4ZUD,4N6H,5UNF,2KS9


Conserved Protein Domain Family
7tm_1

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pfam00001: 7tm_1 
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7 transmembrane receptor (rhodopsin family)
This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Statistics
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Aligned: 68 rows
Threshold Bit Score: 113.154
Threshold Setting Gi: 229463010
Created: 13-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZUD_A 140 GNSLVVIVIYFYMK----LKT-VASVFLLNLALADLCF-LltLPLWAV-------YTAMeYRWPF---GNYL--CKIASA 201 Escherichia coli
Q6SW98  50 NAIVLITQLLTNRV----LGYsTPTIYMTNLYSTNFLT-LtvLPFIV-----------LsNQWLL---PASVasCKFLSV 110 Human herpesvirus 5 s...
P30954  52 GNIIIVTIIRMDLH----LHT-PMYFFLSMLSTSETVYtLviLPRMLS-------SLVg-MSQPI---SLAG--CATQMF 113 human
P23267  44 GNLAIISLVGAHRC----LQT-PMYFFLCNLSFLEIWFtTacVPKTLA--------TFApRGGVI---SLAG--CATQMY 105 Norway rat
P23275  41 GNLTIILLSRLDAR----LHT-PMYFFLSNLSSLDLAFtTssVPQMLK--------NLWgPDKTI---SYGG--CVTQLY 102 house mouse
P37067  41 TNLGLIALISVDLH----LQT-PMYIFLQNLSFTDAAYsTviTPKMLA-------TFLe-ERKTI---SYVG--CILQYF 102 chicken
P35408  34 GNLVAIVVLCKSRKe--qKET-TFYTLVCGLAVTDLLGtLlvSPVTIA-------TYMk-GQWPG---GQPL--CEYSTF 97  human
P21731  41 SNLLALSVLAGARQggshTRS-SFLTFLCGLVLTDFLGlLvtGTIVVS-------QHAAlFEWHAvdpGCRL--CRFMGV 110 human
P35376 379 GNILVLVILITSQY----KLT-VPRFLMCNLAFADLCIgIylLLIASVdvhtkteYHNYaIDWQT---GAG---CDAAGF 447 cattle
P06002  67 GNGVVIYIFATTKS----LRT-PANLLVINLAISDFGImItnTPMMGI--------NLYfETWVL---GPMM--CDIYAG 128 fruit fly
4ZUD_A 202 SVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHrNVf---fIENTN---ItvC 275 Escherichia coli
Q6SW98 111 IYYSSCTVGFATVALIAADRYR-VLHKRTYARQS-YRSTYIILLLTWFAGLIFSMPAAVYtTVvihngTNGQSsngHatC 188 Human herpesvirus 5 s...
P30954 114 FFVTFGITNCFLLTAMGYDRYVAICNPLRYMVIMNKRLRIQLVLGACSIGLIVAITQVTSvFRlpfcaRKVPHf----fC 189 human
P23267 106 FVFSLGCTEYFLLAVMAYDRYLAICLPLRYGGIMTPGLAMRLALGSWLCGFSAITVPATLiARlsfcgSRVIN---HffC 182 Norway rat
P23275 103 VFLWLGATECILLVVMAFDRYVAVCRPLHYMTVMNPRLCWGLAAISWLGGLGNSVIQSTFtLQlpfcgHRKVD---NflC 179 house mouse
P37067 103 SFVLLTVTESLLLAVMAYDRYVAICKPLLYPSIMTKAVCWRLVESLYFLAFLNSLVHTSGlLKlsfcySNVVN---HffC 179 chicken
P35408  98 ILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGlGSsr-lqYPDTW------C 170 human
P21731 111 VMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGvGRyt-vqYPGSW------C 183 human
P35376 448 FTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASIMLVGWIFAFAVALFPIFGiSSy-------mK---VsiC 517 cattle
P06002 129 LGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMT-IPLALGKIAYIWFMSSIWCLAPA-FgWSr---yVPEGN---LtsC 200 fruit fly
4ZUD_A 276 AFHYESqns-----tlPIGLGLTKNILGFLF-PFLIILTSYTLIWKALKKAYEIQKN----------------------- 326 Escherichia coli
Q6SW98 189 VLYFIAdevytvllswKVLLTLVWGAA-----PVIMMTWFYAFFYSTVQRASQKQRS----------------------- 240 Human herpesvirus 5 s...
P30954 190 DIRPVMklsci-dttvNEILTLIISVLVLVV-PMGLVFISYVLIISTILKIASVEGR----------------------- 244 human
P23267 183 DISPWIvlsct-dtqvVELVSFGIAFCVILG-SCGITLVSYAYIITTIIKIPSARGR----------------------- 237 Norway rat
P23275 180 EVPAMIklacg-dtslNEAVLNGVCTFFTVV-PVSVILVSYCFIAQAVMKIRSVEGR----------------------- 234 house mouse
P37067 180 DISPLFqiss--ssiaISELLVIISGSLFVMsSIIIILISYVFIILTVVMIRSKDGK----------------------- 234 chicken
P35408 171 FIDWTTnv------taHAAYSYMYAGFSSFL--ILATVLCNVLVCGALLRMHRQFMRrtslgteqhhaaaaasvasrghp 242 human
P21731 184 FLTLGAes-------gDVAFGLLFSMLGGL--SVGLSFLLNTVSVATLCHVYHGQEAaq--------------------- 233 human
P35376 518 LPMDIDs---------PLSQLYVMSLLVLNVlAFVVICGCYTHIYLTVRNPNITSSS----------------------- 565 cattle
P06002 201 GIDYLErd------wnPRSYLIFYSIFVYYI-PLFLICYSYWFIIAAVSAHEKAMREqakk------------------- 254 fruit fly
4ZUD_A 327 --------------KPR----N-----DDIFKIIMAIVLFFFF---SWIPHQIFTFLDVL------IQlgiirDCRIADI 374 Escherichia coli
Q6SW98 241 ----------------------------RTLTFVSVLLISFVA---LQTPYVSIMIFNSYata-awPM-----DCEHLTL 283 Human herpesvirus 5 s...
P30954 245 ---------------------------KKAFATCASHLTVVIV---HYSCASIAYLKPKS---------------ENTRE 279 human
P23267 238 ---------------------------HRAFSTCSSHLTVVLI---WYGSTIFLHVRTSV---------------ESSLD 272 Norway rat
P23275 235 ---------------------------RKAFNTCVSHLVVVFL---FYGSAIYGYLLPAK---------------SSNQS 269 house mouse
P37067 235 ---------------------------YKAFSTCTSHLMAVSL---FHGTVIFMYLRPVK---------------LFSLD 269 chicken
P35408 243 aaspalprlsdfrrRRSfrriA-----GAEIQMVILLIATSLVvliCSIPLVVRVFVNQL-------Y-----QPSLERE 305 human
P21731 234 -------------qRPR----------DSEVEMMAQLLGIMVVasvCWLPLLVFIAQTVLrnppamSP-----AGQLSRT 285 human
P35376 566 ---------------------Sd----TKIAKRMAMLIFTDFL---CMAPISFFAISASL---------------KVPLI 602 cattle
P06002 255 ----------mnvkSLRssedAeksaeGKLAKVALVTITLWFM---AWTPYLVINCMGLF----------------KFEG 305 fruit fly
4ZUD_A 375 VDTAMpi-tiCIAYFNNCLNPLFY 397 Escherichia coli
Q6SW98 284 RRTIGtl-srLVPHLHCLINPILY 306 Human herpesvirus 5 strain Merlin
P30954 280 HDQLIs---vTYTVITPLLNPVVY 300 human
P23267 273 LTKAIt---vLNTIVTPVLNPFIY 293 Norway rat
P23275 270 QGKFIs---lFYSVVTPMVNPLIY 290 house mouse
P37067 270 TDKIAs---lFYTVVIPMLNPLIY 290 chicken
P35408 306 VSKNPdlqaiRIASVNPILDPWIY 329 human
P21731 286 TEKELli-ylRVATWNQILDPWVY 308 human
P35376 603 TVSKSkillvLFYPINSCANPFLY 626 cattle
P06002 306 LTPLNtiwgaCFAKSAACYNPIVY 329 fruit fly
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