2AAO,1S6I,1JBA,2GGZ,2NA0,2I94,1FPW,2L2E,4DS7,2LMT,1GGZ,2AAO,1S6I,2DOQ,3OX6,2LMT,2ROB,1GGZ,4DS7,2BEC,2E30,4IL1,5JOL,2NA0,2GGZ,1JBA,4OV2,2L2E,1FPW,2JPT,1CFP,2BEC,2E30,1JBA,2GGZ,2NA0,2I94,2L2E,1FPW,5JJG,5JJG,1S6I,2AAO,2DOQ,2AAO,1S6I,5JOL,2KYC,4DS7,1NCZ,2LMT,2LMT,4DS7,2DOQ


Conserved Protein Domain Family
EF-hand_1

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pfam00036: EF-hand_1 
Click on image for an interactive view with Cn3D
EF hand
The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.
Statistics
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Aligned: 566 rows
Threshold Bit Score: 26.5803
Threshold Setting Gi: 134759
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AAO_B    64 EILDLXQAADVDNSGTIDYKEFIAATLH 91  thale cress
Q93640   272 IIERIIEEADLDGDSSINFAEFEHVVSR 299 Caenorhabditis elegans
Q99828   152 LIDNILEESDIDRDGTINLSEFQHVISR 179 human
4IL1_C   289 IVDKTIINADKDGDGRISFEEFCAVVGG 316 Norway rat
P28470   132 LVDKSILVLDKDGDGRISFEEFRDVVRT 159 Norway rat
O81223   156 MVDKAFVQADRKNDGKIDIDEWKDFVSL 183 thale cress
Q7FZF1   151 IVSKTFEEADWKKDGIIDLEEWENFVAT 178 thale cress
Q9C5P6   161 IIDKTFEEADTKLDGKIDKEEWRSLVLR 188 thale cress
EDW38628  61 lWDEISAIADDDKDGKISNQEFKDAVKK 88  Drosophila persimilis
A0DAT1   455 lWTEILQMCDANGDGQISQQEFIDFLVK 482 Paramecium tetraurelia
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