerev...
P29547   107 LCIQIANTIVPLKGGAPy------------NKK-SVDSAMDAVDKIVDIFENRLKny-tYLATENISLADL--VAASIFT 170 Saccharomyces cerev...
P36008   104 VMSNIARPFLSFKGLIPy------------NKK-DVDACFVKIDNLAAVFDARLRdy-tFVATENISLGDL--HAAGSWA 167 Saccharomyces cerev...
P04907   107 FHPNASPLVFQLLVRPLlg---------gaPDAAVVEKHAEQLAKVLDVYEAHLArn-kYLAGDEFTLADAnhALLPALT 176 Zea mays
P12653   110 LNPILFQVLISPMLGGt-------------TDQKVVDENLEKLKKVLEVYEARLTkc-kYLAGDFLSLADL--NHVSVTL 173 Zea mays
P30110   111 YYPAISPVVFECIIIPFiipg-----ggaaPNQTVVDESLERLRGVLGIYEARLEks-rYLAGDSITFADL--NHIPFTF 182 bread wheat
1AXD_A   109 LNPILFQVLISPMLGGt-------------TDQKVVDENLEKLKKVLEVYEARLTkc-kYLAGDFLSLADL--NHVSVTL 172 Zea mays
AAI54939  82 IVPPASAWVFPTLGIMQy------------NKQAT-EQAKEEIKAVLGVLDSHLKtr-tFLVGERVTLADI--AVTCSLL 145 western clawed frog
1NHY_A   107 LCIQIANTIVPLKGGAPy------------NKKS-VDSAXDAVDKIVDIFENRLKny-tYLATENISLADL--VAASIFT 170 baker's yeast
3GTU_B   169 QNRIFDPKCl--DEFPNLKAFMCRFEALE 195 human
P40582   192 MAFERKFAAp--EDYPAISKWLKTITSEE 218 Saccharomyces cerevisiae S288c
P29547   171 RYFESLFGTewrAQHPAIVRWFNTVRASP 199 Saccharomyces cerevisiae S288c
P36008   168 FGLATILGPewrAKHPHLMRWFNTVAASP 196 Saccharomyces cerevisiae S288c
P04907   177 SARPPRPGCv--AARPHVKAWWEAIAARP 203 Zea mays
P12653   174 CLFATPYASv-lDAYPHVKAWWSGLMERP 201 Zea mays
P30110   183 YFMTTPYAKv-fDDYPKVKAWWEMLMARP 210 bread wheat
1AXD_A   173 CLFATPYASv-lDAYPHVKAWWSGLMERP 200 Zea mays
AAI54939 146 WLYKQVLEPsfrQPFGNVTRWFVTCVNQP 174 western clawed frog
1NHY_A   171 RYFESLFGTewrAQHPAIVRWFNTVRASP 199 baker's yeast
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