Conserved Protein Domain Family
Kunitz_BPTI

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pfam00014: Kunitz_BPTI 
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Kunitz/Bovine pancreatic trypsin inhibitor domain
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.
Statistics
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PSSM-Id: 278443
View PSSM: pfam00014
Aligned: 100 rows
Threshold Bit Score: 53.0271
Threshold Setting Gi: 75018850
Created: 11-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00014 is a member of the superfamily cl00101.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
4BQD_A       25 FCAFKA-DDG--P-CKa---IM--KRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCT 77
gi 75018850  22 RCSKSIfDSNltAkCE----KSstIKFHFDQSTGLCMNFRWDGCKDQENKFDSLQECASTCL 79
gi 74963214  99 LCLLDA-DQG--H-CGdernGH--WWYFFNQESGECEKFFYYGCGGNDNKFYSLHMCRKVCG 154
gi 13124580 155 FCSSPK-DEG--L-CSa---NV--TRFYFNSRNKTCETFTYTGCGGNENNFYYLDACHRACV 207
gi 74964251  18 DCTQPK-DSGn-V-CSg---SQaeRSFYFDTRMKVCQPFLYSGCGGNENRFSTSKECRDACQ 73
gi 74957115  22 DCFSAR-DTGnsG-CG----QQgaRSFYFHKNTRTCQPFFYQGCDGNSNRFQSKEACESACR 77
gi 74964245  43 DCFAAR-DSG--NtCAe---NSssRMFYYLPRLGTCQPFMYQGCGGNSNRFSSAQECRSACT 98
gi 401174   221 WCLEPA-DSG--L-CKa---SE--KRFYYNPAIGKCRQFNYTGCGGNNNNFTTKQDCNRACK 273
gi 13124581 224 WCLQPA-DSG--L-CKa---SE--RRFYYNSATGKCHRFNYTGCGGNNNNFTTRRRCLRSCK 276
gi 75052474 308 WCLTPA-DRG--L-CHa---NE--SRFYYNSVIGKCRPFKYSGCGGNENNFTSKKACLTACK 360
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