2LRS


Conserved Protein Domain Family
dsrm

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pfam00035: dsrm 
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Double-stranded RNA binding motif
Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.
Statistics
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Aligned: 81 rows
Threshold Bit Score: 33.0235
Threshold Setting Gi: 82233708
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2LRS_A      1 NDiCLRKNW------PMPSYRCVKEGGPAHAkrfTFGVRVNT-------SDRGWtdecIGEP-------MpSV-KKAKDS 59   thale cress
Q9LTQ0    319 NE-ICLKKK------WPKPIYSVEEDRSSVQg-kRFVCSAKIki---teEKTLYm---KGDE-------Q-SKiKKAESS 376  thale cress
Q5UQT7    182 LR-YFHQMKwg---hPKYIEEIVIDPKNNQRn-kFISKVKNP-------FDKVIg---IGSA-------S-TK-KKSEQL 237  Acanthamoeba poly...
Q5UQT7    474 LQ-LYNKNK------WGHPVYKILKEEGPDHc-kIFTMGLYL-------GNKLMg---IGKA-------S-SK-KKAEQI 526  Acanthamoeba poly...
Q869Z1    537 EQ-YCKQFG------YPENNVYRSHETSRGSl-mKFSKTFVV-------EMYLPi---QGVVqkititeSdNK-KLSENL 597  Dictyostelium dis...
Q22307    177 NE-FLQKMRlpqvnyGTKIRESNTVKTMETTa-qIFVPQI---------NKNLVg---KGTG-------S-NK-KVSEAA 233  Caenorhabditis el...
O01326    990 QQ-WCLAMRdpsssePDMPEYRVLGIEGPTNn-rIFKIAVYY-------KGKRLa---SAAE-------S-NV-HKAELR 1048 Caenorhabditis el...
Q581T1   1030 QR-YCNVAN------VNYPTFWKSRTVGPISc-rVCLTTIEV-------PGHEYl---RASGv------AwNK-EASQRQ 1084 Trypanosoma brucei
Q86L44      7 QT-YIQQKR------IGYLPVYHSECRGPDHe-rEYRTHIRVgeinskhNNKIVy---SDWY-------K-NK-KTAESC 66   Dictyostelium dis...
BAO93839   21 QQ-CCLTLRteg-kePDIPLYKTLQTVGPSHa-rTYTVAVYF-------KGERIg---CGKG-------P-SI-QQAEMG 78   water buffalo
2LRS_A     60 AAVLLLELL 68   thale cress
Q9LTQ0    377 SAYHMIRAL 385  thale cress
Q5UQT7    238 ASQMALTNL 246  Acanthamoeba polyphaga mimivirus
Q5UQT7    527 ASKKMYQNY 535  Acanthamoeba polyphaga mimivirus
Q869Z1    598 AAVDACEYL 606  Dictyostelium discoideum
Q22307    234 CAMNIVRQM 242  Caenorhabditis elegans
O01326   1049 VAELALANL 1057 Caenorhabditis elegans
Q581T1   1085 AAMHALALL 1093 Trypanosoma brucei
Q86L44     67 CAIKVLNYL 75   Dictyostelium discoideum
BAO93839   79 AAMDALEKy 87   water buffalo
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