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Cellulose biosynthesis GIL This family of proteins includes members involved in cellulose biosynthesis such as BcsE proteins found in Salmonella typhimurium. Family members carry a GIL domain on the C-temrinal. The GIL domain, for GGDEF I-site like domain, is a c-di-GMP binding domain on the BcsE proteins of enterobacteria. It is not essentail for cellulose synthesis but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA. The RxGD motif of the GIL domain is required for c-di-GMP binding. |
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Jiyao W et al.(2023). "The conserved domain database in 2023.",