4ZUD,4N6H,2KS9,2LNL


Conserved Protein Domain Family
7tm_1

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pfam00001: 7tm_1 
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7 transmembrane receptor (rhodopsin family)
This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Statistics
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PSSM-Id: 333754
View PSSM: pfam00001
Aligned: 68 rows
Threshold Bit Score: 102.771
Threshold Setting Gi: 229463010
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ZUD_A       140 GNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVyt-amEyRWPFGNYLCKIASASVSFNLYASVFLLTCL 217
gi 68067613  100 GNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMsSLNCVFNFIfm-lnS-DWPFGSIYCTINNFVANVTVSTSVFTLVAI 177
gi 266633     49 GNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMaAFNTVVNFTya-vhN-EWYYGLFYCKFHNFFPIAAVFASIYSMTAV 126
gi 1169881    88 GNVLVCHVIFKNQRMHSATSLFIVNLAVADIMItLLNTPFTLVrf-vnS-TWVFGKGMCHVSRFAQYCSLHVSALTLTAI 165
gi 51704225  122 GNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMsFFCVPSSFIslfilN-YWPFGLALCHFVNYSQAVSVLVSAYTLVAI 200
gi 292495022  52 GNIIIVTIIRMDLHLHTPMYFFLSMLSTSETVYtLVILPRMLSslvgm--sqpiSLAGCATQMFFFVTFGITNCFLLTAM 129
gi 209572776  41 GNLTIILLSRLDARLHTPMYFFLSNLSSLDLAFtTSSVPQMLKnlwgp--dktiSYGGCVTQLYVFLWLGATECILLVVM 118
gi 129091     44 GNLAIISLVGAHRCLQTPMYFFLCNLSFLEIWFtTACVPKTLAtfapr--ggviSLAGCATQMYFVFSLGCTEYFLLAVM 121
gi 548414     41 TNLGLIALISVDLHLQTPMYIFLQNLSFTDAAYsTVITPKMLAtflee--rktiSYVGCILQYFSFVLLTVTESLLLAVM 118
2KS9_A        49 gnvvvMWIILAHKRMRTVTNYFLVNLAFAEASMaAFNTVVNFTya-vhN-EWYYGLFYCKFHNFFPIAAVFASIYSMTAV 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ZUD_A       218 SIDRYLAIVHPMKSrlRRtMLVAKVT--CIIIWLLAGLASLPAIIHRNVf-------------FIENTNITVCAFHYesq 282
gi 68067613  178 SFDRYIAIVHPLKR--RTsRRKVRII--LVLIWALSCVLSAPCLLYSSImt----------khYYNGKSRTVCFMMWpdg 243
gi 266633    127 AFDRYMAIIHPLQP--RLsATATKVV--ICVIWVLALLLAFPQGYYSTT---------------ETMPGRVVCMIEWpsh 187
gi 1169881   166 AVDRHQVIMHPLKP--RIsITKGVIY--IAVIWVMATFFSLPHAICQKLft----------fkYSEDIVRSLCLPDFpep 231
gi 51704225  201 SIDRYIAIMWPLKP--RItKRYATFI--IAGVWFIALATALPIPIVSGLdip--------mspWHTKCEKYICREMWps- 267
gi 292495022 130 GYDRYVAICNPLRY--MViMNKRLRIqlVLGACSIGLIVAITQVTSVFRlpfcark-vphffcDIRPVMKLSCIDTT--- 203
gi 209572776 119 AFDRYVAVCRPLHY--MTvMNPRLCWglAAISWLGGLGNSVIQSTFTLQlpfcghrkvdnflcEVPAMIKLACGDTS--- 193
gi 129091    122 AYDRYLAICLPLRY--GGiMTPGLAMrlALGSWLCGFSAITVPATLIARlsfcgsrvinhffcDISPWIVLSCTDTQ--- 196
gi 548414    119 AYDRYVAICKPLLY--PSiMTKAVCWrlVESLYFLAFLNSLVHTSGLLKlsfcysnvvnhffcDISPLFQISSSSIA--- 193
2KS9_A       127 AFDRYMAIIHPLQP--RLsATATKVV--ICVIWVLALLLAFPQGYYSTTe-------------TMPS--RVVCMIEWpeh 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ZUD_A       283 ---nsTLPIGLGLTKNILGFLF-PFLIILTSYTLI----WKALKK----------AYEIQKNKPRNDDI-FK---IIMAI 340
gi 68067613  244 ryptsMADYAYNLIILVLTYGI-PMIVMLICYSLMgrvlWGsrsi-------genTDRQMESMKSKRKV-VR---MFIAI 311
gi 266633    188 --pdkIYEKVYHICVTVLIYFL-PLLVIGYAYTVVgitlWAseip-------gdsSDRYHEQVSAKRKV-VK---MMIVV 253
gi 1169881   232 ---adLFWKYLDLATFILLYLL-PLFIISVAYARV----AKKLWLcnti---gdvTTEQYLALRRKKKTtVK---MLVLV 297
gi 51704225  268 ----rTQEYYYTLSLFALQFVV-PLGVLIFTYARI------TIRVwakrppgeaeTNRDQRMARSKRKM-VK---MMLTV 332
gi 292495022 204 -------VNEILTLIISVLVLVvPMGLVFISYVLI----ISTILK--------------IASVEGRKKA-FAtcaSHLTV 257
gi 209572776 194 -------LNEAVLNGVCTFFTVvPVSVILVSYCFI----AQAVMK--------------IRSVEGRRKA-FNtcvSHLVV 247
gi 129091    197 -------VVELVSFGIAFCVILgSCGITLVSYAYI----ITTIIK--------------IPSARGRHRA-FStcsSHLTV 250
gi 548414    194 -------ISELLVIISGSLFVMsSIIIILISYVFI----ILTVVM--------------IRSKDGKYKA-FStctSHLMA 247
2KS9_A       188 --pnkIYEKVYHICVTVLIYFL-PLLVIGYAYTVV----GITLWAseip---gdsSDRYHEQVSAKRKV-VK---MMIVV 253
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
4ZUD_A       341 VLFFFFSWIPHQIFTFLDVLIQLGIirdc--riadIVDTAMPITICIAYFNNCLNPLFY 397
gi 68067613  312 VSIFAICWLPYHLFFIYAYHNNQVAst-------kYVQHMYLGFYWLAMSNAMVNPLIY 363
gi 266633    254 VCTFAICWLPFHIFFLLPYINPDLYlk-------kFIQQVYLAIMWLAMSSTMYNPIIY 305
gi 1169881   298 VVLFALCWFPLNCYVLLLSSKAIHT-----------NNALYFAFHWFAMSSTCYNPFIY 345
gi 51704225  333 VIVFTCCWLPFNILQLLLNDEEFAHw--------dPLPYVWFAFHWLAMSHCCYNPIIY 383
gi 292495022 258 VIVHYSCASIAYLKPKSENTREHDQlisvtytvitP----------------LLNPVVY 300
gi 209572776 248 VFLFYGSAIYGYLLPAKSSNQSQGKfislfysvvtP----------------MVNPLIY 290
gi 129091    251 VLIWYGSTIFLHVRTSVESSLDLTKaitvlntivtP----------------VLNPFIY 293
gi 548414    248 VSLFHGTVIFMYLRPVKLFSLDTDKiaslfytvviP----------------MLNPLIY 290
2KS9_A       254 VCTFAICWLPFHIFFLLPYINPDLYlk-------kFIQQVYLAIMWLAMSSTMYNPIIY 305
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