5A9W,2YWE,3DEG,3J25,3J5Y,1R5B,4CRN,4TMV,4UPY,1G7S


Conserved Protein Domain Family
GTP_EFTU

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pfam00009: GTP_EFTU 
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Elongation factor Tu GTP binding domain
This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.
Statistics
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PSSM-Id: 333762
View PSSM: pfam00009
Aligned: 158 rows
Threshold Bit Score: 104.138
Threshold Setting Gi: 74676474
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A9W_A   3 EKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSraETQ---E---RV-----------MDSNDLEKERGITILAKNTAIK- 64   Shigella flexneri
Q2FZP4   8 esrkTFAIISHPDAGKTTLTEKLLYFSGAIREagTVKgkkT----Gkf-------atSDWMKVEQERGISVTSSVMQFD- 75   Staphylococcus aureu...
P73473  24 DRRRNFAIISHPDAGKTTLTEKLLLYGGAIQEagAVKarrSqrsAT-----------SDWMAMEQQRGISITSTVLQFD- 91   Synechocystis sp. PC...
P43928   9 NKRRTFAIISHPDAGKTTITEKVLLYGNAIQTagSVKgkgSaahAK-----------SDWMEMEKQRGISITTSVMQFP- 76   Haemophilus influenz...
A5EVN8  10 rdRRTFAIISHPDAGKTTLTEKLLLFGGAIALagAVKgrkAahhAT-----------SDWMKMEQERGISVTSSVMQFP- 77   Dichelobacter nodosu...
P9WNM9  21 ggVRNVVLVGPSGGGKTTLIEALLVAAKVLSRpgSVT---Eg-tTV-----------CDFDEAEIRQQRSVGLAVASLA- 84   Mycobacterium tuberc...
Q08491 265 PLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMssMRElqkKs-sNLdpsssnsfkviLDNTKTERENGFSMFKKVIQVEn 343  Saccharomyces cerevi...
O94316 139 DDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKppKRR---Sl--RY-----------TDTHYLERERVMSIKSTPLTLAv 202  Schizosaccharomyces ...
O08810 126 ELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRkrYDQdlcY----------------TDILFTEQERGVGIKSTPVTVVl 189  house mouse
Q23463 130 HIMRNVAIAGHLHHGKTTFLDCLMEQTHPEFYraEDAdarF----------------TDILFIEKQRGCSIKSQPVSIVa 193  Caenorhabditis elegans
5A9W_A  65 ----WNDYRINIVDTPGHAD-FGGEVERV--MSMVDSVLLVVDAF--------DGPMPQTRFVTKKAFAYGLK------P 123  Shigella flexneri
Q2FZP4  76 ----YDDYKINILDTPGHED-FSEDTYRT--LMAVDSAVMVIDCA--------KGIEPQTLKLFKVCKMRGIP------I 134  Staphylococcus aureu...
P73473  92 ----YRGKILNLLDTPGHQD-FSEDTYRT--LAAADNAVMLIDAA--------KGLETQTRKLFEVCRLRHLP------I 150  Synechocystis sp. PC...
P43928  77 ----YNDCLVNLLDTPGHED-FSEDTYRT--LTAVDSCLMVIDSA--------KGVEERTIKLMEVTRLRDTP------I 135  Haemophilus influenz...
A5EVN8  78 ----YHGKVINLLDTPGHED-FSEDTYRT--LTAVDSALMVIDCA--------KGVEERTIKLMEVCRLRTTP------I 136  Dichelobacter nodosu...
P9WNM9  85 ----YDGIKVNLVDTPGYAD-FVGELRAG--LRAADCALFVIAAN--------EGVDEPTKSLWQECSQVGMP------R 143  Mycobacterium tuberc...
Q08491 344 d-llPPSSTLTLIDTPGSIKyFNKETLNSilTFDPEVYVLVIDCNydswekslDGPNNQIYEILKVISYLNKNsackkhL 422  Saccharomyces cerevi...
O94316 203 sdmkGKTFAFQCIDTPGHVD-FVDEVAAP--MAISDGVVLVVDVI--------EGVMINTTRIIKHAILHDMP------I 265  Schizosaccharomyces ...
O08810 190 pdtkGKSYLFNIMDTPGHVN-FSDEVTAG--LRISDGVVLFIDAA--------EGVMLNTERLIKHAVQERLA------V 252  house mouse
Q23463 194 qdsrSKSYLLNIIDTPGHVN-FSDEMTAS--YRLADGVVVMVDAH--------EGVMMNTERAIRHAIQERLA------V 256  Caenorhabditis elegans
5A9W_A 124 IVVINKVDRP-----------GARPDWVVDQVFDLFVNL----------------------------------------- 151  Shigella flexneri
Q2FZP4 135 FTFINKLDRV-----------GKEPFELLDEIEETLNIEtypmnwpigmgqsffgiidrksktiepfrdeenil------ 197  Staphylococcus aureu...
P73473 151 FTFINKLDRP-----------SLTPLELMDEIEQELGMNtyavnypigtgdrfrgvynrltktihlfertgthgskkaa- 218  Synechocystis sp. PC...
P43928 136 ITFMNKLDRD-----------IRDPIELLDEVENVLKIRcapitwpigcgklfkgvyhlakdetylyqsgqgstiqavr- 203  Haemophilus influenz...
A5EVN8 137 FTFVNKLDRD-----------GREPMEILDEIERVLHIQcapvtwpigmgrslkgiyhlardtvyfyttgkggasinhg- 204  Dichelobacter nodosu...
P9WNM9 144 AVVITKLDHA-----------RANYREALTAAQDAFGDKvlplylpsgdgligllsqalyeyadgkrttrtpaesdteri 212  Mycobacterium tuberc...
Q08491 423 IILLNKADLIsw--------dKHRLEMIQSELNYVLke------------------------------------------ 452  Saccharomyces cerevi...
O94316 266 VLVLNKVDRL-----------ILELRLPPNDAYHKLrh------------------------------------------ 292  Schizosaccharomyces ...
O08810 253 TVCINKIDRLilelklpptdaYYKLRHIVDEVNGLISMYstdenlilspllgnvcfsssqysicftlgsfakiyadtfgd 332  house mouse
Q23463 257 TLCISKIDRLllelklppadaYFKLRLIIDQVNNILSTFaeedvpvlsplngnvifssgrynvcfsllsfsniyakqhgd 336  Caenorhabditis elegans
5A9W_A 152 --------------------------------------------------D-ATDeQld--------------------- 159  Shigella flexneri
Q2FZP4 198 ----------------------hlnddfeleedhaitndsdfeqaieelmlveeagEafdndal------------lsgd 243  Staphylococcus aureu...
P73473 219 ----------dqtmalddpalesllgsdvyaefqdelelieeagaefdlaA-VHGgEmt--------------------- 266  Synechocystis sp. PC...
P43928 204 -----------vvkglnnpeldvavgddlaqqlreelelvqgasnefeqdA-FIKgElt--------------------- 250  Haemophilus influenz...
A5EVN8 205 -----------etvvgldnprldtllpdiiddfreeihflrevgnpfdheA-YLRgel---------------------- 250  Dichelobacter nodosu...
P9WNM9 213 ---------eeargaliegiieesedeslmerylggetidesvliqdlekA-VARgsf---------------------- 260  Mycobacterium tuberc...
Q08491 453 -------------------------------------------------nFqWTDae----------------------- 460  Saccharomyces cerevi...
O94316 293 -------------------------------------------------vI-DEVnDnicqiskdlk-------yrvspe 315  Schizosaccharomyces ...
O08810 333 inyq-efakrlwgdiyfnpktrkftkkapssssqrsfvefileplykilaQ-VVGdvdtslprtldelgihltkeelkln 410  house mouse
Q23463 337 sfnskefarrlwgdiyfekktrkfvkkspshdaprtfvqfilepmykifsQ-VVGdvdtclpdvmaelgirlskeeqkmn 415  Caenorhabditis elegans
5A9W_A 160 -fpIVYASALNGIAgldhedmaedMT--------------------------------------------P-LYQAIVDH 193  Shigella flexneri
Q2FZP4 244 ltpVFFGSALANFG----------VQ--------------------------------------------N-FLNAYVDF 268  Staphylococcus aureu...
P73473 267 --pVFFGSAMNNFG----------VE--------------------------------------------L-FLQAFLQY 289  Synechocystis sp. PC...
P43928 251 --pVFFGTALGNFG----------VD--------------------------------------------H-FLDGLTQW 273  Haemophilus influenz...
A5EVN8 251 -tpVYFGSAISNFG----------VE--------------------------------------------E-MLTDFAQL 274  Dichelobacter nodosu...
P9WNM9 261 -fpVIPVCSSTGVG----------TL--------------------------------------------E-LLEVATRG 284  Mycobacterium tuberc...
Q08491 461 -fqFIPCSGLLGSN----------LNktenitkskyksef-----------------dsinyvpewyegpT-FFSQLYLL 511  Saccharomyces cerevi...
O94316 316 lgnVCFASCDLGYC----------FTlssfaklyidrhggidvdlfskrlwgdiyfdsktrkfakqsldgSgVRSFVHFI 385  Schizosaccharomyces ...
O08810 411 irpLLRLVCKKFFG----------EF--------------------------------------------TgFVDMCVQH 436  house mouse
Q23463 416 vrpLIALICKRFFG----------DF--------------------------------------------SaFVDLVVQN 441  Caenorhabditis elegans
5A9W_A 194 VPA 196  Shigella flexneri
Q2FZP4 269 APm 271  Staphylococcus aureus subsp. aureus NCTC 8325
P73473 290 AAK 292  Synechocystis sp. PCC 6803 substr. Kazusa
P43928 274 APK 276  Haemophilus influenzae Rd KW20
A5EVN8 275 APp 277  Dichelobacter nodosus VCS1703A
P9WNM9 285 FPs 287  Mycobacterium tuberculosis H37Rv
Q08491 512 VEH 514  Saccharomyces cerevisiae S288c
O94316 386 LEP 388  Schizosaccharomyces pombe 972h-
O08810 437 IPS 439  house mouse
Q23463 442 IKS 444  Caenorhabditis elegans
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