1I85,1I85,1NCN


Conserved Protein Domain Family
IgV_CD86

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cd16087: IgV_CD86 
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86
The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
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PSSM-Id: 409508
Aligned: 19 rows
Threshold Bit Score: 174.051
Created: 24-Apr-2015
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     ### #        #  ##         ##      
1I85_A         2 LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQeNLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDK 81  human
AAM34433      26 MKIQAYFNSTACLPCPHSKVQNMSLSELVVFWQDQkKLVLYEHYLGREKSNSVNAKYLGRTSFDEHNWALRLPNVQITDM 105 Mongolian gerbil
BAE43062      26 VETQAYFNGTAYLPCPFTKAQNISLSELVVFWQDQqKLVLYEHYLGTEKLDSVNAKYLGRTSFDRNNWTLRLHNVQIKDM 105 house mouse
NP_001032928  22 HHVKSFLNHTAYLSCYFPNSQKTDINNVIVFWQKGtGEVVHEVYLGQEKHDHLNSKYINRTKMDMDKWTLQLLNVGIVDE 101 chicken
XP_003763688  24 LEIEAFFNKTTKLPCNFKNPQNIGPEELVIFWQGGrDCVLYEFYRGKENLMYVNSKYINRTKLNPNTWVLQLQNVQIMDQ 103 Tasmanian devil
XP_004606825   1 MTSLVYFNETGKLFCNFPNSQNLSWNELVIFWQDQdMLVLFDLLQGIEQPKSVNSKYKGRTSFDRDSWTLKLHNVQIQDK 80  European shrew
XP_004675498  20 ETSQAYFGDTGLLPCRFKNPQNTSLDELVVFWQNQ-DKVLYELYTGSENPHNVHPMYKGRTSFDLGSWTLKLHNIEIKDE 98  star-nosed mole
XP_006028620   2 LQEKAFVNHTAYLRCNFHNPDNIDVKELIVFWQKE-SEVVNEVYRGQELSDNLDPKYINRTMMDMNTWTLCLLNVGIMDE 80  Chinese alligator
XP_006091009  50 MKSQAYFNKIGDLPCHFTNPENISLDELVVFWQNQdKLVLYELFRGKENLQSVDANYKDRTSLDQDNWTLRLHNIQIKDK 129 little brown bat
XP_007536593 115 VKTQAYFNETGELPCQFKNPQNRSLNEMILFLQDQkNQVLFELYNGIEKTSNVHDSYKGRTSFDQNTWTLQLHNVQIKDR 194 western Europea...
Feature 1                                     
1I85_A        82 GLYQCIIHHKKp-TGMIRIHQMNSELSVL 109 human
AAM34433     106 GSYDCYIQQKRp-TGSVILQQTNMELSVV 133 Mongolian gerbil
BAE43062     106 GSYDCFIQKKPp-TGSIILQQTLTELSVI 133 house mouse
NP_001032928 102 GQYKCIIMHVD--KGPKKLIHESECLLNI 128 chicken
XP_003763688 104 GTYTCFVQHYGs-KGPVVIHQFSFQLSVF 131 Tasmanian devil
XP_004606825  81 GTYTCFIHHKKp-GGMIPLFQMNSELSVR 108 European shrew
XP_004675498  99 GTYYCYVHHKQrnIGMVPIYQMGFYLSVL 127 star-nosed mole
XP_006028620  81 GQYVCIIQHKKs-SGLEKIYDSKSQLFVI 108 Chinese alligator
XP_006091009 130 RLYQCFIYHRKnlQGMNLIHQNDIDLSVL 158 little brown bat
XP_007536593 195 GTYYCFIHHKRs-TGLMLIHQMISELSVI 222 western European hedgehog

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