Conserved Protein Domain Family

pfam00023: Ank 
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Ankyrin repeat
Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
PSSM-Id: 333774
View PSSM: pfam00023
Aligned: 1088 rows
Threshold Bit Score: 27.2333
Threshold Setting Gi: 795078500
Created: 13-Mar-2017
Updated: 23-May-2017
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1IHB_A         37 FGRTALQVM----KLGN--PEIAR-RLLl---rGAn-PDLKD 67   human
P25631         36 NGYTPMHAAa--aY-GH--LDLLK-KMCne-ynGd--INVLD 68   Saccharomyces cerevisiae S288c
Q24339         84 DGMAPIHAAsqmgCLD-----CLK-WMrqy-anGq--RCHAR 116  fruit fly
Q24341         84 DGMAPIH-Aa--sQMGC--LDCLK-WMVqd--qGVd-PNLRD 116  fruit fly
Q83730        141 DGYGPVQTYi---HSKNvvLDTLR-ELVr---aGAt-VHDPD 174  Myxoma virus (strain Lausanne)
Q02989        999 SECNPLHEAaayaHLD-----LVK-YFVqe--rGIn-PAEFN 1031 black widow
O41154        176 YGKTCIEMAa---YYGH--QDILKmMNGk---lGIypEAIIN 209  Paramecium bursaria Chlorella virus 1
P42771         77 TLTRPVHDAa--rE-G-----FLD-TLVvlhraGAr-LDVRD 108  human
1BD8_A         67 SGTSPVHDAa--rT-GF--LDTLK-VLVe---hGAd-VNVPD 98   human
XP_001962154  374 DGERCVHLAa---EAGH--IDILR-ILVs---hGAd-iNARE 405  Drosophila ananassae
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