Conserved Protein Domain Family
zf-C2H2

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cl15478: zf-C2H2 Superfamily 
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Zinc finger, C2H2 type
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.
Links
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Taxonomy: root
PubMed: 2 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl15478
PSSM Id: 246975
Name: zf-C2H2
Created: 9-Oct-2011
Updated: 13-Mar-2013
Superfamily
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