3SHG


Conserved Protein Domain Family
VbhA_like
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cd11586: VbhA_like 
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VbhA antitoxin and related proteins
VbhA is the antitoxin to VbhT. The VbhT toxin of the mammalian pathogen Bartonella schoenbuchensis is responsible for the disruptive adenylation of host proteins. VbhT also induces FIC-domain-mediated growth arrest in bacteria; it is inhibited by this antitoxin which binds to block the ATP binding site of the VbhT FIC domain.
Links
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Statistics
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PSSM-Id: 212155
Aligned: 59 rows
Threshold Bit Score: 30.1523
Created: 14-Mar-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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FIC domain
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1: FIC domain binding interface [polypeptide binding site], 29 residue positions
Conserved feature residue pattern:x x x x x x x x x x [STN] x x x E [GN] x x x x x x x x x x x x xClick to see conserved feature residue pattern help
Evidence:
  • Comment:A conserved glutamate sidechain occupies the site that otherwise binds the ATP-gamma-phosphate in the FIC domain binding interface
  • Structure:3SHB: Bartonella schoenbuchensis VbhA binds the VbhT FIC domain, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  ## ### ##############  #   #  #      #  ##  ##  #
3SHG_B         4 EEEIEYRRRDARNALASQRLEGLEPDPQVVAQMERVVVGELETSDVIKDLMERI 57  Bartonella schoenbuchensis R1
ZP_03719703    6 QEQQHHLPQTTHSIIGSWRMEQLNISPETIRDMQHLAEGKISLDDALDGIKQRM 59  Neisseria flavescens NRL30031/H210
YP_003846690   4 ISKQAVRRKSVENILASLRIDQLTPGDYVVKGMNACVSGKNTTANVLQEVMRHH 57  Gallionella ferruginea ES-2
ZP_08808811    6 IKGKRNPKRVISSVGASMAMEGLQPSLHAQALGKLYLKDKITGREAIARIKERH 59  Desulfosporosinus sp. OT
YP_004223875   4 LDSQEARRELVIDTMASWALEDMEPTPEMVKDIALYVEGKISTAEIIAKVKRGG 57  Microbacterium testaceum StLB037
ZP_09024041    9 ATTAAERELRVAEAIHSGEMEGLPVTAAGRQDAAEYVAGRIDSDELVARAHARY 62  Propionibacterium sp. 5_U_42AFAA
YP_001709128   7 GAGREERRRRVEDAAHSGEMEGLHLTPSTSEDAGEYVAGRIDATELRERVRARY 60  Clavibacter michiganensis subsp. sepedonicus
ZP_00209681    8 DEERAQRAADAQRIRHSTELEGGRTDDAARAIQDMYVRGEIDGEELIRRTKAYL 61  Magnetospirillum magnetotacticum MS-1
ZP_06912097   54 LSGRAARRAAVASATGSIEAEGLHASEASDRDTEAYVKGDVDADTLVARAIARH 107 Streptomyces pristinaespiralis ATCC 25486
YP_379667     18 KFSDLQTLESTANAIGSNMFEGYKPTPKGIEIIRDYVIGKITLTELIKLAKEKA 71  Chlorobium chlorochromatii CaD3

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