Conserved Protein Domain Family
SH3_Cyk3p-like
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cd11889: SH3_Cyk3p-like 
Src Homology 3 domain of Cytokinesis protein 3 and similar proteins
Cytokinesis protein 3 (Cyk3 or Cyk3p) is a component of the actomyosin ring independent cytokinesis pathway in yeast. It interacts with Inn1 and facilitates its recruitment to the bud neck, thereby promoting cytokinesis. Cyk3p contains an N-terminal SH3 domain and a C-terminal transglutaminase-like domain. The Cyk3p SH3 domain binds to the C-terminal proline-rich region of Inn1. SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of signal pathway components and mediate multiprotein complex assemblies.
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Statistics
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PSSM-Id: 212822
Aligned: 4 rows
Threshold Bit Score: 99.4949
Created: 30-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # #  #   #                 ##               # ## 
6320086     13 KVKARYGWSGQTKGDLGFLEGDIMEVTRIa-GSWFYGKLLRnkkCSGYFPHNFV 65   baker's yeast
3183389     10 MVRALYAWPGEREGDLKFTEGDLIECLSIgdGKWWIGRHINt-nTQGIFPSNFV 62   fission yeast
CBY01620   124 WCKAVYSWGGETKRDLGFIEGDLIEVLNAgdGSWWMGRLKRdrrMVGLFPSNFV 177  blackleg of rapeseed fungus
EDK38391     8 KAKVVVSWAGEEEGDLGFLENEVVEVYSFvdDSWWSGKLRRn-gAEGIFPKEYV 60   Pichia guilliermondii ATCC 6260

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