Conserved Protein Domain Family
Influenza_NA

?
cd15483: Influenza_NA 
Click on image for an interactive view with Cn3D
Sialidase or neuraminidase (EC 3.2.1.18) of Influenza viruses A and B
Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates. Viral neuraminidases, such as this family from Influenza viruses A and B, play a vital role in pathogenesis. Influenza neuraminidase cleaves an alpha-ketosidic linkage between sialic acid and a neighboring sugar residue. During budding of virus particles from the infected cell, the sialidase helps to prevent the newly formed viral particles from aggregating. The viral sialidase cleaves terminal sialic acid from glycan structures on the infected cell surface, promoting virus release and the spread of virus to neighboring cells that are not yet infected. Also, sialidase modifies mucins in the respiratory tract and may improve access of the viral particle to its target cells. Sialidases have a six-bladed beta-propeller fold.
Statistics
?
PSSM-Id: 271235
View PSSM: cd15483
Aligned: 7 rows
Threshold Bit Score: 601.791
Threshold Setting Gi: 443156
Created: 27-May-2014
Updated: 11-Jun-2014
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 59 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:4H53: Influenza A virus neuraminidase contacts two neighboring molecules in the homotetramer, contacts at 4A
    View structure with Cn3D
  • Comment:based on the structure of the biological assembly for 7NN9
  • Citation:PMID 7549872

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      ##  # #  ## ##   ##            #         ## # ####        ###    
1NMB_N       84 EFNNLtKGLCTINSWHIYGKDNAVRIGED---SDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRDLI 160
1NSC_B        3 EWTYP-RLSCQGSTFQKALLISPHRFGEArgnSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLI 81
3CYE_A        1 VILTGnSSLCPISGWAIYSKDNGIRIGSK---GDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLM 77
3SAL_A        2 EFLNNtEPLCNVSGFAIVSKDNGIRIGSR---GHVFVIREPFVACGPTECRTFFLTQGALLNDKHSNNTVKDRSPYRALM 78
gi 82025081  83 EYRNWsKPQCQITGFAPFSKDNSIRLSAG---GDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRSPHRTLL 159
7NN9_A        2 DFNNLtKGLCTINSWHIYGKDNAVRIGED---SDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALI 78
4H53_A        2 EYRNWsKPQCQITGFAPFSKDNSIRLSAG---GDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNDTVHDRIPHRTLL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #### ### # #    #                ###  # # # #   ### # #                      
1NMB_N      161 SWPLSSPPTVYnSRVECiGWSSTSCHDGRARMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCQnGVCP 240
1NSC_B       82 SVKLGKIPTVEnSIFHMaAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIgGDCY 161
3CYE_A       78 SCPVGEAPSPYnSRFESvAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVnGSCF 157
3SAL_A       79 SVPLGSSPNAYqAKFESvAWSATACHDGKKWLAVGISGADDDAYAVIHYGGMPTDVVRSWRKQILRTQESSCVCMnGNCY 158
gi 82025081 160 MNELGVPFHLGtKQVCA-AWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCInGTCT 238
7NN9_A       79 SWPLSSPPTVYnSRVECiGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHnGVCP 158
4H53_A       79 MNELGVPFHLG-TRQVCiAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCInGTCT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1NMB_N      241 VVFTDGSATGPAETRIYYFKEGKILKWEPLtgtakHIEECSCYGEq-AGVTCTCRDNWQGSNRPVIQIDPvaMTHTSQYI 319
1NSC_B      162 LMITDGSASGISKCRFLKIREGRIIKEIFPtgrveHTEECTCGFAsnKTIECACRDNSYTAKRPFVKLNVetDTAEIRLM 241
3CYE_A      158 TIMTDGPSNGQASYKILKIEKGKVTKSIELnapnyHYEECSCYPDt-GKVMCVCRDNWHGSNRPWVSFDQn-LDYQIGYI 235
3SAL_A      159 WVMTDGPANSQASYKIFKSHEGMVTNEREVsfqggHIEECSCYPNl-GKVECVCRDNWNGMNRPILIFDEd-LDYEVGYL 236
gi 82025081 239 VVMTDGSASGRADTRILFIKEGKIVHIGPLsgsaqHIEECSCYPRy-PDVRCICRDNWKGSNRPVIDINMedYSIDSSYV 317
7NN9_A      159 VVFTDGSATGPAETRIYYFKEGKILKWEPLagtakHIEECSCYGEr-AEITCTCRDNWQGSNRPVIRIDPvaMTHTSQYI 237
4H53_A      158 VVMTDGSASGRADTRILFIEEGKIVHISPLsgsaqHIEECSCYPRy-PGVRCICRDNWKGSNRPVVDINMedYSIDSSYV 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1NMB_N      320 CSPVLTDNPRPNDpt-vGKCNDPYpg--nnNNGVKGFSYLDg----gNTWLGRTISIASRSGYEMLKVPnalt-ddrsKP 391
1NSC_B      242 CTETYLDTPRPDDgsitGPCESNGdk---gRGGIKGGFVHQrmaskiGRWYSRTMSKTERMGMELYVRYdgdpwtdsdAL 318
3CYE_A      236 CSGVFGDNPRPNDg--tGSCGPVSsn---gANGIKGFSFRYd----nGVWIGRTKSTSSRSGFEMIWDPngwt-etdsSF 305
3SAL_A      237 CAGIPTDTPRVQDssftGSCTNAVggsgtnNYGVKGFGFRQg----nSVWAGRTVSISSRSGFEILLIEdgwi-rtskTI 311
gi 82025081 318 CSGLVGDTPRNDDsssnSNCRDPNne--rgNPGVKGWAFDNg----dDVWMGRTISKDLRSGYETFKVIggwstpnskSQ 391
7NN9_A      238 CSPVLTDNPRPNDpt-vGKCNDPYpg--nnNNGVKGFSYLDg----vNTWLGRTISIASRSGYEMLKVPnalt-ddksKP 309
4H53_A      237 CSGLVGDTPRNDDsssnSNCRNPNne--rgTQGVKGWAFDNg----nDLWMGRTISKESRSGYETFKVIggwstpnskSQ 310
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                           #          #                             # # ###########  #
1NMB_N      392 TQGQTIVLNtdWSGYSGSFMDywae--gecyRACFYVELIRGrpkedkvwWTSNSIVSMCSSTEFLGQWNWPDGAKIEY 468
1NSC_B      319 AHSGVMVSMkePGWYSFGFEIkdk----kcdVPCIGIEMVHDggk---ktWHSAATAIYCLMGSGQLLWDTVTGVDMAL 390
3CYE_A      306 SVRQDIVAItdWSGYSGSFVQhpeltgldcmRPCFWVELIRGqpke-ntiWTSGSSISFCGVNSDTVGWSWPDGAELPF 383
3SAL_A      312 VKKVEVLNNknWSGYSGAFTIpitmtskqclVPCFWLEMIRGkpeertsiWTSSSSTVFCGVSSEVPGWSWDDGAILPF 390
gi 82025081 392 VNRQVIVDNnnWSGYSGIFSVegk----sciNRCFYVELIRGrpqetrvwWTSNSIVVFCGTSGTYGTGSWPDGANINF 466
7NN9_A      310 TQGQTIVLNtdWSGYSGSFMDywae--gecyRACFYVELIRGrpkedkvwWTSNSIVSMCSSTEFLGQWDWPDGAKIEY 386
4H53_A      311 VNRQVIVDNnnWSGDSGIFSVegk----sciNRCFYVELIRGrpqetrvwWTSNSIVVFCGTSGTYGTGSWPDGANINF 385

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap