5AFT,2P9K


Conserved Protein Domain Family
Actin

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pfam00022: Actin 
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Actin
Statistics
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PSSM-Id: 306521
View PSSM: pfam00022
Aligned: 27 rows
Threshold Bit Score: 384.651
Threshold Setting Gi: 75035327
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A         3 NQPVVIDNGSGVIKAGFAGDQIPK----------YCFPNYVG-----RPKHVRVMAgal---------------egDIFI 52
gi 75035327   25 TNAAVLDMGSHTTRLGFAGDTVPR----------MRQRTCVV-----KGKGTFSDAcd-----------------vLDHV 72
gi 75285838    5 SGVVVLDNGGGLLKAGFGGDMNPT----------AVVPNCMA-----KPPGSK-----------------------KWLV 46
gi 74666235   22 EKTFIIDNGAYTLKAGYAPGFPPPedlgqalsacSTIPNAIA-----KTRGN------------------------RIYI 72
gi 74656138    7 NQPVVIDNGSGNLKAGFAGEDKPK----------SYASAIIG-----RPKYQKIMAagstsll------seqqshdQLFI 65
gi 74896893    6 VQAIVIDNGSSVCKAGFGGDDAPR----------TAFPSIVG-----RPRCTGFIVdmdkkdsyfckknscfmgqkDLYI 70
gi 75030748    8 IQSVVVDVGTRNTRVGFSGEEAPR----------TMLRSCVGlpgtrRPRPTLLQH--------------------PFDI 57
gi 122019489   8 VPVVILDTGSHCLRAGYADEQGPR----------LDIPALVG-----HPRNRGVAMaag---------------mnEYEI 57
gi 122128972   8 APVVILDGGSHHLRAGYASDGAPR----------LDIPALVG-----HPRNRGVAVaag---------------mnEYEI 57
gi 47224703    6 RKVVVCDNGTGFVKCGYAGSNFPE----------HIFPALVG-----RPIIRS-----------------------TAKV 47
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A        53 GPK---AEEh--RGLLSIRYPM-EHGIVKDWNDMERIWQYVYsKEQ-LQTF--------SEEHPVLLTEAPLNPRKNRER 117
gi 75035327   73 DDPa-aATT------------VlENGVIVDWEGYEELLSRVA-RILdLENV--------ENSTPLLVTEKALVPTHQRQK 130
gi 75285838   47 ADQl-qAQDv-dVTGMTLRRPI-DRGYLINQEVQREVWERVI-RNL-LQVD--------PNNSSLLLVEPQFNPPALQHA 113
gi 74666235   73 GAQlnsQVTd--WNEMVFRRPV-EKGYIVNWEAQKEIWDNAF-FDE-KTVRskdlriesPEDTTLVLTEAPNALPTLQKN 147
gi 74656138   66 GNS---AQDn--RGLLKLSYPI-EHGIVNNWSDMEKLWYHTY-TQD-LKTQ--------SEDHPLLITEAPLNPRSNRNK 129
gi 74896893   71 GDE---AQSk--RGILNVKYPI-ERGIITNWNDMEEIWYHTF-YNE-LHVA--------PEEHPVLLTEPPLNPKANREK 134
gi 75030748   58 ATG---DAAyndGGLLSLTYPV-RAGHVCDYDALEKLLFYAL-VEE-ARVT--------PDTSPFLFLVPADQTRLDRER 123
gi 122019489  58 GEE---ALVk--RGMLTVGSPI-ENGLVVNWEHMEKLWSHVM-FSE-MRVT--------PESHCFVVPQPVNTPAAQKEK 121
gi 122128972  58 GDV---ALAk--RGMLTVSSPI-ESGRVVSWENMEKLWGHVM-YSE-LRVR--------PESHCFIVPQSVNTPASQKEK 121
gi 47224703   48 GNI-----------EIKVNYPM-ENGIVRNWDDMKHLWDYTF-GPEkLNID--------SRNCKILLTEPPMNPTKNREK 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A       118 AAEVFFETFNVPALFISMQAVLSLYATGRT------------------TGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDI 179
gi 75035327  131 IAEVLFETHRVVATSFALSPVLSLYASGLG------------------TGVAVELGHDQSHVAPVFQGLSLFHATHCLDV 192
gi 75285838  114 TDELVFEELGFKSLCVADAPSLVHLYEASRqpsl----------fraqCSLVVDCGFSFTHASPVLQNFTLNYAVRRMDL 183
gi 74666235  148 ADEIVMEEWGFGGYVRFVGPVLNAWNEVQSlfgdpigqdssspispkqCLLVVDSGYSHTTVTPVYKGQPIQRAIRRLDI 227
gi 74656138  130 MCQILFENFNIPCIYISIQAVLSLYASGRT------------------TGVVIDSGDGVTHVVPVYEGFALPPSIKRMDI 191
gi 74896893  135 MTQIMFETFKTPAIYVANQGVLSLYSTGLT------------------TGIVMNSGDGVSHTVPVYEGYILRQAILSLDL 196
gi 75030748  124 LCELLFESFNIPLAGLLTNTAATLYSSGRT------------------RGLALDSGAGRTCVAAVEEGYTLAHSVRSSSL 185
gi 122019489 122 TLELMMETFHVHSLFLGTSQVLSLYGYGLT------------------TGLVLDSGKDRTMAVPVHEGYALGRHVTESEI 183
gi 122128972 122 TLELMMETFHVHSLFLGASQVLSLYSYGLT------------------TGLVIDSGKDRTMAVPVHEGYALGRHVAESDV 183
gi 47224703  107 IIEVMFETYQFAGVYIAIQAVLTLYAQGLL------------------TGVVVDSGDGVTHICPVYEGFSLPHLTRRLDI 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A       180 AGRDVSRFLRLYLrke-----------------------------------------------gyDFHSSSEFEIVKAIK 212
gi 75035327  193 GGADLTRHFTSLMsgvatt----------------------------------------hvsvlgSMTPTQRESMWEYIK 232
gi 75285838  184 GGKALTNYLKELIsy-------------------------------------------------rSLNVMDETLLIDDAK 214
gi 74666235  228 GGKHLTNYLKEMVsm-------------------------------------------------rQYNMVDETYIMNEVK 258
gi 74656138  192 AGRDITESLAFNIrrm----------------------------------------------tgvALQSSSELEIVRLIK 225
gi 74896893  197 AGRDLTDYMNELLtdr-----------------------------------------------gyYFTTKGEKEIVRGIK 229
gi 75030748  186 AGEALTDELFAALrag-----------------------------------------------gyPLSTAADRGVVEAAK 218
gi 122019489 184 AGETLTNYLASLLrqe-----------------------------------------------gySFGTPVEMQVLNKAK 216
gi 122128972 184 AGEKLTEYFASLLrle-----------------------------------------------gySFGTPMEMQVLNNAK 216
gi 47224703  169 AGRDITRYLIKVPsgaqrrsprgahighlckamkallfsfspslclslslslllfgvqllllrgyAFNHSADFETVRMMK 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A       213 ERACYLSINPQK-----------------DETLET--------------------------EKAQ--------Y----YL 237
gi 75035327  233 ERHCTVAEDAQA-----------------FSEISRvgigmg---------------spssgSPPGsphgeedrYreecVL 280
gi 75285838  215 EKLCFVSLDVPGdl--------------rLARLSSn------------------------dNPFRc------sY----IL 246
gi 74666235  259 EAVCFVSNNFAGdl--------------eQTWQGNrkrgl-----------------tdaaEGITv------dY----VL 297
gi 74656138  226 EQNCFISKDPVRdekky--------gshySRNNPN--------------------------NELMs------tY----KL 261
gi 74896893  230 EKLSYVALDFEAe---------------mQIASAS--------------------------PALEk------sY----EL 258
gi 75030748  219 EALCRV-----------------------SADAKDeearqv---------------gthshPDPAd------gF----IL 250
gi 122019489 217 EELCYVRLNEFGvyspvhslgtlgnaaafDYNFSSsaq--------------------rpgSSPVpat--eevF----FL 270
gi 122128972 217 EDLCYVKPPIFNmtgpsa-----------ffspsEfpgecdydlslegapgegfedgredhSSDEr------vF----YL 275
gi 47224703  249 EKLCYVGYNIEQe---------------qKLALET--------------------------TVLVe------sY----TL 277
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A       238 PDG-----------------------------------------------S--TIEIGPSRFRAPELLFRPDLIGEESE- 267
gi 75035327  281 PDGt------------------------------------------------aLPISGAARFIPGECYFQPSLSPALQQl 312
gi 75285838  247 PDGitykkgfvkdldeacrysslpangesvrkdssdsdrskfedkkkpelSqnEFVLTNERFLVPEMLFHPIDLGMNQA- 325
gi 74666235  298 PDPntgkkgfmrphdplsna-------------kkrksilsggnaealseD--VLILGNERFTVPEILFTPSDIGMKQA- 361
gi 74656138  262 PDG-----------------------------------------------H--EIQLGVERFRATEILFNPQLIGHESP- 291
gi 74896893  259 PDG-----------------------------------------------Q--VITIGNERFRCPEALFRPYT------- 282
gi 75030748  251 PDQ-----------------------------------------------E--RIFLLEHAYKVPEALFDSTYLTYTTAl 281
gi 122019489 271 PDG-----------------------------------------------N--AIPLAEHRHLTTEVLFNFGIMGEEyip 301
gi 122128972 276 PDG-----------------------------------------------N--AIPISTHRSLTTEALFDFGILGSQYVp 306
gi 47224703  278 PDG-----------------------------------------------R--VIKVGGERFEAPEALFQPHLINVEGV- 307
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AFT_A       268 -----------------------GIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKl--------- 315
gi 75035327  313 rdqstvvde----vllrttqtpvSIPELVVDAMKRCDHDLLPTFASHIVVSGGASLLRGLTQRVESDVQTc--------- 379
gi 75285838  326 -----------------------GLAECIVRAIQACHPHLQPVLFERIILTGGSTLFPRFTERLEKELRPl--------- 373
gi 74666235  362 -----------------------GIPDIILQSLSVLPTGLHPSFLANVLVVGGNTLIPGFLERLESELRQi--------- 409
gi 74656138  292 -----------------------GIHELTSLAIAKTDLDLRSTLYQNIILSGGNTLLKNFGDRMLKELKDlqqplqedqk 348
gi 74896893  283 -----------------------GIHETIYNSIMKCDDDIRKDLFGSVVLSGGSTMFPGIVDRMNKELTAl--------- 330
gi 75030748  282 saerpttptgysqsnpivkktlsGWVGMLRDAADAAPRILEQALYENVVLGGGSTLFPGTEQRVQREIAGi--------- 352
gi 122019489 302 ksrymtel-----geifnpsfpmGISWLSFAAINNCQPAMRPSLFAHIVLAGGNVSFPGTRERIEAEVTRly-------- 368
gi 122128972 307 ksrymtelg-----eifqpsfpmGVSWLAFAAINNCQPVIRAQLYASIVLSGGNVSFPGTRERIETEVTQly-------- 373
gi 47224703  308 -----------------------GVAELLFNTIQAADIDTRPEFYKHIVLSGGSTMYPGLPSRLERELKQlylerv---- 360
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5AFT_A       316 -------APKDV-----KIRISAPq---ERLYSTWIGGSILASLD-TFK-KMWVSKKEYEEDGARSIHRKTF 370
gi 75035327  380 ------lASTGGihsvgSARVYADv---ERRDAAFVGGSIWASLP-AAQ-ALWVTKADYNEVGSMAVVRGGF 440
gi 75285838  374 -------VPDDY-----QVKIIAQe---DPILGAWRGGSLLAHRP-DFE-SMCITKSEYEEMGSMRCRRRFF 428
gi 74666235  410 -------ASAEC-----VVRVRRPh---DPIRSTWLGASRLAANRaELR-KFAITRQEYQEYGSSWAGRKFS 465
gi 74656138  349 msiwnknVQNDVyntkmKVKIYAPp---ERKYSTWIGGSILAGLS-TFK-KMWVTSEEYHEN-PDIVHVKCM 414
gi 74896893  331 -------APSTM-----KIKIIAPp---ERKYSVWIGGSILASLS-SFQ-PRWISKEEYDESGPSIVHRKCF 385
gi 75030748  353 -------APKGV-----RATCVAFp---ERGAAAWMGASIWGCSS-VFP-DTCLAKATYDEQGSSVVHLYTQ 407
gi 122019489 369 -----reTHASE-----AVTPICVhdveCRIYSAWLGGSMLARTS-MFP-HLTVSRQEYEEQGYRVVHCKCQ 428
gi 122128972 374 -----reTHTSE-----AVTPIAVndipCRVYSAWVGGSMLAGTS-MFP-HLAVSRQEYEEQGHRVVHCKCQ 433
gi 47224703  361 -lkgdvdKLSKF-----KIRIEDPp---RRKHMVFLGGAVLADIM-KDKdNFWLTREEYQEKGVRVLEKlgv 422
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