3S4W


Conserved Protein Domain Family
FANCD2

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cd11721: FANCD2 
Click on image for an interactive view with Cn3D
Fanconi anemia D2 protein
The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.
Statistics
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PSSM-Id: 212595
Aligned: 18 rows
Threshold Bit Score: 981.413
Created: 28-Mar-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 46 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               ####                      
3S4W_B         56 PKVIEEFVNGLESYTEdseslrncllsc--------------erlqdeeasmgtFYSKSLIKLLLGID--ILQPAIIKML 119  house mouse
XP_001776368  169 ESRVDPFLLQEQDVKQktrevlmpm--------------------trisnyaesRPGVSLARTLLCIS--PIQTAVANIL 226  Physcomitrell...
EFW44312      312 PNVLGEFVDGMTDFLAdlgclqaacmp----------------lpsrnglsslkVANDSLVRLMLGVE--PIQTHLLINL 373  Capsaspora ow...
NP_001058915   86 AALRDRLLAGLAAFAEsparlrq------------------------lllptsaAHSPSLARALLSVP--ALQPGLLGLL 139  Japanese rice
EFN55133       76 GELRASFLAGLQEQLAevpvlhaalk-------------------pmqvtgnapITGDSFVRVLLNVA--PLQANVSQML 134  Chlorella var...
EFA75952      136 HVQIGNYIYGMLIQRRwlekhcftlmi----------------kltigffyvhlVPDPPQFKKSLQKDlmSLNEAKRNQF 199  Polysphondyli...
NP_001233147   73 PRNVGELFENLQIRCQdmdifkhylfpn--------------ivfrikdnseeqPSNDSVIKILLSVP--ILQPKLCDYI 136  domestic silk...
XP_001946506  121 LQNIKSKLSNDSEEIGeidmankffkefeayhndkinlkaalspyktipenkfqQQRDTLARLLLQVP--QLQSNMIDFL 198  pea aphid
EEZ97594       54 GDNVERFIKGFNILIRkekylkkallpsvfrm-------rrsggescedfgameVPQDSLFRIFLKVR--SLQPPIVEIV 124  red flour beetle
XP_003490958  204 FENEENLKNALSDMELlidge-----------------------------vsnvLHSSSLIRILLQVS--ELYPEIYSSL 252  Bombus impatiens
Feature 1                                ###  ##  #  ## #                                ##       
3S4W_B        120 FEKVPQFLFEsen--------rdGINMARLIINQLKWLDriVDGKDLTAQMMQLISVAp-VNLQHDFITSLPEILGDSQH 190  house mouse
XP_001776368  227 LEKLPEHIGEdassts--tlpalMDSIPRLILNQFKWLNflVDSKSLTEKLLEVLTICp-LALKKEIISFLPEVIVDADH 303  Physcomitrell...
EFW44312      374 LEKLPVVQDDysm-------sseEINLPRLIVAQMRWLDfvVDGRQLADKLVEVLSVTn-AEVQRELISSLPDILNDAEH 445  Capsaspora ow...
NP_001058915  140 LDKLPEHFDNvldg------mplHDDVGRLIVAQFRWLDflVDADAFVAKLMEVLSVAp-PRLKKEIIGSLPEIIGDQCH 212  Japanese rice
EFN55133      135 LERLPEFCDAqg----------eEAPLPQLILGQFRWLDhvADPRALTDKLLEVLPVCp-EELKKDAITFLPEVATEDDH 203  Chlorella var...
EFA75952      200 VEELDKYLLSdeialrislspvsSSLSDRSTHFSDSFIKilLSVPCLQSKVIDKILEK--SMDYISIMDFIPEIIDDSGH 277  Polysphondyli...
NP_001233147  137 FEKATDQATQs-----------sLEQWIQIILKCFSSLDhiVDSEKMAMNLINLLEITseKMVRLKIITAIPDIIGDQQH 205  domestic silk...
XP_001946506  199 FDKMAEINLEdtmdd----sllpVQKWVRLLIRPFKYLYtvLDLRKTCNKLFDSLYVMsdIDIKRELILSIPDIVLDSED 274  pea aphid
EEZ97594      125 LNELTTTTAVdt----------fDPGHLRLLLKQLPYLPyiKTPETLTTKLLDIIDIAp-YGAQLELLHSIPDIIPDSEH 193  red flour beetle
XP_003490958  253 LSKLNEAILIads--------ieSVSWALPLLQQFRFLDvvINSDALVNNLEQLLESCp-LWFQSELIMLLPDIVSDKQH 323  Bombus impatiens
Feature 1                               #   #                                #   #    #           
3S4W_B        191 ANVGKELGELLvQNTSLTVPILDVFSSLRLDPNFLSKIRQLVMGKLSSv-rLEDFPVIVKFLLHS--VTDTTSLEVIAEL 267  house mouse
XP_001776368  304 EMVMQALEQMLqEDLQLVVPVLDAFSNMNLEPELFEQVVTVAVSSLRTa-dAEDLPLVIKFLLQS--ATSTNVKLIIEQL 380  Physcomitrell...
EFW44312      446 RRMVDCLSMLVtSEPKLMVTILDALSNLTLPPHQVDEIRDKILKMLASv-dVSDMPVVVRFIQQF--INADNSVEVIFKL 522  Capsaspora ow...
NP_001058915  213 ATVVAALEKLLqEDSEVVVSALDALSDLNLSEQLQEQAVTVAISCIRTv-hADQMPHLLRFLLLS--ATPFNAGRIISQI 289  Japanese rice
EFN55133      204 EAVIRALEEMM-GEEAFILPSIEALANLCLTPEQQSRVVGMVLERFCTa-aAEDLPAVARFLLQYgtPADGELKKVVGTL 281  Chlorella var...
EFA75952      278 AIMVETLLAIIeEDSSYTVAVLDTLGSLTLSQSLKSKARDKIFTCLNSa-sLEELPVIINSLLQS--NSPKESSDTIKRL 354  Polysphondyli...
NP_001233147  206 NNIAMEISRILnEDHDLIPAILDCLIYLNLSDEEQDHLQKQSLNILKSltkCNYFPNFIKFLLMPsrLNENGCLAAIDGL 285  domestic silk...
XP_001946506  275 HDALEELCKLLrNDKELMATILETINQLNISKDELSLIQMDMIPVIHHt-pPDILPALVRFLIKV--YDRSVAERIVNGL 351  pea aphid
EEZ97594      194 HTVVKELAKML-DNTNISGPIIDCLNALNLTPDMRTHVQDHILSKMLA---TKLFPVYLDFLLTD--CTSKTLPGILPKL 267  red flour beetle
XP_003490958  324 QAVAEILNKILeDNSELINLILYCMGNLNLGKEYLDEYKEKTLNLLKTnvkVNAISAITKFVLED--CTNTEIFEKTLKV 401  Bombus impatiens
Feature 1                                                                #   ## #                 
3S4W_B        268 RENLNVQqfilpsriqasqskl---------kskglasssgnqenSDKDCIVLVFDVIKSAIRyeKTISEAWFKAIERIE 338  house mouse
XP_001776368  381 REHLQFVtisdvrssk--------------------pdrkqkglvSAPNCEALILEAIRSGLRlqNIACEAVLKEIRGLE 440  Physcomitrell...
EFW44312      523 RGELDFQslasttamatttttsgsrgqagrsdhsrsagfaattssTAVNGEMLTLEAIRAGLRfqQTVADAWIKVLQTVV 602  Capsaspora ow...
NP_001058915  290 RKQLKFVstvdpraar---------------------gkklkgkaSANGTDGAILDALRSGLRfkNMLCEAFLKELKSVD 348  Japanese rice
EFN55133      282 RSLHFVSpcdprlavpd-------------------rkqkgrvlgGGDSPDYRLLEAVKQAMQlnPAAADAVVREIRGTT 342  Chlorella var...
EFA75952      355 RSNLNFPpryiygsgsggt---------------ltqfnekkqkdQQNAGESLVVYSLKTNFRfkKDLCVAFLKEINSIN 419  Polysphondyli...
NP_001233147  286 RKALGWStltm-------------------------------sseDIASSQVLTAAAIRSTMIasKLVANTWLKVISQCK 334  domestic silk...
XP_001946506  352 RSELAFPtpdsis--------------------------qisttdNLLSIQLIIFNCIHDRFLscKLLLEVWMKTISQIQ 405  pea aphid
EEZ97594      268 RDALNDI--------------------------------------MSRDEDAESKISIFTKLQkwANLKPVSEAWLSLIA 309  red flour beetle
XP_003490958  402 LRNIDIQplv---------------------------------geKIEECYQSQLNIVNTLKMsmLLSKNIVNATITVIK 448  Bombus impatiens
Feature 1                                                                               #  #      
3S4W_B        339 SAAEHk-SLDVVMLLIIYSTst---qTKKGVEKLLRNKIQsdc--iqeQLLDSAFSTHYLVLKDICPSILLLAQTLFHSQ 412  house mouse
XP_001776368  441 GVQRHk-VVDIWLLLIIHANga---pHRKAAESLLKRKVIqge--ftpLLIRLCVHGRGESLQDYFKTLLSVGDSFLRSP 514  Physcomitrell...
EFW44312      603 APQDHr-VIDIFVLLMLLGLa----pSRKLAETTLRKKIKaqq--lssTLLATVFRSHSQALSTYFKELMTVAEMLLRSA 675  Capsaspora ow...
NP_001058915  349 NPRDHk-VIDVWLIMLIYGNgg---aLQKSAEKILKSKILqlc--ireTLFDQCIRGNTELVKDHFVSYLSVSDFLLACK 422  Japanese rice
EFN55133      343 EPDAHr-ILDLWLLLVMLTLga---dRRKSAEAILRRKFAdgh--adaAWLRRAITGHERVMLEFFPQLLSLAQQLLRNT 416  Chlorella var...
EFA75952      420 EAKYQ--IIDMWILFIIYSFw----nSPKDIESLIKKKIAnsl--ftkSLLISSISHHAVALKDYFKSFLSLCDCLLRTF 491  Polysphondyli...
NP_001233147  335 TSIEHk-SIDFIILLILYSTse---dRQKQVESLIKKHVKsdv--lrnDLVDEVFDRYKPILREYLKNLTDLAKAFLKSN 408  domestic silk...
XP_001946506  406 SHVEHi-PLDVVIMFLAYSAsfnvhsMKSTVLSIFKERLKngf--irsEIMVKTFQTFTPVFKQYFEMFIDLFSNLLKAT 482  pea aphid
EEZ97594      310 NTKDHk-YIDLLLLSMLHAR------KKRTIESTIRKKIKdgqfkslqVEQLFARDFPQQVFRDYFGTFCEVGSSLLRTS 382  red flour beetle
XP_003490958  449 DITKDpkPLDIILLLLISLTte---vKRKIIEAIFKQHIRsgf--yrtSLLNLLYSDYKQVVQELQPIALQISSNLLKTD 523  Bombus impatiens
Feature 1                                 #  ##      #                                   #  #  ## 
3S4W_B        413 -DQRIILFGSLLYKYAFKf--FDTYCQQEVVGALVTHVCSGteAEVDTALDVLLELIVLNASAm--RLNAAFVKGILDYL 487  house mouse
XP_001776368  515 -EVATHEFGTQVYTLLYEe-fAGDFFRREVLGSLITHIGSGisTEIGAALHTLWLIAKRKPQEl--LPMSTFLNGILDYL 590  Physcomitrell...
EFW44312      676 -EHVAQTFAADIYRNVFLh--FDGFCRQEVVGTLVTLIGAGesSRADTALQVLCDLSRTDGLRl--AEFSIFIKNILDYL 750  Capsaspora ow...
NP_001058915  423 -EEKAREFAAYLFTALFEe-fSDTFSRQELIGSLIAHIGSGvsLEVSSALDIMISLTSDKPEEl--IPLSSHITGILDYL 498  Japanese rice
EFN55133      417 -SVPVQGTGVELFCCLFQh-fTESYNQQEVLRALHSHLGAQvpAETTAALQVLLQLSDNHTDTl--GRYAAFLTNILDYI 492  Chlorella var...
EFA75952      492 -DPRIRSFGVTFYVTLFKt-fTERYYQQDIIESLTTHIGSGngSEVDEALEVLNIIAYQNVENl--LPYTTYIKGILDHI 567  Polysphondyli...
NP_001233147  409 gEMEMELFSSHIYVLMFK---ELEDCHPTIIAELLQHGLNSk-QCVSSILTTLNYVFNINKSLl--KHQSLQILSLLDRM 482  domestic silk...
XP_001946506  483 -DYVSIEVVSSMIVNCFNn--IDQCWCKWIVDELLVLLGTGnkSTIENVLNILTELTEKRIDKv-qPLATRLMYVFMNKV 558  pea aphid
EEZ97594      383 tAPTIVEFASTLFKLLFThkrTVRIYRQEVLENLIVLVGCT--DNKTAVLNIVNDLVPQILQA---PNHATILMRLLEID 457  red flour beetle
XP_003490958  524 -ERVFIDFSIDWLRLQFKchkEDAFKQREILERIIFLMGDCn-QTVKNSLAFLCKMVEKEEDRqclTPHCNHLRILLEKM 601  Bombus impatiens
Feature 1                                                                                      #  
3S4W_B        488 ENMsPQQIRKIFCILSTLAFSQqpg------------------------------------------tsNHIQDDMHLVI 525  house mouse
XP_001776368  591 EGFqDTHLHQVYSIFCHIAMAArerrg--------------------------------------asggTSVADDLLIIV 632  Physcomitrell...
EFW44312      751 DTLpLSHIRMLFSLLTTLQMARreqlrqqqnqtgaaetlrqqpsstdrtiaslmgigaasasssssfddALVEDDIYNTI 830  Capsaspora ow...
NP_001058915  499 ESFhEDNLRKVYEIFCHLALAAgfnt---------------------------------------gsggSSVANELLMVV 539  Japanese rice
EFN55133      493 DSYsDHQVQQVFAVFGLLVAGAcrqadgsg-------------------------------tsndaggrSRMEDELMIFV 541  Chlorella var...
EFA75952      568 DSLnENQIRQLFQVFGQLSYITkienapgssss--------------------------svlvytlrpnDLISSDLEIFS 621  Polysphondyli...
NP_001233147  483 DDMdLAEVRATMNLLCGLAYGIe---------------------------------------------nSFIKDDMHMII 517  domestic silk...
XP_001946506  559 HDFsSKDIAQVLDMLCKIAYSEgpdg---------------------------------------inncSVFQDEINIFV 599  pea aphid
EEZ97594      458 SFE-LKDIKLVFEILCKVTCSDds--------------------------------------------lIGLREEIHMLV 492  red flour beetle
XP_003490958  602 DNLnLKEVGTLNDLLQHLCTSSnv-------------------------------------------iaDSLRDDLFILL 638  Bombus impatiens
Feature 1         ##  # #                                                                         
3S4W_B        526 RKQLSSTVFKYKLIGIIGAVTMAGIMAedrsvpsns----------------------------------------sqrs 565  house mouse
XP_001776368  633 RKQISNPDLKYKRMGVIGVTSLVTCLGskaseedal----------------------------------------areg 672  Physcomitrell...
EFW44312      831 RKQLHSSSGKFKRVGIVGALCVIEQALnldvpnsevappldmlldvrvtldgnpdegldaakrqnknkrsaaassskprd 910  Capsaspora ow...
NP_001058915  540 RKQVSNPDMKYRRMGIIGALRIVSTIAdvnasm---------------------------------------------nc 574  Japanese rice
EFN55133      542 RKQLSSAQGQHRRIGIIGTVALVQRLGaavgvvp--------------------------------------------ep 577  Chlorella var...
EFA75952      622 RKQITNTLTKYKKIGIIAICSQVQRLAtmptsyeakilek--------------------------------hpqekekl 669  Polysphondyli...
NP_001233147  518 RKELSSSNPKIKVQGILAGVHAVKYLMieqtlenleaqs---------------------------------htknsnai 564  domestic silk...
XP_001946506  600 QKELCSLNIVSQRVGIIGAVMLIKHIVlltsddesis-------------------------------------idksnd 642  pea aphid
EEZ97594      493 RKQLSNFKQTAKERGIISAVVLAKNIAsvsgdqsdvls------------------------------------eesias 536  red flour beetle
XP_003490958  639 QKQLSNFKPFTKCKGVLGAVMAIKHLMq---------------------------------------------------- 666  Bombus impatiens
Feature 1                 ##  #      ## ##                                                        
3S4W_B        566 anvsSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFAnl--iqERKLAPKTLEWVGQTIFNDFQDAFVVDFCAApegdfp 643  house mouse
XP_001776368  673 madeESNLKEAVTLLQMTMDACKTSPVARAYFYDELSnq--leASVLHPSIIEWVVVQTEEFSTVYLGDLEGGKlpaaqd 750  Physcomitrell...
EFW44312      911 rvisDSHLSQAHELLDIVLKACDLASDCFGFFFDELSrv--vrSTRLDPRLLATLINTLHLDSYIFDLENRESEcqaltq 988  Capsaspora ow...
NP_001058915  575 sssqQPNYDEALELLKMAVNSCKFVMLPLILLYDELAvl--leNSSLHSAIVEWVGEHVAEFDTVFLADLDDGElskkyv 652  Japanese rice
EFN55133      578 esaiGKRYREAMHALQDTFHSCRHSPEAFAFLCDELTrg--iqRKAIGARLIGDVHKMLASYLEDTFFCFLKEGvqleva 655  Chlorella var...
EFA75952      670 leipDELFRLVIQLLETMLTNCRTSQVAKAYLYDEIVniynskKSTFSMKVVNWVADRLETDLRESFLQDHMSRdsdelw 749  Polysphondyli...
NP_001233147  565 chlpEGNLKEAAQIIELISQSIKQFSDMIAFFYDELSqii-smADYINPHFLSWITNAATNDWIQNFIVDRIENeiitgi 643  domestic silk...
XP_001946506  643 dillTKKAKEAYSLIELLVTRTQSDTDSQILFFDQFSlml-fhGLPLDKTFMYAVSSVMKKNFQYSFLIAANDFnnencl 721  pea aphid
EEZ97594      537 igqlTGGAKDAANLLTVVQSSTVNTPDLVSLYYDQLAami-snSDGLDKRFLAWLHERITTDFQNFYITETSDTtigdle 615  red flour beetle
XP_003490958  667 ---kTEKSDAAYNLFETVLNNVKKCSRSQALFYDQLTcii-lqTQNINTKFIKRLTDYIEEEFVITNMIDKSSYrgnlip 742  Bombus impatiens
Feature 1                                                                                         
3S4W_B        644 fpvkalygleeystqdgivin-----------------------llplfyqecakdasratsqessqrsmSSLCLASHFR 700  house mouse
XP_001776368  751 vcepvegevwmnldgdms-----------------------------piilnilpmltsssdksifsdssRSVIPGKRYY 801  Physcomitrell...
EFW44312      989 alhrlgkseftpglmgpisaalssqqqvlrqqavldalavevsfnldgdrtvgllgllgcvldskksrhdLAMLLAPNFK 1068 Capsaspora ow...
NP_001058915  653 cdgiegel------------------------------------------------wmnldgnispvfqtCLQILPSQFS 684  Japanese rice
EFN55133      656 daavhvggqrleaelwwn----------------------------ldgdttpvalrllpllaeelaldsNSAPLLSLFS 707  Chlorella var...
EFA75952      750 fndenesia----------------------------------------------viiypnlveggvhreKLICLSSHFR 783  Polysphondyli...
NP_001233147  644 klimeyglnddn----------------------------------------eviainiagitlqhdaeiSMNILSPLFQ 683  domestic silk...
XP_001946506  722 vdcslkfcldkeldeiiav---------------------------nlcpkvigeikkndnaivmglqscHSNALTSMFR 774  pea aphid
EEZ97594      616 vtkqydlngdeem---------------------------------------dapisiniaeltlrpgkhSIVALAPHFR 656  red flour beetle
XP_003490958  743 kfglnkae------------------------------------------------depenciltfedkkYGAIVPISFK 774  Bombus impatiens
Feature 1                                                                                         
3S4W_B        701 LLRLCVARQhd------gnLDEIDGLLDCplflpdlepge----------klesmsakdrsLMCSLTFLTFNWFREVVNA 764  house mouse
XP_001776368  802 VVASKNYSSqaeratnsgsLGGIDALLGCplylpkhelllg--------eqwvglsrnckeICCLSLFYAINWIRELINA 873  Physcomitrell...
EFW44312     1069 LLQLCTRSTqn------gvLDDMDGTLGFpvlfprpaqmaa---------sfgafapavrrALCLGMVHVVNWFTELLNA 1133 Capsaspora ow...
NP_001058915  685 LLTIIERLGnq------gsLGGINAVLGCplhlpstklnafstqvatrvdnvsqrarnetaVKLLMRLRNLILLEGLLNA 758  Japanese rice
EFN55133      708 TLRLMAALElal----hqnLDAVAALLGCplnlfdpalasp--------qqfkslpteqrrGVLLGLWYALNWCRELANC 775  Chlorella var...
EFA75952      784 LLQTFIRAStg-------tLDQIETLLISpidmfgldvf------------dsfqstkdkdTYALSLFYAINWVRELLNA 844  Polysphondyli...
NP_001233147  684 LVQSLHFKQnn------gdLSSIDALLGCpiimpkfdidn-----------iedldqslvsSILDCLIYSVNWFIELVNA 746  domestic silk...
XP_001946506  775 LVRGLERED----------LTEIDALLGCplvmptsktid----------efemlspeqqsVVIHTLFDAVNWFHEVINC 834  pea aphid
EEZ97594      657 LLRLVHFRQqn------gdLDTIDALLGCgvil------------------------pkqlQTTDCLLHCINWFREIISG 706  red flour beetle
XP_003490958  775 LLRTCCIKLsen-----enLDAIDSLLGCailmpkd-------------------fdiaenSVIDLIICCINWFREVISG 830  Bombus impatiens
Feature 1                                                                                         
3S4W_B        765 FCQQtsp--------------emkGKVLSRLKDLVELQGILEKYLAVIpdyvppfasvdldtld---------------- 814  house mouse
XP_001776368  874 FSTQiqarlddcd--lqltleettTKLFKRLRNLLCLEQRLNECLKAVpnlsfpqlhfltddfvgdkyekkesnpskdtq 951  Physcomitrell...
EFW44312     1134 FALRpga--------------dtqIKLLYRVTALFELLGQLGRLLPLTpdfaappatfeqadaavikhpeaapkrgtktk 1199 Capsaspora ow...
NP_001058915  759 YLKIhplslpdlryvgdhgststsKFNLPKNMGDQNMEGNVSNKRQKGhkdkasseksnsdekfkqptildafkragvti 838  Japanese rice
EFN55133      776 FAGQlapngq--------gedsvqLKLFGRLRCCCQLEAVLDVLLQHApplftlpplantldsspanlaaaaaaaapkka 847  Chlorella var...
EFA75952      845 FATQss----------------nhVKLAKKIENLIDLETKFNKVLSHCyafvvpygifnsdqrkkfsidltksk------ 902  Polysphondyli...
NP_001233147  747 FSIQsnd--------------slkTKTLKRVLNIEELQLNITEIISKCknliyksptsllhikkytsdfksrkitkssny 812  domestic silk...
XP_001946506  835 FSYLikq--------------kngDKVLIRLRTIIYLIKTIKKCLSVMyepeyipplcyyglnvekpnfiknkkkslksk 900  pea aphid
EEZ97594      707 FVLQkre--------------klrRKVLQRIDHLIELEQLFSESLDSIpkklkktnr----------------------- 749  red flour beetle
XP_003490958  831 FITQkds--------------llqKQVLQRLDNLIDLQSELSTLFSLCdtkyqpppcyfhqfplppfvridkkvgrkgk- 895  Bombus impatiens
Feature 1                                                                                         
3S4W_B            --------------------------------------------------------------------------------      house mouse
XP_001776368  952 kagqkrmpklskkekgnvkgakdp--------------------------------nagdgntqdsqrsqqgqpagtltt 999  Physcomitrell...
EFW44312     1200 gadpakgtkgktpqpnddsdiepammeptkkvksnaqsssrpppasddengengeveeehagdsddddavsvaesdlkga 1279 Capsaspora ow...
NP_001058915  839 sqetnrds----------------------------------------------------------------qpspsgmm 854  Japanese rice
EFN55133      848 gakgggkggkggkkkavkfeddgdkq---------------------------ssgspgagaasrhttsggggstvqats 900  Chlorella var...
EFA75952          --------------------------------------------------------------------------------      Polysphondyli...
NP_001233147  813 pptt------------------------------------------------------------------------skqk 820  domestic silk...
XP_001946506  901 kkntnakgkkt----------------------------------------------------------vkekknvsles 922  pea aphid
EEZ97594          --------------------------------------------------------------------------------      red flour beetle
XP_003490958      --------------------------------------------------------------------------------      Bombus impatiens
Feature 1                                                                                         
3S4W_B        815 ----------------mmprktfvslqnyraFFRELDIEVFSILHsglvtkfildt-------------------emhte 859  house mouse
XP_001776368 1000 aaeapqksgttidaaketvpwngslldeqrwKCRALTLTCTAILSmpegtvt---------------------------a 1052 Physcomitrell...
EFW44312     1280 gsvastamrraasgnfdsfarqlldlapfraCFREMDLEVFSLLAtgrrftrhllsgdepaqnvlleqnmagsstapglq 1359 Capsaspora ow...
NP_001058915  855 srvtehetnnpckfgivdlmaapaqldmqrfKFRTLHATCLSLLNysepqdt---------------------------- 906  Japanese rice
EFN55133      901 ggsmqapgpaatqgiteaaagglgrlaaerwKQRSLLLPALAVLGvgaapg----------------------------- 951  Chlorella var...
EFA75952      903 -----qkkkemqihgeesideffpfsklvkpYFRQLDLKALSVLQmyckaeqsdgvs------------------agsss 959  Polysphondyli...
NP_001233147  821 kcpdivvetlrsqatqlptsvksrldtlnsiSFRQININILLLLKsqsf------------------------------- 869  domestic silk...
XP_001946506  923 tnssnfnitnlvedenddvlenevdlsiyqnYFRELDIDTWLILTqkfvvnpdp-----------------------eqn 979  pea aphid
EEZ97594      750 -----------------------eretvldtTFREMDTDLVTLLKyplea------------------------------ 776  red flour beetle
XP_003490958  896 kekkkfkeksvsineikdwelgslicsknptYFRKFDASIVHLLDikmdmda---------------------------t 948  Bombus impatiens
Feature 1                                                                                         
3S4W_B        860 atevvqLGPAELLFLLEDLSQKLENmltapfakriccfknk-----grqnigfshlhqrsvQDIVHCVVQLL--TPMCNH 932  house mouse
XP_001776368 1053 ccadsaCQLPLYLYLLRDLYNKLDIsleqptrklapwiva------apipkvpsglgslvaTDVLKRLQTVF--PSLKRH 1124 Physcomitrell...
EFW44312     1360 pppaleFSMVHMRYMLDEMARQLKFglsppvssampflqaraskhqlhprassalemrrfeALLLAKFVALL--PHLCLH 1437 Capsaspora ow...
NP_001058915  907 tvsyneSEMPLYVYLLRELQNKLDNlypsskpffsssq-----------gkstqaycqksmEEFLNKIQPLF--SSVRKH 973  Japanese rice
EFN55133      952 qehpcyAMLPSAAYLLADVHSKLKAtlaaarrssfpgrap-------kqqqlaadvgelstEQLLGALAPVL--PAVRRH 1022 Chlorella var...
EFA75952      960 sqvlidLDPKGLHYLLDDLYAKLLVlttpektnpmllanpn-----llagsapkqhlsftlIEMITQLNGVF--PAFCIY 1032 Polysphondyli...
NP_001233147  870 ---dkdYNIKLTNFVLKCGNDILQRtmlskikkntflc-----------kqesfaydpkkaLEYAEKVNEIL--PIAMAH 933  domestic silk...
XP_001946506  980 eeftpeLGPSELRYLMEDVLQKLEHvvfknkktsplvkik------skdiigfssvslvptKTILRNFIKLL--PYLFTD 1051 pea aphid
EEZ97594      777 -thqvsLSVKQLNFILGDYVRKLSLvtkg----------------------------gdlgLSHLGAVSPLHviTDSVKT 827  red flour beetle
XP_003490958  949 qsvrcsISIKQVCFIVKELLGIFEH------------------------------------DSNEKFIKDLI--KLLPKI 990  Bombus impatiens
Feature 1                                                                                         
3S4W_B        933 LENIHNFFQCLgaehlsa-------------------------------------------------------------- 950  house mouse
XP_001776368 1125 LNSAISQLRQAiltlsgrllerteeehaaf------------------------------------------eehwmvqs 1162 Physcomitrell...
EFW44312     1438 LEDVVGLCSRYykvpsrkavakaaarakadaqmeaehgfvassqsa----------hpraddedsdgdddghgempatgs 1507 Capsaspora ow...
NP_001058915  974 LDGAVSMIKDGsdscpdnwnshs--------------------------------------------------------- 996  Japanese rice
EFN55133     1023 LDAACNIIDQElgeaalqeqdranfwelvaaggptqpsaggggggslgeaaaacmaaldqpcaaaalspvaaasrhartl 1102 Chlorella var...
EFA75952     1033 LERIVQQLPALhesitrlteeitvlksqikqtkpkdd-----------------------------edeeknkalaelqe 1083 Polysphondyli...
NP_001233147  934 LETITKYLQNNilenqs--------------------------------------------------------------- 950  domestic silk...
XP_001946506 1052 LEILSEFFKNLlmsndni-------------------------------------------------------------- 1069 pea aphid
EEZ97594      828 LPHIKRHLTAVl-------------------------------------------------------------------- 839  red flour beetle
XP_003490958  991 CAKLRDIVDVL--------------------------------------------------------------------- 1001 Bombus impatiens
Feature 1                                                                                         
3S4W_B        951 -----ddkaraTAQEQHTMACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALevlsnrlk-------------------- 1005 house mouse
XP_001776368 1163 taagnpvglvpCVSSKETAQSFLMITLRCLGKVLAYPDLTLPTNYPVFKELIsafssveganel---------------- 1226 Physcomitrell...
EFW44312     1508 gsvssqfdepmSKELAVHAAACVDLVLQCFRTFLASGAIAGQNAGQNAGSGAsgagplpaalrsfvgvlagrraqmvrai 1587 Capsaspora ow...
NP_001058915  997 asagnpdipyvVVLKSSVATSVFKEVLGCYRKLLGIPDLLNQANISVLKELLqtfqpsen-------------------- 1056 Japanese rice
EFN55133     1103 pplgrhacsmtAGPRCHPADEVRTLALDCARQLLQWPGLAEPANRPVLRAFLaafqtdaaaaaag--------------- 1167 Chlorella var...
EFA75952     1084 nlaeveakanpLLQTQSYLTSCSHLIFKSFEQIFTYGDLFSDSYGKSFQDLItsiidkqi-------------------- 1143 Polysphondyli...
NP_001233147  951 -----ndneiiYTPELINYITGLEQIYKMLTTHFRWIGFKNHHNALLKTSLKkvvnsn---------------------- 1003 domestic silk...
XP_001946506 1070 -----ldapgmFMPESYDMKHCVGLILKSLVILFQWNDFESSNTDDLFKNALkkitnrtdlss----------------- 1127 pea aphid
EEZ97594      840 ----------pECHTNDEAKATFGLVVECLCLIFNWPGLQHAKRLVLVKDIIkafrsg---------------------- 887  red flour beetle
XP_003490958 1002 -----------REENEAQSREAVRLLLCLLTKIFNWKGFESVTYNILLREGLrilasqvd-------------------- 1050 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1006 ------------------------------qmeqdqpLEELVSQSFSYLQNFHH----------SVPSFQCGLYLLRLLM 1045 house mouse
XP_001776368 1227 -------------------------aagllprpptgsLEHVFCGTYSFLDGLHAa--------aAASSLAVATQLVMVLK 1273 Physcomitrell...
EFW44312     1588 rtghdqrasgaatwrqsrdqapstsdamdeqhglrtpLPELAAEAFGYLSSIME----------AVTTLPTAATLLSCLE 1657 Capsaspora ow...
NP_001058915 1057 -----------------------------fdevlaefRPSLVPSNLDYLYCGAY----------TMFAAILDIVLNSVIM 1097 Japanese rice
EFN55133     1168 -------------------------qeaeqgppsdadLAKMVRSCFLYFIAPLPelesdqptceSPSHQHACLLMVDALL 1222 Chlorella var...
EFA75952     1144 ------------------------------sshkgqsISSQLTSLFNYFSSFWPkf-------iNNNLFKPCLSLLQLLT 1186 Polysphondyli...
NP_001233147 1004 --------------------------------ndkapLKDILLNVANVFKYHKK----------YCLQLSTAVSLVELLN 1041 domestic silk...
XP_001946506 1128 ---------------------------qstqfkrplcKKGLISDKIKYLKEFQN----------VVLHLDAAVSLVNIIQ 1170 pea aphid
EEZ97594      888 -------------------------------dselhsANHLVTELVEQLADLTQ----------FCTCLTHAVHLIQTME 926  red flour beetle
XP_003490958 1051 -----------------------------esnitlrsCKELVTECCKYFESLSD----------IITQISLSISLINMCQ 1091 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1046 ALLEksav---------------------pnqkKEKLASLAKQLLCRAWphgek-------------------------- 1078 house mouse
XP_001776368 1274 ALVDcakacenqpsderrrrssfvkiagflpllRAQLSVSAGRVLTHDWdafepwkskavfvgnaedvssaecillplti 1353 Physcomitrell...
EFW44312     1658 LFILrtrq----------------------ahlSPALCELAEHVLRRERwfhshcdtqspafvsachsssai-------- 1707 Capsaspora ow...
NP_001058915 1098 LFEKsgeqngknlhm--------gcskeiipflRKHLGLSARKLLTSDLpsedae------------------------- 1144 Japanese rice
EFN55133     1223 GLMPkvdpepter------------slkirrqmSKRISCAAEAVLKQVVvdssgkdl----------------------- 1267 Chlorella var...
EFA75952     1187 SIYEnplfgk-----------------kespdiKKTISDYAYKALRTNWsy----------------------------- 1220 Polysphondyli...
NP_001233147 1042 SIQThsnn----------------------qnmLQIVKELSHNFLSQSWktldgv------------------------- 1074 domestic silk...
XP_001946506 1171 ILKSysde----------------------penDVILRDTCWNFLTRQWysmngl------------------------- 1203 pea aphid
EEZ97594      927 ALHSitpv----------------------givRTKIAKTARELLEKQWdn----------------------------- 955  red flour beetle
XP_003490958 1092 SLMKhsesy--------------------tkenKEKYAKMAFGFLCLQWpednh-------------------------- 1125 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1079 ------------------------eknptFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELVSApkd----------- 1123 house mouse
XP_001776368 1354 llsysrseclsmrgvslltvhgfsychlhLGDMLQQLLHLHIRCNSSPIDLLEEMACNVLPQVPTKgski---------- 1423 Physcomitrell...
EFW44312     1708 -------ttamfaslttlpssptttpaplAVDAVSTAVDILLKHADNPLPMIETTIGEALALVAERhgdavpgi------ 1774 Capsaspora ow...
NP_001058915 1145 ------------------------ngwqsKGDLIQKILQIYLKNSDSTSDLLDELACSVLPKVPSFktgst--------- 1191 Japanese rice
EFN55133     1268 ----------------------ggavwkgRGPLLADVLRLYLSHYGTRRGDGGGSPVDAVLDLACNrlprvadst---ka 1322 Chlorella var...
EFA75952     1221 ---------------------------kiSSVSISYLIKAYIHFHDDQLGVIDKLTETLQNFLNVDkstkkkkndededm 1273 Polysphondyli...
NP_001233147 1075 -----------------------pekgltFNQNIDFLASIYFINNEILDLKTMSLELAHDIKLLESknd----------- 1120 domestic silk...
XP_001946506 1204 -----------------------eengpkYNDQIKFLLEIYLQCHTDKLKKLVEMVDWLEEEVLVMeskt---------- 1250 pea aphid
EEZ97594      956 ----------------------------ySSSNIDVLVRSYLSSASVKTLCGIVGTVQEQAPGLTKse------------ 995  red flour beetle
XP_003490958 1126 -------------------------sstqYKSTVIELLNSWINNELLPLQTVTSILDWLPDETSELekpq---------- 1170 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1124 ----aasSTFPTLTRHTFVIFFRVMMAELEKTVKGLqagta--------------adsqQVHEEKLLYWNMAVRDFSILL 1185 house mouse
XP_001776368 1424 ---nqgvEGYPALSYSTFLIWYRVQMKEVLSQIKSKnpl------------------vkDAVVELLTSAHHCIKVHVALV 1482 Physcomitrell...
EFW44312     1775 khaeisvPFLPTLSKRSLPAFFRASLDGVTGALRELdsvrelg----------vlvsgeGNANVQMVKLQSCVFNFWRLC 1844 Capsaspora ow...
NP_001058915 1192 ---qdmsHGFPTLCASTILSWYRVVHEENTGNLNKMikqalk-----------tkaqseRAVETSLEEIQKSVLVFVSLI 1257 Japanese rice
EFN55133     1323 keaseavDPFPSLSGNTVSIWYRVCLEQLQVGWEGVaaaaagaekhgaamkdeealetiLGGMQASRAGGSCASAFCALM 1402 Chlorella var...
EFA75952     1274 dqsdendQILPVLHTHSALVFFKTLFSLLIVVFEKQnfs------------------npADMDATIDRLKYFTRIFKALV 1335 Polysphondyli...
NP_001233147 1121 -----tlRGLKCINKVNFPIIFRNLGTAVFEAAKRRld-------------------kgMTNAEHLVLWRDIADILKSMT 1176 domestic silk...
XP_001946506 1251 ----dklKTLPTIKKINFKILIKVVLNSLLESVKNDlk-------------------taESEMDRLIIWQSAIYVMEKIV 1307 pea aphid
EEZ97594      996 -----plEMLKSVTKTNFFVFYRNLWACLHDRVKSEt---------------------nAQHVATWRTIALTMQGLMAVA 1049 red flour beetle
XP_003490958 1171 ----drlSRMPSISRSSFHFLFKKMFDGLINGIKTAlq-------------------iaDRDPKRIGVWYEVARNVQKLV 1227 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1186 Nlmkvfds-ypvlhvCLKYGRRFVEAFLKQCMPLLDf-sFRKHREDVLSLLQTLQLNTRLLHHLCghski---------- 1253 house mouse
XP_001776368 1483 Nltkshek-savhavAVKCGGKFVDTFLKGMDFFQAk--FEAHKDIIVSSVKELQKATRIVQTICaeakigthfglfsdp 1559 Physcomitrell...
EFW44312     1845 Sfvakysh-rlvllaVVKGGRQFVDTFLKVGMPFIDv-hFIEMREPMTEMFKKLQQATRSLQMVCghtkv---------- 1912 Capsaspora ow...
NP_001058915 1258 Nmckthek-vvmhamAVKHGGRFVDTFLKAFNFLETh--FGQHNDIILQMIKSLQKATKTIQTICaeakg---------- 1324 Japanese rice
EFN55133     1403 SvvkrqtqrvaihvqAVKSGGKFLLTFFKTLPFWSQl--FPERQEAFQEMVKYIQRGTRTLQYLCsegkf---------- 1470 Chlorella var...
EFA75952     1336 Dftkhkk--shylveTLRYGKNFVTSYTKAIVPILKpllKYNMYDTIENAISQFQGSCRILQHICtygkk---------- 1403 Polysphondyli...
NP_001233147 1177 Eivktqk--snsltaFFKNSMPILRLFTLQGIPILKl-eFKNQTDEVLQILKILQQSTRFLHSLCchsrl---------- 1243 domestic silk...
XP_001946506 1308 Qtikkqds-rdnlliFVKGSILLLKLFLAEGMTVCQn-lFKVRTKEVSKVLKNLQVITRYIQNICnytkv---------- 1375 pea aphid
EEZ97594     1050 Kaqktk----pnlvyCLKKSTAILKLFLTHGIPILEi-eFKAKSELVIEIFKTMHSNARFLHHLCcyska---------- 1114 red flour beetle
XP_003490958 1228 Qicktltt-knnlliFLKYMPILLKSFLNLGMPVLEh-nLKYQTEEVTKILKMMQGGTRYLHTICcdsae---------- 1295 Bombus impatiens
Feature 1                                                                                         
3S4W_B       1254 --------rqdtRLTKHVPLLKKSLELLVCRVKAMLVLnncrEAFWLGT------------------------------- 1294 house mouse
XP_001776368 1560 easlvgqghkrmPVATKVPAVKRSMEKFIFCVKALLHGasngSAFWMGN------------------------------- 1608 Physcomitrell...
EFW44312     1913 --------vrdvSVLAQVPPLRKSLETLIFRVKVMFEVngvrVAFSIGN------------------------------- 1953 Capsaspora ow...
NP_001058915 1325 --------hkrtMITSKIPVAKRSLERFVFQVKALLHNcsteETFWMGTyilctpnfcswqrreiyidgrhccsnllnrc 1396 Japanese rice
EFN55133     1471 --------rkemPLTARVPAVKRTVERFMFLIKAFLTEanagGAFWMGS------------------------------- 1511 Chlorella var...
EFA75952     1404 --------qkdtSLTKLIPQVKKCVETFLVEVKLVLTAmnclGAFSTAS------------------------------- 1444 Polysphondyli...
NP_001233147 1244 --------kknkALLNKVPFVKKILETLIYQVKAALAAnncsEAFWMGN------------------------------- 1284 domestic silk...
XP_001946506 1376 --------vkdnALSNCLPNIRGILEALILKVKNVIVMngctDALFMGI------------------------------- 1416 pea aphid
EEZ97594     1115 --------tkdvGLISHVPQFRLTFETLVYRVKAALAAngcsAAFWMGN------------------------------- 1155 red flour beetle
XP_003490958 1296 --------kkdlTLSKYIPAAKSILERLIYSVKGMLVLnnspTAFWMGN------------------------------- 1336 Bombus impatiens
Feature 1                            
3S4W_B       1295 ----LKNRDLQGEEIISQD 1309 house mouse
XP_001776368 1609 ----LKHKDLQGREVASQL 1623 Physcomitrella patens subsp. patens
EFW44312     1954 ----LKHKSIRGEEVSSQG 1968 Capsaspora owczarzaki ATCC 30864
NP_001058915 1397 mtgnLRHKDLQGQLVSSQV 1415 Japanese rice
EFN55133     1512 ----LKHRDLTGREVPSQM 1526 Chlorella variabilis
EFA75952     1445 ----LKKKTLQGVVINEDI 1459 Polysphondylium pallidum PN500
NP_001233147 1285 ----LKNKDIHGEVIASQE 1299 domestic silkworm
XP_001946506 1417 ----MKNMDIKGDEIMSQN 1431 pea aphid
EEZ97594     1156 ----LRNRDLDGEDILSES 1170 red flour beetle
XP_003490958 1337 ----LVNKNLEGQEIFSQN 1351 Bombus impatiens

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