2A7W,3C90,1YVW


Conserved Protein Domain Family
NTP-PPase_HisIE_like

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cd11534: NTP-PPase_HisIE_like 
Click on image for an interactive view with Cn3D
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs
This family includes Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase, HisIE, and its homologs from all three kingdoms of life. E. coli HisIE is encoded by the hisIE gene, which is formed by hisE gene fused to hisl. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity, respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins, all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate.
Statistics
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PSSM-Id: 212141
View PSSM: cd11534
Aligned: 158 rows
Threshold Bit Score: 47.068
Threshold Setting Gi: 21263719
Created: 3-Jan-2012
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
metal binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #  #               #  #                
2A7W_A         6 LKNIADTLEARReaa-pqsSYVASLFHKge--dAILKKVAEEAAETLXASKDkdklHLVREVADLWFHTXVLLTYHGLrP 82  Chromobacterium...
P58834         9 LNRVYDIILDRKeny-denSYVCKLLNHrkgmnKILEKVGEESIETILAVRNedhkEIVSESSDLIFHLLVLLAANNVtL 87  Methanosarcina ...
Q5UZW6         9 IDELFAVIEDRKanl-pedSYTASLFTHekgenAVLEKLGEETTELILAAKDddteELAHESADIVYHLLVLLSMKEMdI 87  Haloarcula mari...
YP_004517066 166 LEELFQVIKERQekr-ppgSYTAKLFNKgl--dKMLEKLGEETTELIIEAKNrdrkEVVEESADVLYHLLVILAEQGItP 242 Desulfotomaculu...
YP_502261      1 MDEIWAVIEERAahpseesYTSKILTHSkg-idKSLEKIGEECTEFIIAVKNgdknRISEEGADLLFHFMLALKRSGVtL 79  Methanospirillu...
ZP_09043745    7 LLDLFEVIRDRVenp-rpnSYVASLVGDpkgidRVLEKVGEETTEYILAVKNgrkeEITYEAADLVFHLMVSLKSAGVeW 85  Methanolinea ta...
ZP_01449091    5 LIRLAQTIENRKngg-dekSYVSELIQSgs--eKCAEKFGEEAVEAIIAAAKrdkkNLTEESADVLFHMLVMLSSCDVdF 81  Rhodobacterales...
YP_004340847   2 LDELYNILVDRKlnprpesYTAKLLYGEkg-inAILEKIGEEATELVIAAKDgkreEIIYETADLLYHILVLLVALDIrL 80  Archaeoglobus v...
B8GKC9         7 IAELWDVIVDRRlhp-vegSYVNSLLSHrkgidKPLEKVGEEATEFILAVKNgesdRIAEEAADLLFHMLVALNAADVdL 85  Candidatus Meth...
YP_003436916   2 LEELQEIVEERKrnptpdsYTAKLLYHEkg-edKVLEKFGEEAVELILACKNkdkeSIVYEAADLLYHFVVLLSKFDVkV 80  Ferroglobus pla...
Feature 1               
2A7W_A        83 EDVVXEL 89  Chromobacterium violaceum
P58834        88 DEIAGEL 94  Methanosarcina acetivorans C2A
Q5UZW6        88 DDLRAEL 94  Haloarcula marismortui ATCC 43049
YP_004517066 243 AEVFAEL 249 Desulfotomaculum kuznetsovii DSM 6115
YP_502261     80 QSVWDEL 86  Methanospirillum hungatei JF-1
ZP_09043745   86 EEILREL 92  Methanolinea tarda NOBI-1
ZP_01449091   82 KSVLKEL 88  Rhodobacterales bacterium HTCC2255
YP_004340847  81 EEIWNEL 87  Archaeoglobus veneficus SNP6
B8GKC9        86 SLVLDEL 92  Candidatus Methanosphaerula palustris E1-9c
YP_003436916  81 EEVYDEL 87  Ferroglobus placidus DSM 10642

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