Conserved Protein Domain Family
ePHD2_KMT2C

?
cd15697: ePHD2_KMT2C 
Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This model corresponds to the second ePHD finger of KMT2C. KMT2C, also termed myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3), or homologous to ALR protein, is a histone H3 lysine 4 (H3K4) lysine methyltransferase that functions as a circadian factor contributing to genome-scale circadian transcription. It is a component of a large complex that acts as a coactivator of multiple transcription factors, including the bile acid (BA)-activated nuclear receptor, farnesoid X receptor (FXR), a critical player in BA homeostasis. The MLL3 complex is essential for p53 transactivation of small heterodimer partner (SHP). KMT2C is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and its paralog MLL4. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis. KMT2C contains PHD fingers, two ePHD fingers, an ATPase alpha beta signature, a high mobility group (HMG)-1 box, a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain and two FY (phenylalanine tyrosine)-rich domains.
Statistics
?
PSSM-Id: 277167
Aligned: 4 rows
Threshold Bit Score: 231.09
Created: 5-Mar-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 12 residue positions
Conserved feature residue pattern:C C H C C C C C H C C HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6 (PDB 4NN2) binds three Zn2+ ions through its ePHD finger
  • Comment:The extended PHD finger is characterized by Cys2HisCys5HisCys2His.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #                       #  #                             #  #        #    #  
Q8NEZ4       4402 CCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKtGATSGCHRFRCTN 4481 human
Q4RVG0       4016 CCFCHQFGDGLTDGPARLLNLDLDVWVHLNCALWSTEVYETQAGALINVDLALRRGQSVRCAYCQHtGATSGCHRLRCTN 4095 spotted green...
ETE66201     3915 CCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKmGATSGCHRLRCTN 3994 king cobra
XP_004915562 4174 CCFCHEEGDGLTDGSARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCGFCHKtGATSSCHRLRCTN 4253 western clawe...
Feature 1           #  #               #  #
Q8NEZ4       4482 IYHFTCAIKAQCMFFKDKTMLCPMH 4506 human
Q4RVG0       4096 VYHFTCALQAQCTFFKDKTMLCHAH 4120 spotted green pufferfish
ETE66201     3995 VYHFTCAIKAQCMFFKDKTMLCPMH 4019 king cobra
XP_004915562 4254 IYHFTCAIKAQCMFFKDKTMLCTMH 4278 western clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap