5B16,2NA2,2KHX


Conserved Protein Domain Family
DSRM_RNAse_III_meta_like

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cd19877: DSRM_RNAse_III_meta_like 
double-stranded RNA binding motif of metazoan ribonuclease III (RNase III) and similar proteins
RNase III (EC 3.1.26.3; also known as Drosha, or ribonuclease 3) is a double-stranded RNA (dsRNA)-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. It is a component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNase III cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. It is also involved in pre-rRNA processing. Metazoan RNase III is a larger protein than bacterial RNase III. It contains two RNase III domains in the C-terminal half of the protein followed by a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Statistics
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PSSM-Id: 380706
Aligned: 27 rows
Threshold Bit Score: 96.575
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative RNA
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Aquifex aeolicus ribonuclease III (2EZ6) binds dsRNA

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ## ##  ##  #              #           ## # #                ####   #          
5B16_A        872 NDPKSQLQQCCLTLRteg----kepDIPLYKTLqtvGPSHARTYTVAVYFKgeRIGCGKGPSIQQAEMGAAMDALEKY 945  human
SIP63000     1232 NDPKSQLQQCCLTLRteg----kepDIPLYKTLqtvGPSHARTYTVAVYFKgeRIGCGKGPSIQQAEMGAAMDALEKY 1305 Menado coelacanth
OCT74492     1197 NDPKSQLQQCCLTLRteg----kepDIPLYKTLqtvGPSHARTYTVAVYFKgeRIGCGKGPSIQQAEMGAAMDALEKY 1270 African clawed ...
NP_001006379 1221 NDPKSQLQQCCLTLRteg----kepDIPLYKTLqtvGPSHARTYTVAVYFKgeRIGCGKGPSIQQAEMGAAMDALEKY 1294 chicken
KXJ08802       62 IDSKSQLQQCCLALRqgg----khpDLPVYKVLqdsGPSHHKKFQVGVYYKgkRVGTGEGHSLHVAEMTAAKDALASS 135  Exaiptasia pallida
PDM66844     2953 ADPKSALQQLCLALPraekgekghrLMPEYKVVaehGPTNTREYRIACVFRgkKIAEVTASNVHTAQMKAAQEGMQNL 3030 Pristionchus pa...
Q9NRR4       1259 NDPKSQLQQCCLTLRteg----kepDIPLYKTLqtvGPSHARTYTVAVYFKgeRIGCGKGPSIQQAEMGAAMDALEKY 1332 human
CEF63257      978 KDPKSYLQQYCLSKHlkpdg-sstgLLPKYKVLkkdIYNKTHYHLVAVYFNdiRVGRGLGSNIVDAAQAASSAALEYL 1054 Strongyloides r...
SYV98067     1081 LDPKTYLQQYCLSRMdn------kgNVPTYEVVgetLAGGCKQFVMGVFWRgeKIAEGIGVNHQMAQFDGAEKAKAYL 1152 Amoebidium para...
O01326        983 NDAKSHLQQWCLAMRdpss---sepDMPEYRVLgieGPTNNRIFKIAVYYKgkRLASAAESNVHKAELRVAELALANL 1057 nematode

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