5AFT,2P9K


Conserved Protein Domain Family
Actin

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pfam00022: Actin 
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Actin
Statistics
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Aligned: 27 rows
Threshold Bit Score: 384.651
Threshold Setting Gi: 75035327
Created: 18-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AFT_A     3 NQPVVIDNGSGVIKAGFAGDQIPK----------YCFPNYVG-----RPKHVRVMAgal---------------egDIFI 52  pig
Q4QF49    25 TNAAVLDMGSHTTRLGFAGDTVPR----------MRQRTCVV-----KGKGTFSDAcd-----------------vLDHV 72  Leishmania major
Q5NBI2     5 SGVVVLDNGGGLLKAGFGGDMNPT----------AVVPNCMA-----KPPGSK-----------------------KWLV 46  Japanese rice
Q4W9M3    22 EKTFIIDNGAYTLKAGYAPGFPPPedlgqalsacSTIPNAIA-----KTRGN------------------------RIYI 72  Aspergillus fumigat...
Q59QT2     7 NQPVVIDNGSGNLKAGFAGEDKPK----------SYASAIIG-----RPKYQKIMAagstsll------seqqshdQLFI 65  Candida albicans
Q54HF0     6 VQAIVIDNGSSVCKAGFGGDDAPR----------TAFPSIVG-----RPRCTGFIVdmdkkdsyfckknscfmgqkDLYI 70  Dictyostelium disco...
Q4Q187     8 IQSVVVDVGTRNTRVGFSGEEAPR----------TMLRSCVGlpgtrRPRPTLLQH--------------------PFDI 57  Leishmania major
Q4D5V4     8 VPVVILDTGSHCLRAGYADEQGPR----------LDIPALVG-----HPRNRGVAMaag---------------mnEYEI 57  Trypanosoma cruzi
Q386C6     8 APVVILDGGSHHLRAGYASDGAPR----------LDIPALVG-----HPRNRGVAVaag---------------mnEYEI 57  Trypanosoma brucei
CAG00297   6 RKVVVCDNGTGFVKCGYAGSNFPE----------HIFPALVG-----RPIIRS-----------------------TAKV 47  spotted green puffe...
5AFT_A    53 GPK---AEEh--RGLLSIRYPM-EHGIVKDWNDMERIWQYVYsKEQ-LQTF--------SEEHPVLLTEAPLNPRKNRER 117 pig
Q4QF49    73 DDPa-aATT------------VlENGVIVDWEGYEELLSRVA-RILdLENV--------ENSTPLLVTEKALVPTHQRQK 130 Leishmania major
Q5NBI2    47 ADQl-qAQDv-dVTGMTLRRPI-DRGYLINQEVQREVWERVI-RNL-LQVD--------PNNSSLLLVEPQFNPPALQHA 113 Japanese rice
Q4W9M3    73 GAQlnsQVTd--WNEMVFRRPV-EKGYIVNWEAQKEIWDNAF-FDE-KTVRskdlriesPEDTTLVLTEAPNALPTLQKN 147 Aspergillus fumigat...
Q59QT2    66 GNS---AQDn--RGLLKLSYPI-EHGIVNNWSDMEKLWYHTY-TQD-LKTQ--------SEDHPLLITEAPLNPRSNRNK 129 Candida albicans
Q54HF0    71 GDE---AQSk--RGILNVKYPI-ERGIITNWNDMEEIWYHTF-YNE-LHVA--------PEEHPVLLTEPPLNPKANREK 134 Dictyostelium disco...
Q4Q187    58 ATG---DAAyndGGLLSLTYPV-RAGHVCDYDALEKLLFYAL-VEE-ARVT--------PDTSPFLFLVPADQTRLDRER 123 Leishmania major
Q4D5V4    58 GEE---ALVk--RGMLTVGSPI-ENGLVVNWEHMEKLWSHVM-FSE-MRVT--------PESHCFVVPQPVNTPAAQKEK 121 Trypanosoma cruzi
Q386C6    58 GDV---ALAk--RGMLTVSSPI-ESGRVVSWENMEKLWGHVM-YSE-LRVR--------PESHCFIVPQSVNTPASQKEK 121 Trypanosoma brucei
CAG00297  48 GNI-----------EIKVNYPM-ENGIVRNWDDMKHLWDYTF-GPEkLNID--------SRNCKILLTEPPMNPTKNREK 106 spotted green puffe...
5AFT_A   118 AAEVFFETFNVPALFISMQAVLSLYATGRT------------------TGVVLDSGDGVTHAVPIYEGFAMPHSIMRIDI 179 pig
Q4QF49   131 IAEVLFETHRVVATSFALSPVLSLYASGLG------------------TGVAVELGHDQSHVAPVFQGLSLFHATHCLDV 192 Leishmania major
Q5NBI2   114 TDELVFEELGFKSLCVADAPSLVHLYEASRqpsl----------fraqCSLVVDCGFSFTHASPVLQNFTLNYAVRRMDL 183 Japanese rice
Q4W9M3   148 ADEIVMEEWGFGGYVRFVGPVLNAWNEVQSlfgdpigqdssspispkqCLLVVDSGYSHTTVTPVYKGQPIQRAIRRLDI 227 Aspergillus fumigat...
Q59QT2   130 MCQILFENFNIPCIYISIQAVLSLYASGRT------------------TGVVIDSGDGVTHVVPVYEGFALPPSIKRMDI 191 Candida albicans
Q54HF0   135 MTQIMFETFKTPAIYVANQGVLSLYSTGLT------------------TGIVMNSGDGVSHTVPVYEGYILRQAILSLDL 196 Dictyostelium disco...
Q4Q187   124 LCELLFESFNIPLAGLLTNTAATLYSSGRT------------------RGLALDSGAGRTCVAAVEEGYTLAHSVRSSSL 185 Leishmania major
Q4D5V4   122 TLELMMETFHVHSLFLGTSQVLSLYGYGLT------------------TGLVLDSGKDRTMAVPVHEGYALGRHVTESEI 183 Trypanosoma cruzi
Q386C6   122 TLELMMETFHVHSLFLGASQVLSLYSYGLT------------------TGLVIDSGKDRTMAVPVHEGYALGRHVAESDV 183 Trypanosoma brucei
CAG00297 107 IIEVMFETYQFAGVYIAIQAVLTLYAQGLL------------------TGVVVDSGDGVTHICPVYEGFSLPHLTRRLDI 168 spotted green puffe...
5AFT_A   180 AGRDVSRFLRLYLrke-----------------------------------------------gyDFHSSSEFEIVKAIK 212 pig
Q4QF49   193 GGADLTRHFTSLMsgvatt----------------------------------------hvsvlgSMTPTQRESMWEYIK 232 Leishmania major
Q5NBI2   184 GGKALTNYLKELIsy-------------------------------------------------rSLNVMDETLLIDDAK 214 Japanese rice
Q4W9M3   228 GGKHLTNYLKEMVsm-------------------------------------------------rQYNMVDETYIMNEVK 258 Aspergillus fumigat...
Q59QT2   192 AGRDITESLAFNIrrm----------------------------------------------tgvALQSSSELEIVRLIK 225 Candida albicans
Q54HF0   197 AGRDLTDYMNELLtdr-----------------------------------------------gyYFTTKGEKEIVRGIK 229 Dictyostelium disco...
Q4Q187   186 AGEALTDELFAALrag-----------------------------------------------gyPLSTAADRGVVEAAK 218 Leishmania major
Q4D5V4   184 AGETLTNYLASLLrqe-----------------------------------------------gySFGTPVEMQVLNKAK 216 Trypanosoma cruzi
Q386C6   184 AGEKLTEYFASLLrle-----------------------------------------------gySFGTPMEMQVLNNAK 216 Trypanosoma brucei
CAG00297 169 AGRDITRYLIKVPsgaqrrsprgahighlckamkallfsfspslclslslslllfgvqllllrgyAFNHSADFETVRMMK 248 spotted green puffe...
5AFT_A   213 ERACYLSINPQK-----------------DETLET--------------------------EKAQ--------Y----YL 237 pig
Q4QF49   233 ERHCTVAEDAQA-----------------FSEISRvgigmg---------------spssgSPPGsphgeedrYreecVL 280 Leishmania major
Q5NBI2   215 EKLCFVSLDVPGdl--------------rLARLSSn------------------------dNPFRc------sY----IL 246 Japanese rice
Q4W9M3   259 EAVCFVSNNFAGdl--------------eQTWQGNrkrgl-----------------tdaaEGITv------dY----VL 297 Aspergillus fumigat...
Q59QT2   226 EQNCFISKDPVRdekky--------gshySRNNPN--------------------------NELMs------tY----KL 261 Candida albicans
Q54HF0   230 EKLSYVALDFEAe---------------mQIASAS--------------------------PALEk------sY----EL 258 Dictyostelium disco...
Q4Q187   219 EALCRV-----------------------SADAKDeearqv---------------gthshPDPAd------gF----IL 250 Leishmania major
Q4D5V4   217 EELCYVRLNEFGvyspvhslgtlgnaaafDYNFSSsaq--------------------rpgSSPVpat--eevF----FL 270 Trypanosoma cruzi
Q386C6   217 EDLCYVKPPIFNmtgpsa-----------ffspsEfpgecdydlslegapgegfedgredhSSDEr------vF----YL 275 Trypanosoma brucei
CAG00297 249 EKLCYVGYNIEQe---------------qKLALET--------------------------TVLVe------sY----TL 277 spotted green puffe...
5AFT_A   238 PDG-----------------------------------------------S--TIEIGPSRFRAPELLFRPDLIGEESE- 267 pig
Q4QF49   281 PDGt------------------------------------------------aLPISGAARFIPGECYFQPSLSPALQQl 312 Leishmania major
Q5NBI2   247 PDGitykkgfvkdldeacrysslpangesvrkdssdsdrskfedkkkpelSqnEFVLTNERFLVPEMLFHPIDLGMNQA- 325 Japanese rice
Q4W9M3   298 PDPntgkkgfmrphdplsna-------------kkrksilsggnaealseD--VLILGNERFTVPEILFTPSDIGMKQA- 361 Aspergillus fumigat...
Q59QT2   262 PDG-----------------------------------------------H--EIQLGVERFRATEILFNPQLIGHESP- 291 Candida albicans
Q54HF0   259 PDG-----------------------------------------------Q--VITIGNERFRCPEALFRPYT------- 282 Dictyostelium disco...
Q4Q187   251 PDQ-----------------------------------------------E--RIFLLEHAYKVPEALFDSTYLTYTTAl 281 Leishmania major
Q4D5V4   271 PDG-----------------------------------------------N--AIPLAEHRHLTTEVLFNFGIMGEEyip 301 Trypanosoma cruzi
Q386C6   276 PDG-----------------------------------------------N--AIPISTHRSLTTEALFDFGILGSQYVp 306 Trypanosoma brucei
CAG00297 278 PDG-----------------------------------------------R--VIKVGGERFEAPEALFQPHLINVEGV- 307 spotted green puffe...
5AFT_A   268 -----------------------GIHEVLVFAIQKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKl--------- 315 pig
Q4QF49   313 rdqstvvde----vllrttqtpvSIPELVVDAMKRCDHDLLPTFASHIVVSGGASLLRGLTQRVESDVQTc--------- 379 Leishmania major
Q5NBI2   326 -----------------------GLAECIVRAIQACHPHLQPVLFERIILTGGSTLFPRFTERLEKELRPl--------- 373 Japanese rice
Q4W9M3   362 -----------------------GIPDIILQSLSVLPTGLHPSFLANVLVVGGNTLIPGFLERLESELRQi--------- 409 Aspergillus fumigat...
Q59QT2   292 -----------------------GIHELTSLAIAKTDLDLRSTLYQNIILSGGNTLLKNFGDRMLKELKDlqqplqedqk 348 Candida albicans
Q54HF0   283 -----------------------GIHETIYNSIMKCDDDIRKDLFGSVVLSGGSTMFPGIVDRMNKELTAl--------- 330 Dictyostelium disco...
Q4Q187   282 saerpttptgysqsnpivkktlsGWVGMLRDAADAAPRILEQALYENVVLGGGSTLFPGTEQRVQREIAGi--------- 352 Leishmania major
Q4D5V4   302 ksrymtel-----geifnpsfpmGISWLSFAAINNCQPAMRPSLFAHIVLAGGNVSFPGTRERIEAEVTRly-------- 368 Trypanosoma cruzi
Q386C6   307 ksrymtelg-----eifqpsfpmGVSWLAFAAINNCQPVIRAQLYASIVLSGGNVSFPGTRERIETEVTQly-------- 373 Trypanosoma brucei
CAG00297 308 -----------------------GVAELLFNTIQAADIDTRPEFYKHIVLSGGSTMYPGLPSRLERELKQlylerv---- 360 spotted green puffe...
5AFT_A   316 -------APKDV-----KIRISAPq---ERLYSTWIGGSILASLD-TFK-KMWVSKKEYEEDGARSIHRKTF 370 pig
Q4QF49   380 ------lASTGGihsvgSARVYADv---ERRDAAFVGGSIWASLP-AAQ-ALWVTKADYNEVGSMAVVRGGF 440 Leishmania major
Q5NBI2   374 -------VPDDY-----QVKIIAQe---DPILGAWRGGSLLAHRP-DFE-SMCITKSEYEEMGSMRCRRRFF 428 Japanese rice
Q4W9M3   410 -------ASAEC-----VVRVRRPh---DPIRSTWLGASRLAANRaELR-KFAITRQEYQEYGSSWAGRKFS 465 Aspergillus fumigatus Af293
Q59QT2   349 msiwnknVQNDVyntkmKVKIYAPp---ERKYSTWIGGSILAGLS-TFK-KMWVTSEEYHEN-PDIVHVKCM 414 Candida albicans
Q54HF0   331 -------APSTM-----KIKIIAPp---ERKYSVWIGGSILASLS-SFQ-PRWISKEEYDESGPSIVHRKCF 385 Dictyostelium discoideum
Q4Q187   353 -------APKGV-----RATCVAFp---ERGAAAWMGASIWGCSS-VFP-DTCLAKATYDEQGSSVVHLYTQ 407 Leishmania major
Q4D5V4   369 -----reTHASE-----AVTPICVhdveCRIYSAWLGGSMLARTS-MFP-HLTVSRQEYEEQGYRVVHCKCQ 428 Trypanosoma cruzi
Q386C6   374 -----reTHTSE-----AVTPIAVndipCRVYSAWVGGSMLAGTS-MFP-HLAVSRQEYEEQGHRVVHCKCQ 433 Trypanosoma brucei
CAG00297 361 -lkgdvdKLSKF-----KIRIEDPp---RRKHMVFLGGAVLADIM-KDKdNFWLTREEYQEKGVRVLEKlgv 422 spotted green pufferfish
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