Conserved Protein Domain Family
7tmA_GPR55-like

?
cd15165: 7tmA_GPR55-like 
G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophophatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially deorphanized as a cannabinoid receptor and binds many cannabinoid ligands.
Statistics
?
PSSM-Id: 320293
View PSSM: cd15165
Aligned: 12 rows
Threshold Bit Score: 373.979
Threshold Setting Gi: 301607610
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #  ##            ####
gi 71159390   21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKnrwpdyaaTSIYMINLAVFDLLLVLSLPFKMVLSQvqsp---fpsLCTLV 97
gi 465955301  16 SLQLVISIPTFIVGLILNLIALWVFHSWKKqt-----eSSIYMINLALADLLLLFSLPFKMYDSKkeq----nrlLCNFI 86
gi 465955300  12 LFQITVYIPTFVLGLLFNAMALWFVFCKIRkl----teSTIYLVSLITLDTLLLFTLPFKIISYGsqnkwnvgsaFCSFL 87
gi 449279863   3 LFQLIMYAPTFSLGLLFNVMALSFLFFKVKkl----seSTVYMIALIFLDTLLLFTLPFKIISYHlqnnwnlgsvFCSTL 78
gi 90652833   15 WFQRCVYVPILVFGIPLILGSLWQLLFRVRrw----seSTVYLINLIINDSLLMLSLPFKIHAYKkvwt--lgrtFCSLL 88
gi 557023541  16 SIQLVVYIPTFILGVTLNSLAIWVFCCFLKkw----seSTIYMTNLAMADLLLLISLPFKMHFSKhpwi--lskyLCSFV 89
gi 301607610  18 NVELGIYIPTFILGCILNIFALWIFFFSIKkw----teASIYLINLAILDLFLLLSLPFKMYSSIqieqi-vdrhLCTFA 92
gi 632935101  83 IIQLVVYIPTFILGVPFNLIALFFFWFKIKrr----teSVIYMSNLALADILLLLSLPFKMYYSSsrkwp-fhmaFCSFV 157
gi 573899927  12 WIQWIVYIPTFVVGLVFNLSALWILLFKIRkc----teSTVYLANLILNDSFLLFSLPFKIHSYKynwv--lgntLCSFL 85
gi 642111343   8 YVQWIVYVPTFVVGLPLNLATLWLLLFRIRrw----teSTVYLSSLIINDSLLIFSLPFKIYAFGrtwg--lsmgFCTFL 81
gi 573899929  15 SLQLVVYIPTFALGLILNSLALFVFCIQLRkw----teSTIYMTNLSLMDLLLLLSLPFKMHASQnewsv-nkkmFCTFL 89
gi 528472025  15 KLDLVIYVPILVFGLALNIMALVVFCRLLRkw----teSSIYMTNLALMDLLLLLQLPFKMHAAHhewae-dkklLCSFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ##  #                                            # #####                     
gi 71159390   98 ECLYFVSMYGSVFTICFISMDRFLAIRYPllVSHLRspRKIFGICCTIWVLVWTGSIPIYSFHgkv-------ekYMCFH 170
gi 465955301  87 EALYFVNMYGSIFIVVCISLDRYIAIRHPlkAKAFRspKQAIIVCCCVWVIVWLSSIPIYDFHnn--------dkVKCFH 158
gi 465955300  88 ESLYFVNMYGSILISACICVDRYIAIRHPflAISLRstRKAAMVCSIICMGVWAGTSFTYQFHds--------tnTTCFY 159
gi 449279863  79 ESLYFVNMYGSILISLCICVDRYITIRHPftAPTLRstKKAALVCAVICLGTSAGTVSTFQLHgeg------hniSSCFH 152
gi 90652833   89 ESLLYVNIYGSILLSVCIAVDRYIALQFPfiALRLRspRKSVIICLILWILVFACSTPIYKLHdepvn---ktdkVYCFQ 165
gi 557023541  90 ESLYFVNMYGSIFLITVISLDRYIAIRHPfkAKELRskKVAICFCIGIWIFVWLGSIPVYSFHdhs-------pnFRCFH 162
gi 301607610  93 EILYFANMYGSIYIITFISLDRYIAIKHIfwAKRLRspKKTTSICFFIWVFVWIVGGSIFKKEd----------nNRCFH 162
gi 632935101 158 ESLYFVNMYGSIFFISAISVDRYLAIIHPlrARVYRspRNSGLVCLAIWMFIWLGSIPIYNFHdspg----sngsIICFH 233
gi 573899927  86 ESLLYVNMYGSILLITCISVDRYIALRHPflAKTLRspQKAAVACFTIWIVIFGASVEVYNLHek--------naTYCFR 157
gi 642111343  82 ESLVFVNIYGSIVLIVCISGDRYVSLRFPfnGKRLRspRKAALVCLAVWVTVFAFTTPVYELHnknttslhnnneTRCFE 161
gi 573899929  90 ESLYFVSTYGSIYTIMCISIDRYIAIKHPfkAKVLRspKKALIVCAVIWVVVWTGTSPVYSFHkdkd-----anlLRCFH 164
gi 528472025  90 ESLYFVAMYGSIYTIACIALDRYFAINHPfrAKQLRskRNALIICVFIWLFVMGATSPIYTFRrek------tgnFTCFH 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #  ### ### ##                                                  #  ## ##  
gi 71159390  171 NMSddtWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILlgrrd--htqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFL 248
gi 465955301 159 NMSeqaWGIPVILSVEVFGFLIPLTLMIYCSVQIIQTLwrrkn--qgqkwAEQAASVWIILGNLMVFVVSFTPFHLGMFL 236
gi 465955300 160 GFSnktWGNPAVPIVLETAFFGSLIAMIFCTVQIIICLkrsrr--pddplTDTSKSVKIVMANLATFVVCFTPFHVMFFL 237
gi 449279863 153 NFSkstWENTGLLVALEIAFFSSMAAMTFCTVQTVRCLrkhrk--pynpqTHTSRAEKIVLTNLVAFLVCFTPYHVAYLL 230
gi 90652833  166 QFSnktWSKSWIVVSMETVFCSSTIVMVFCSVRVVQILhsmrarnpgdpkLRSNKSLKIVLSNLGVFLACFIPYHIAALI 245
gi 557023541 163 GISkssWNVVLILLVEVFGFLIPTTVVVYCSIKSIQTLldssl--tenikEKRKTCIRIIVANLTVFIISFTPNHLGIFL 240
gi 301607610 163 KMSnkiWSPSIIICLELFGFLMPMIVIMGCSIQIVRKLgdhrgi-seqdhGQKTTVRRIIISNLVVFLLSFLPSHLGIFL 241
gi 632935101 234 KFSdksWNFWLIAYVEFFGFVTPLAIVVFCSFSIIRKLlqkqip-varehQTVDSCVRIVTANLVVFIFCFAPTHLGILL 312
gi 573899927 158 GFSnrtWEKVHIVVVMETVYTASALIMIFCSIQVIRTLrtmrkrkaevqtLKNNKSVKIVLSNLVTFLVCFTPYHIAALV 237
gi 642111343 162 GFSretWGKKWIIVAMETVFTISTVTMLFFSVRVMQILsdmrrrnpldkkVRDNKSVKIVLSNLVAFMLCFIPYHVAAVV 241
gi 573899929 165 GFSeesWNPAVIINLEIFGFLIPMLVMVFCSIQIIRTLkqsqr---npdmQNNKTCIRIIYANLFVFLVSFTPSHLGIYL 241
gi 528472025 164 GFSdkgWSTALIVCLEVFGFLLPAAVLVVCSIQSIRTLkatk-----nsnRKKQAGVRIIYSSLAAFLVPFTPCHIAIFL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1        #                  ## ###  #  ##                     
gi 71159390  249 QFLvrnsfiv--ecrakqsISFFLQLSMCFSNVNCCLDVFCYYFVIkEFRMNI 299
gi 465955301 237 QFLvrqhiiv--dctvkqsISLFLQVAMCLANVNCCLDAICYYFATeEFRKKS 287
gi 465955300 238 YYLvkkevit---snlqqiIRSFVQISLCWANLNCCLDAICYYFVLkEFLKSP 287
gi 449279863 231 YFLvknniih---tsfqqvLRDTIQVTLCWANLNCCLDGVCYYFVLrESLEVP 280
gi 90652833  246 YFHaktnnwn---edtishLRYFVHVSICFSNVNILADGACYYFILkENLESA 295
gi 557023541 241 QFLvrnhiit--dcvskqnISLFVQLAMCFANVNCCLDALCYYFVTeEFREST 291
gi 301607610 242 QFLvkqdiia--ncshkqsIILFLRLSLCLANVNTCLDAACYYFAVkEFRKMS 292
gi 632935101 313 QFLvrrdiigehlcstrqnISLFIQTAMCLANVNCCLDAICYYFIAkEFRDQG 365
gi 573899927 238 YFIakkkvt-----esiqpLRDFVHLSICLTSINCLFDAICYYFIFkENWISA 285
gi 642111343 242 YFLakngten---pdvidpLRDFVHISTCLGSVNCLTDGVCYYFILkENLLTA 291
gi 573899929 242 QFLvrqnyfk--ecnttekISLFVQITMCLANITCCLDAICYYFITkELRSSS 292
gi 528472025 239 QYLvrndhil--dckkkqdIALFIQVSINIANVTCCLDALCYYFIAkEVRSTK 289

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap