Conserved Protein Domain Family
RRM2_Bruno_like
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cd12636: RRM2_Bruno_like 
RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins
This subgroup corresponds to the RRM2 of Bruno, a Drosophila RNA recognition motif (RRM)-containing protein that plays a central role in regulation of Oskar (Osk) expression. It mediates repression by binding to regulatory Bruno response elements (BREs) in the Osk mRNA 3' UTR. The full-length Bruno protein contains three RRMs, two located in the N-terminal half of the protein and the third near the C-terminus, separated by a linker region.
Links
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Statistics
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PSSM-Id: 410044
Aligned: 5 rows
Threshold Bit Score: 172.751
Created: 16-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to human CUG-binding protein 1.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # ##  #                  # # #       ### #                             # #  
XP_002589327  25 ERKLFVGMVSKKcNESDVRIMFAPYGTIEECTVLRdqngqSRGCAFVTFSTRASALNAIKALHqsqtmeGCSSPLVVKFA 104 Florida lancelet
EFX71524     100 ERKLFVGMLSKKiSENDVRIMFSAYGSIEECTVLRdnnniSRGCAFVTFTSRQSAVTAIKTVHhsqtmeGCSSPMVVKFA 179 common water flea
XP_002436197   6 ERKLFIGMLAKEcNESDVRVMFSPFGSIEECTVLRdgsgqSKGCAFVTYASRQCAINAIKAMNhsqtmkGCNNPMVVKFA 85  black-legged tick
BAK03068     123 ERKLFVGMVSKNlDEPNIRSLFQSYGTIEDCTVLRdangkSRGCAFVTFQKRQCALNAIKSMHqsqtmeGCSSPLVVKFA 202 domesticated ba...
ABS18834     141 ERKLFIGQLSKKhNEENLREIFAKFGHIEDCSVLRdqdgkSRGCAFVTFTNRSCAVVATKEMHhsqtmeGCSAPLVVKFA 220 nematode

Feature 1         
XP_002589327 105 D 105 Florida lancelet
EFX71524     180 D 180 common water flea
XP_002436197  86 D 86  black-legged tick
BAK03068     203 D 203 domesticated barley
ABS18834     221 D 221 nematode

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