1PSO,3CMS,1TZS,2X0B,1HTR,4YBF,3FV3,1UH7,1J71,1IBQ,5HCT


Conserved Protein Domain Family
Asp

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pfam00026: Asp 
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Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Statistics
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PSSM-Id: 333777
View PSSM: pfam00026
Aligned: 35 rows
Threshold Bit Score: 264.901
Threshold Setting Gi: 20141716
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1PSO_E    13 EYFGTIGIGTPAQDFTVVFDTGSSNLWVPSV--Y----------------------CS-------SLA-----CTNHNRF 56  human
P32834    75 GYFANLTLGSNERVYSLTLDTGSPYTWVTAK--NitalsaseiwsdtdgvdagrstSDi-----rTNA-----CTNYTCF 142 Schizosaccharomyces...
P22929    74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVPGQ--G----------------------T----------------SSLYGTY 113 Saccharomycopsis fi...
Q00663    73 SYAADIVVGSNQQKQTVVIDTGSSDLWVVDT--Da--------------------eCQv-----tYSGqtnnfCKQEGTF 125 Candida tropicalis
P0CS83    69 TYAADITVGSNNQKLNVIVDTGSSDLWVPDV--Nv--------------------dCQv-----tYSDqtadfCKQKGTY 121 Candida albicans
P32951    75 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDS--Na--------------------qCGk------GVD-----CKSSGTF 121 Candida parapsilosis
P32950    74 SYGIRVSVGSNKQEQQVVLDTGSSDFWVVDS--Sa--------------------sCQk-----gN-------CKQYGTF 119 Candida parapsilosis
EDN61477  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMDS--SnpfclpnsntssysnatyngeeVKp------SID-----CRSMSTY 110 Saccharomyces cerev...
3FV3_A    13 SYASKVSVGSNKQQQTVIIDTGSSDFWVVDS--Na--------------------qCGk------GVD-----CKSSGTF 59  Candida parapsilosis
1J71_A    13 SYAADIVVGSNQQKQTVVIDTGSSDLWVVDTdaE----------------------CQvtysgqtNNF-----CKQEGTF 65  Candida tropicalis
1PSO_E    57 NPEDSSTYQ-STSETV-SIT-YGTG-S-MTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYApFDGILGLA----YPS 127 human
P32834   143 DYSSTTARR-TNSSTIgFLAsYGDNtT-VLGYNMVDNAYFAGLTLPGFEFGLATREYDSSQISV-TPGIIGLSvamtITG 219 Schizosaccharomyces...
P22929   114 DHTKSTSYK-KDRSGF-SIS-YGDGsS-ARGDWAQETVSIGGASITGLEFGDATSQDV-------GQGLLGIG----LKG 178 Saccharomycopsis fi...
Q00663   126 DPSSSSSAQ-NLNQDF-SIE-YGDLtS-SQGSFYKDTVGFGGISIKNQQFADVTTTSV-------DQGIMGIG----FTA 190 Candida tropicalis
P0CS83   122 DPSGSSASQ-DLNTPF-KIG-YGDGsS-SQGTLYKDTVGFGGVSIKNQVLADVDSTSI-------DQGILGVG----YKT 186 Candida albicans
P32951   122 TPSSSSSYK-NLGAAF-TIR-YGDGsT-SQGTWGKDTVTINGVSITGQQIADVTQTSV-------DQGILGIG----YTS 186 Candida parapsilosis
P32950   120 DPHSSTSFK-SLGSSFrSIG-YGDKsS-SIGTWGQDTIYLGGTSITNQRFADVTSTSV-------NQGILGVG------R 183 Candida parapsilosis
EDN61477 111 NEHRSSTYQyLENGRF-YIT-YADGtF-ADGSWGTETVSINGIDIPNIQFGVAKYATTP------VSGVLGIG----FPR 177 Saccharomyces cerev...
3FV3_A    60 TPSSSSSYK-NLGAAF-TIR-YGDG-StSQGTWGKDTVTINGVSITGQQIADVTQTSV-------DQGILGIG----YTS 124 Candida parapsilosis
1J71_A    66 DPSSSSSAQ-NLNQDF-SIE-YGDLtS-SQGSFYKDTVGFGGISIKNQQFADVTTTSV-------DQGIMGIG----FTA 130 Candida tropicalis
1PSO_E   128 ISSSG------ATPV--FDN----IWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTV--------E 187 human
P32834   220 ISSDDkv--vaFTPPtiVDQ----LVSANVIDTPAFGIYLN---EDVGELIFGGYDKAKINGSVHWVNISSsd-----dS 285 Schizosaccharomyces...
P22929   179 NEASAqs---sNSFT--YDNlplkLKDQGLIDKAAYSLYLNSEDATSGSILFGGSDSSKYSGSLATLDLVNiddegdstS 253 Saccharomycopsis fi...
Q00663   191 VEA--------GYNL--YSNvpvtLKKQGIINKNAYSCDLNSEDASTGKIIFGGVDNAKYTGTLTALPVTS--------S 252 Candida tropicalis
P0CS83   187 NEAGG------S-----YDNvpvtLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTS--------D 247 Candida albicans
P32951   187 NEAVYdtsgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTS--------S 256 Candida parapsilosis
P32950   184 VETES------ANPP--YDNvpitLKKQGKIKTNAYSLYLNSPGAATGTIIFGGVDNAKYSGKLIEEPLVS--------D 247 Candida parapsilosis
EDN61477 178 RESVKgy---eGAPNeyYPNfpqiLKSEKIIDVVAYSLFLNSPDSGTGSIVFGAIDESKFSGDLFTFPMVNeyptivdaP 254 Saccharomyces cerev...
3FV3_A   125 NEAVYdtsgrqTTPN--YDNvpvtLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTS--------S 194 Candida parapsilosis
1J71_A   131 DEAGY------N--L--YDNvpvtLKKQGIINKNAYSLYLNSEDASTGKIIFGGVDNAKYTGTLTALPVTS--------S 192 Candida tropicalis
1PSO_E   188 GY--WQITVDSITMNGEAI-----ACAEGCQAI-------VDTGTSLLTGPTSPIANIQSDIGASENSDgd----mvVSC 249 human
P32834   286 TF--YSVNLESITVTNSTSsnnvqSSKRSSKDIevnttvtLDTGTVYIYLPEDTVESIADQYQGIVSEYgy----vvIYC 359 Schizosaccharomyces...
P22929   254 GAvaFFVELEGIEAGSSSI------TKTTYPAL-------LDSGTTLIYAPSSIASSIGREYGTYSYSYgg----yvTSC 316 Saccharomycopsis fi...
Q00663   253 VE--LRVHLGSINFDGTSV-------STNADVV-------LDSGTTITYFSQSTADKFARIVGA--TWDsrneiyrlPSC 314 Candida tropicalis
P0CS83   248 RE--LRISLGSVEVSGKTI------NTDNVDVL-------LDSGTTITYLQQDLADQIIKAFNGKLTQDsngnsfyeVDC 312 Candida albicans
P32951   257 QP--LTISLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDC 320 Candida parapsilosis
P32950   248 RY--LAVNLKSLNYNGDNS-------NAGFGVV-------VDSGTTISYLPDSIVNDLANKVGAYLEPVglgnelyfIDC 311 Candida parapsilosis
EDN61477 255 AT--LAMTIQGLGAQNKSScehetFTTTKYPVL-------LDSGTSLLNAPKVIADKMASFVNASYSEEegi---yiLDC 322 Saccharomyces cerev...
3FV3_A   195 QA--LTISLASVNLKGSSF-------SFGDGAL-------LDSGTTLTYFPSDFAAQLADKAGARLVQVardqylyfIDC 258 Candida parapsilosis
1J71_A   193 VE--LRVHLGSINFDGTSV-------STNADVV-------LDSGTTITYFSQSTADKFARIVGATWDSRnei--yrlPSC 254 Candida tropicalis
1PSO_E   250 SA-ISSLPDIVFTI-NGVQYPVPPSAYI--LQs-----eGSCISGF-QgmnlPTESGELWILGDVFIRQYF-TVFDRANN 318 human
P32834   360 DS-FSDSDYISFNFgSDADFHVSVNDLV--IYrqestsgDICYLAL------FEGDTSSYLLGQYFLQYVY-SIYDWDAQ 429 Schizosaccharomyces...
P22929   317 DA---TGPDFKFSF-NGKTITVPFSNLL--FQnse--gdSECLVGV------LSSGSNYYILGDAFLRSAY-VYYDIDNS 381 Saccharomycopsis fi...
Q00663   315 D--LSGDAVVNFD--QGVKITVPLSELI--LKds---dsSICYFGI--------SRNDANILGDNFLRRAY-IVYDLDDK 376 Candida tropicalis
P0CS83   313 N--LSGDVVFNFS--KNAKISVPASEFAasLQgddgqpyDKCQLLF--------DVNDANILGDNFLRSAY-IVYDLDDN 379 Candida albicans
P32951   321 NTdTSGTTVFNFG--NGAKITVPNTEYV--YQng----dGTCLWGI--------QPSDDTILGDNFLRHAYyLLYNLDAN 384 Candida parapsilosis
P32950   312 NAnPQGSASFTFD--NGAKITVPLSEFV--LQst----aNACVWGLqS----SDRQNVPPILGDNFLRHAYaFQLDKETV 379 Candida parapsilosis
EDN61477 323 PV-SVGDVEYNFDF-GDLQISVPLSSLI--LSpet--egSYCGFAV-------QPTNDSMVLGDVFLSSAY-VVFDLDNY 388 Saccharomyces cerev...
3FV3_A   259 NTdTSGTTVFNFG--NGAKITVPNTEYV--YQng----dGTCLWGI-Q----PSDDT---ILGDNFLRHAY-LLYNLDAN 321 Candida parapsilosis
1J71_A   255 D--LSGDAVFNFD--QGVKITVPLSELI--LKds---dsSICYFGI--------SRNDANILGDNFLRRAY-IVYDLDDK 316 Candida tropicalis
1PSO_E   319 QVGLAPV 325 human
P32834   430 KIGLAAL 436 Schizosaccharomyces pombe 972h-
P22929   382 QVGIAQA 388 Saccharomycopsis fibuligera
Q00663   377 TISLAQV 383 Candida tropicalis
P0CS83   380 EISLAQV 386 Candida albicans
P32951   385 TISIAQV 391 Candida parapsilosis
P32950   380 LSRSGEV 386 Candida parapsilosis
EDN61477 389 KISLAQA 395 Saccharomyces cerevisiae YJM789
3FV3_A   322 TISIAQV 328 Candida parapsilosis
1J71_A   317 TISLAQV 323 Candida tropicalis
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