1N0E,1N0E,1N0E,1N0E


Conserved Protein Domain Family
MraZ_C

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cd16321: MraZ_C 
Click on image for an interactive view with Cn3D
C-terminal subdomain of transcriptional regulator MraZ
This family contains the C-terminal domain of proteins of unknown function (UPF0040), implicated in a cellular function of bacterial cell division. It includes protein MraZ which is present in almost all bacteria and appears to be essential for survival. It is found in gene clusters associated with the cellular function of cell division and cell wall biosynthesis, including mraW, ftsI, murE, murF, ftsW and murG. Members of this family contain two tandem copies of the domain; the crystal structure of a member of this family (MPN314) reveals that the two subdomains are related by a pseudo two-fold axis, with each subdomain containing a highly conserved DXXXR sequence motif in close proximity to each other, suggested to form the functional site.
Statistics
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PSSM-Id: 293784
Aligned: 847 rows
Threshold Bit Score: 44.0071
Created: 24-Sep-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
oligomerDXXXR
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Comment:MPN314 is an octameric ring-shaped structure. Eight monomers are arranged to form a pseudo 8-fold symmetry; this octameric form is suggested to be the biological aggregation state
  • Structure:1N0E: Mycoplasma pneumoniae MPN314 (protein MraZ)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # #                             #      #           ##  #   
1N0E_G     91 RTLKRLIFAnANFVDVDtAGRVLIPN--NLINDAkldKEIVLIGQFdHLEIWDk---KLYEDYLANS 152 Mycoplasma pneumoniae
AIE88163   79 QYTRLMLGNsDDDLSFDdQGRVVVPQ--KFRTLAsltKEVVIVGCGdHLEIWDkaqhEEFEKKNDTL 143 Fimbriimonas ginsengisoli Gsoil...
CDE73214   70 QNPTTFLLShTYEVKEDgQGRITLPS--DLKKMAqidKDLVFVGKFdYAEIWAa---ETWERKFSVL 131 Acidaminococcus sp. CAG:917
KHE92785   74 TFQRLFFSMsFGVVTCDkQGRIIIPQ--QHKDYAglkRDVIIVGVMdKIEIWDs---QCWNEFEADN 135 Candidatus Scalindua brodae
EDM27214   72 ARALAAFGAkIQEVQCDkQGRVPLPA--KMKAHAgikGDAVLVGAVtTAQIWAk---QEWEASQDDE 133 Lentisphaera araneosa HTCC2155
CDE21320   66 QEAFSEYMSgFYTIEADaQGRYLLPQ--ALREYAginKNVITVGVFnRLEIWS----EEVKKEKRKQ 126 Acidiphilium sp. CAG:727
CCZ95402   67 SLLLTQLTAySRSVTADsQGRFMLPD--DLIKMMginKDVRIVGAItKAEIWSe---ERWQEKFGTG 128 Corallococcus sp. CAG:1435
CDB41514   71 AYAERIASSsKRCVIPDkQGRITLSAdhCAKAHLe--KEALIVGVGnRIEIWNp---EIWDQKCAEN 132 Ruminococcus sp. CAG:177
CDE85341   78 RRAVQRWMEqSSTFGCDkQGRVMLDE--DLLKLAgikKEVCIVGMGpTFEIWNpekrREWLGEPSES 142 Coraliomargarita sp. CAG:312
EDY19766   78 TAVLRRIGAlSRQVTLDkHGRLSLPD--EFCKQLkfsGNVTLSGVVeTFEIWNt---EEWTAAQVVQ 139 Chthoniobacter flavus Ellin428

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