1PSO,3CMS,1TZS,2X0B,1HTR,4YBF,3FV3,1UH7


Conserved Protein Domain Family
Asp

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pfam00026: Asp 
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Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Statistics
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Aligned: 32 rows
Threshold Bit Score: 266.828
Threshold Setting Gi: 20141716
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1PSO_E    13 EYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVY----------------------CS--SLA-----CTNHNRFNPEDSST 63  human
P17946    84 EYLTPVTVGKS--TLHLDFDTGSADLWVFSDE----------------------LP--SSE-----QTGHDLYTPSSSAT 132 Aspergillus awamori
P32834    75 GYFANLTLGSNERVYSLTLDTGSPYTWVTAKNitalsaseiwsdtdgvdagrstSDirTNA-----CTNYTCFDYSSTTA 149 Schizosaccharomyces...
P22929    74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVPGQG----------------------T-----------SSLYGTYDHTKSTS 120 Saccharomycopsis fi...
Q00663    73 SYAADIVVGSNQQKQTVVIDTGSSDLWVVDTDa--------------------eCQvtYSGqtnnfCKQEGTFDPSSSSS 132 Candida tropicalis
P0CS83    69 TYAADITVGSNNQKLNVIVDTGSSDLWVPDVNv--------------------dCQvtYSDqtadfCKQKGTYDPSGSSA 128 Candida albicans
P32951    75 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNa--------------------qCGk-GVD-----CKSSGTFTPSSSSS 128 Candida parapsilosis
P32950    74 SYGIRVSVGSNKQEQQVVLDTGSSDFWVVDSSa--------------------sCQkgN-------CKQYGTFDPHSSTS 126 Candida parapsilosis
3FV3_A    13 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNa--------------------qCGk-GVD-----CKSSGTFTPSSSSS 66  Candida parapsilosis
EDN61477  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMDSSnpfclpnsntssysnatyngeeVKp-SID-----CRSMSTYNEHRSST 117 Saccharomyces cerev...
1PSO_E    64 YQ-STSETV-SIT-YGTG-S-MTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLA----YPSISSSG-- 132 human
P17946   133 K--LSGYTW-DIS-YGDGsS-ASGDVYRDTVTVGGVTTNKQAVEAASKISSEFVQNTANDGLLGLA----FSSINTVQpk 203 Aspergillus awamori
P32834   150 RR-TNSSTIgFLAsYGDNtT-VLGYNMVDNAYFAGLTLPGFEFGLATREYDSSQISV-TPGIIGLSvamtITGISSDDkv 226 Schizosaccharomyces...
P22929   121 YK-KDRSGF-SIS-YGDGsS-ARGDWAQETVSIGGASITGLEFGDATSQDV-------GQGLLGIG----LKGNEASAqs 185 Saccharomycopsis fi...
Q00663   133 AQ-NLNQDF-SIE-YGDLtS-SQGSFYKDTVGFGGISIKNQQFADVTTTSV-------DQGIMGIG----FTAVEA---- 193 Candida tropicalis
P0CS83   129 SQ-DLNTPF-KIG-YGDGsS-SQGTLYKDTVGFGGVSIKNQVLADVDSTSI-------DQGILGVG----YKTNEAGG-- 191 Candida albicans
P32951   129 YK-NLGAAF-TIR-YGDGsT-SQGTWGKDTVTINGVSITGQQIADVTQTSV-------DQGILGIG----YTSNEAVYdt 193 Candida parapsilosis
P32950   127 FK-SLGSSFrSIG-YGDKsS-SIGTWGQDTIYLGGTSITNQRFADVTSTSV-------NQGILGVG------RVETES-- 188 Candida parapsilosis
3FV3_A    67 YK-NLGAAF-TIR-YGDG-StSQGTWGKDTVTINGVSITGQQIADVTQTSV-------DQGILGIG----YTSNEAVYdt 131 Candida parapsilosis
EDN61477 118 YQyLENGRF-YIT-YADGtF-ADGSWGTETVSINGIDIPNIQFGVAKYATTP------VSGVLGIG----FPRRESVKgy 184 Saccharomyces cerev...
1PSO_E   133 ----ATPV--FDN----IWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTV--------EGY--WQI 192 human
P17946   204 ---aQTTF--FDT----VKSQ--LDSPLFAVQL--KHDAPGVYDFGYIDDSKYTGSITYTDADSs-------QGY--WGF 261 Aspergillus awamori
P32834   227 --vaFTPPtiVDQ----LVSANVIDTPAFGIYLN---EDVGELIFGGYDKAKINGSVHWVNISSsd-----dSTF--YSV 290 Schizosaccharomyces...
P22929   186 ---sNSFT--YDNlplkLKDQGLIDKAAYSLYLNSEDATSGSILFGGSDSSKYSGSLATLDLVNiddegdstSGAvaFFV 260 Saccharomycopsis fi...
Q00663   194 ----GYNL--YSNvpvtLKKQGIINKNAYSCDLNSEDASTGKIIFGGVDNAKYTGTLTALPVTS--------SVE--LRV 257 Candida tropicalis
P0CS83   192 ----S-----YDNvpvtLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTS--------DRE--LRI 252 Candida albicans
P32951   194 sgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTS--------SQP--LTI 261 Candida parapsilosis
P32950   189 ----ANPP--YDNvpitLKKQGKIKTNAYSLYLNSPGAATGTIIFGGVDNAKYSGKLIEEPLVS--------DRY--LAV 252 Candida parapsilosis
3FV3_A   132 sgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTS--------SQA--LTI 199 Candida parapsilosis
EDN61477 185 ---eGAPNeyYPNfpqiLKSEKIIDVVAYSLFLNSPDSGTGSIVFGAIDESKFSGDLFTFPMVNeyptivdaPAT--LAM 259 Saccharomyces cerev...
1PSO_E   193 TVDSITMNGEAI-----ACAEGCQAI-------VDTGTSLLTGPTSPIANIQSDIGASENSDgd----mvVSCSA-ISSL 255 human
P17946   262 STDGYSIGDGSS------SSSGFSAI-------ADTGTTLILLDDEIVSAYYEQVSGASGETeag--gyvFSCST---NP 323 Aspergillus awamori
P32834   291 NLESITVTNSTSsnnvqSSKRSSKDIevnttvtLDTGTVYIYLPEDTVESIADQYQGIVSEYgy----vvIYCDS-FSDS 365 Schizosaccharomyces...
P22929   261 ELEGIEAGSSSI------TKTTYPAL-------LDSGTTLIYAPSSIASSIGREYGTYSYSYgg----yvTSCDA---TG 320 Saccharomycopsis fi...
Q00663   258 HLGSINFDGTSV-------STNADVV-------LDSGTTITYFSQSTADKFARIVGA--TWDsrneiyrlPSCD--LSGD 319 Candida tropicalis
P0CS83   253 SLGSVEVSGKTI------NTDNVDVL-------LDSGTTITYLQQDLADQIIKAFNGKLTQDsngnsfyeVDCN--LSGD 317 Candida albicans
P32951   262 SLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDCNTdTSGT 327 Candida parapsilosis
P32950   253 NLKSLNYNGDNS-------NAGFGVV-------VDSGTTISYLPDSIVNDLANKVGAYLEPVglgnelyfIDCNAnPQGS 318 Candida parapsilosis
3FV3_A   200 SLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDCNTdTSGT 265 Candida parapsilosis
EDN61477 260 TIQGLGAQNKSScehetFTTTKYPVL-------LDSGTSLLNAPKVIADKMASFVNASYSEEegi---yiLDCPV-SVGD 328 Saccharomyces cerev...
1PSO_E   256 PDIVFTI-NGVQYPVPPSAYI--LQs-----eGSCISGF-QgmnlPTESGELWILGDVFIRQYF-TVFDRANNQVGLAPV 325 human
P17946   324 PDFTVVI-GDYKAVVPGKYIN--YApis-tgsSTCFGGI-Q----SNSGLGLSILGDVFLKSQY-VVFNSEGPKLGFAAQ 393 Aspergillus awamori
P32834   366 DYISFNFgSDADFHVSVNDLV--IYrqestsgDICYLAL------FEGDTSSYLLGQYFLQYVY-SIYDWDAQKIGLAAL 436 Schizosaccharomyces...
P22929   321 PDFKFSF-NGKTITVPFSNLL--FQnse--gdSECLVGV------LSSGSNYYILGDAFLRSAY-VYYDIDNSQVGIAQA 388 Saccharomycopsis fi...
Q00663   320 AVVNFD--QGVKITVPLSELI--LKds---dsSICYFGI--------SRNDANILGDNFLRRAY-IVYDLDDKTISLAQV 383 Candida tropicalis
P0CS83   318 VVFNFS--KNAKISVPASEFAasLQgddgqpyDKCQLLF--------DVNDANILGDNFLRSAY-IVYDLDDNEISLAQV 386 Candida albicans
P32951   328 TVFNFG--NGAKITVPNTEYV--YQng----dGTCLWGI--------QPSDDTILGDNFLRHAYyLLYNLDANTISIAQV 391 Candida parapsilosis
P32950   319 ASFTFD--NGAKITVPLSEFV--LQst----aNACVWGLqS----SDRQNVPPILGDNFLRHAYaFQLDKETVLSRSGEV 386 Candida parapsilosis
3FV3_A   266 TVFNFG--NGAKITVPNTEYV--YQng----dGTCLWGI-Q----PSDDT---ILGDNFLRHAY-LLYNLDANTISIAQV 328 Candida parapsilosis
EDN61477 329 VEYNFDF-GDLQISVPLSSLI--LSpet--egSYCGFAV-------QPTNDSMVLGDVFLSSAY-VVFDLDNYKISLAQA 395 Saccharomyces cerev...
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