4BQD,1KTH,3L3T,5EZD,1IRH,1ZR0,1TFX,4U32


Conserved Protein Domain Family
Kunitz_BPTI

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pfam00014: Kunitz_BPTI 
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Kunitz/Bovine pancreatic trypsin inhibitor domain
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.
Statistics
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PSSM-Id: 333766
View PSSM: pfam00014
Aligned: 108 rows
Threshold Bit Score: 52.6317
Threshold Setting Gi: 75018850
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
4BQD_A         25 FCAFKADDG-PCKa------IMKRFFFNIFTRQCEEFIYGGCEGN--QNRFESLEECKKMC 76
gi 74963214    99 LCLLDADQG-HCGde---rnGHWWYFFNQESGECEKFFYYGCGGN--DNKFYSLHMCRKVC 153
gi 74963672   621 ICQEDKQAG-QCAg------NFPRYWYNHEKTQCERFIFTGCKGN--RNQFETEEECKQIC 672
gi 122114709 1286 RCSFDKDSG-SGKg------YNVKWYFNMKNLRCEQFVFEGLGGN--TNQFETLSECERIC 1337
gi 122114709 2116 VCQIKPSEGrVCNdsetptrTNLQYFYSPRDNRCKLFFFRGCGGN--LNRFERKSDCEALC 2174
gi 122114709  538 RCSLPKERG-PCDk------YELRFYFNADLNECKYFFWGGCEGN--QNNFERVEDCESAC 589
gi 28202267   293 LCLEPKVTG-GCNa------VMTRYFYNAQNGLCEQFVYDGCEGN--GNNFEKLEDCMKTC 344
gi 115114      39 FCLEPPYTG-PCKa------RIIRYFYNAKAGLCQTFVYGGCRAK--RNNFKSAEDCMRTC 90
gi 2497580     37 FCREPPYTG-PCSa------HFVRYFYNATTGLCQSFVYGGCRGK--QNNFMDEKECLHTC 88
gi 1351226     95 VCRLQVSVDdQCEg------STEKYFFNLSSMTCEKFFSGGCHRNriENRFPDEATCMGFC 149
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