Conserved Protein Domain Family
FYVE2_Vac1p_like

?
cd15737: FYVE2_Vac1p_like 
FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins
Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the second FYVE domain that is responsible for the ability of Pep7p to efficiently interact with Vac1p and Vps45p.
Statistics
?
PSSM-Id: 277276
Aligned: 25 rows
Threshold Bit Score: 76.0053
Created: 10-Jul-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  #  #             #  #    #            #                               
P32609       211 PWRDDrsvLFCNICSEPFgl-llRKHHCRLCGMVVCdd------anRNCSNeisigylmsaasdlpf------------- 270 Saccharomyces c...
XP_504244    243 PWQEDstqPNCPECQVKFtf-liRPHHCRVCGKVVCgq------tsTQCSLpvgvnilinsldmk--------------- 300 Yarrowia lipoly...
EAA33728     354 SWEEDgavTNCPFCKQEFgswtfRRHHCRICGKVVCad------peTACSTevgldvahptint---------------- 411 Neurospora cras...
CDK26824     326 NWQSDsevKSCRICQQRFsfgvlRKHHCRLCGLITCgd------vaTGCSMdvplnilsdllsipssfs----------- 388 Kuraishia capsu...
XP_007385799 527 PWEPDasaAACPLCAAPFhplsnRRHHCRLCGRVVCalpprapqrpVACSSlfvvsdqsgaggggaggrieevgegvdyg 606 Punctularia str...
XP_007376683 289 KWSIFi--SHCSICFVKFnl-lnRRHHCRLCGSIVCddpn---gfrKSCSMyvplnklldklpnlnys------------ 350 Spathaspora pas...
EQC36115      24 EWVPDehrTHCAVCRQSFsf-ftRKHHCRLCGEVIC----------MHCCRfvrfh------------------------ 68  Saprolegnia dic...
EPH53145     227 RWMPDisaIKCPFCGEAFgmfftRRHHCRLCGRVVCt--------gKGCSRdvvhkldarfmtldgrepdr--------- 289 Capsaspora owcz...
EQC33668     282 TTADFgdeMHCGVCLKTFgl-frRRHHCRMCAHAIC----------TQCSTnvmldqi---------------------- 328 Saprolegnia dic...
EQC38365     296 KWVRDtdrTECSVCTDTFrl-mlRRHHCRMCGEVIC----------RKCNTkvhvptgl--------------------- 343 Saprolegnia dic...
Feature 1                                     #  # 
P32609       271 -----------eyniqkddllhipisIRLCSHCI 293 Saccharomyces cerevisiae S288c
XP_504244    301 -------------eefsdtiptdcepIRICMTCK 321 Yarrowia lipolytica CLIB122
EAA33728     412 --------------ekpprivtttldIRMCRDCK 431 Neurospora crassa OR74A
CDK26824     389 --------vataskkyeklestpdasLRMCLVCK 414 Kuraishia capsulata CBS 1993
XP_007385799 607 vrrrtvgvaaaggaggmseeekflkgVRVCRECR 640 Punctularia strigosozonata HHB-11173 SS5
XP_007376683 351 ---------shvkdnfenllqddskrFRCCVNCK 375 Spathaspora passalidarum NRRL Y-27907
EQC36115      69 ----------------------dthrVRACVDCE 80  Saprolegnia diclina VS20
EPH53145     290 ------damrlllpsangtppmpsmkLLTCGDCM 317 Capsaspora owczarzaki ATCC 30864
EQC33668     329 -------------------gekgrkgVRACLHCA 343 Saprolegnia diclina VS20
EQC38365     344 -------------------ndaktcrVRVCFYCL 358 Saprolegnia diclina VS20

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap