Conserved Protein Domain Family
SPRY_PRY_TRIM46

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cd12895: SPRY_PRY_TRIM46 
PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of TRIM46 proteins (composed of RING/B-box/coiled-coil core and also known as RBCC proteins). The SPRY/PRY combination is a possible component of immune defense. This protein family has not yet been characterized.
Statistics
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PSSM-Id: 293952
View PSSM: cd12895
Aligned: 5 rows
Threshold Bit Score: 401.165
Threshold Setting Gi: 395532103
Created: 27-Jun-2012
Updated: 6-Nov-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47219466  496 NFYLDSRWGLhaDRLVVSKEQRGARSIPGlsllqAADHALTSCHLTsDLLVGDVAiTQGRHYWACSVEPgSYLVKVGVGL 575
gi 55976496  532 HFFLDSRWGAsrERLAISKDQRAVRSVPGlplllAADRLLTGCHLSvDVVLGDVAvTQGRSYWACAVDPaSYLVKVGVGL 611
gi 395532103 532 HFFLDGRWGSsrERLAISKDQRAVRSIPGvplllAAERLLTGCHLSvDIVLGDVAvTQGRSYWACAVDPaSYLVKVGVGL 611
gi 675309041 487 NFFLDNRWGFnrDRLAISKDQRAVRSVPGipmlfAAERLMTSCHLSiDLVIGDVAiTQGKSYWACCVDPsSYLVKVGVGL 566
gi 688598837 538 NFYLDSRWGLhaDRLVVSKEQRCARSVPGlsllqAADRALTSCHLTaDLLVGDVAiTQGRHYWACSVEPgSYLVKVGVGL 617
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47219466  576 ESKLQEWFHlPQDMASPRYDPDSGHDSGAEDNLDs-aPPFCFLTMGMGKIYLPQhtyNHHGNgtrdngp-------sspa 647
gi 55976496  612 ESKLQESFQgAPDVISPRYDPDSGHDSGAEDATVeasPPFAFLTIGMGKILLGSgasSNAGLtgrdgp----------ta 681
gi 395532103 612 ESKLQENFQgAPDVVSPRYDPDSGHDSGAEDATVeasPPFAFLTIGMGKILLGAggsGGAGLtgrdgp----------ga 681
gi 675309041 567 ESKLQEWFQvPQDVVSPRYDPDSGHDSGAEDTTVe--APPPYAFLTIGMGKILLs--HGSALtsrdp------------n 630
gi 688598837 618 ESKLQEWFHlPQDMASPRFDPDSGHDSGAEDSSDs-pPPFAFLTMGMGKIYLPSsvnSHHCNanyresgftngngpsspt 696
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47219466  648 gltYPLPPRLGVCLDFekARVTFYDAhSLRPLWEGHVDCSgPVCPAFCFIGGGALQLQEL 707
gi 55976496  682 gctVPLPPRLGICLDYerGRVSFLDAvSFRGLLECPLDCSgPVCPAFCFIGGGAVQLQEP 741
gi 395532103 682 gctVPLPPRLGICLDYerGRVSFLDAvSFRGLLECPLDCSgPVCPAFCFIGGGAVQLQEP 741
gi 675309041 631 gctVPLPPRIGICLDYeqGKVSFYDAvSFRELWECGVDCSgPVCPAFCFIGGGALHLQEL 690
gi 688598837 697 gvtYPLPPRLGVCLDFekGRVTFYDAhSLRPLWEGPVDCSaPVCPAFCFIGGGALQLQEL 756
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