Conserved Protein Domain Family
Sema_plexin_D1

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cd11247: Sema_plexin_D1 
The Sema domain, a protein interacting module, of Plexin D1
Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Statistics
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PSSM-Id: 200508
Aligned: 6 rows
Threshold Bit Score: 702.761
Created: 6-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y4D7         49 IQRRFPSPTPTNNFALDg------------aAGTVYLAAVNRLYQLSGa-nLSLEAEAAVGPVPDSPLCHAPQLPQASCE 115  human
XP_002187674   45 VQRKFLSPTLTNNFALDg------------pGSRVYLAAVNRLFQLSGg-eLALEAEAAVGPVLDSPLCHAPQLPQASCE 111  zebra finch
NP_991260      33 VQQAFATPGRTNNFALDa------------aSGRIYLAAVNNLYQLNAt--LALEVEMRTGPVLDNPLCHAPQLPQATCE 98   zebrafish
XP_001144599  196 ASGPVRGPDRKGPDSLQgpnpqrepqtlgpgRPWLPATALVQVHSISPlpvQTLACTATSTTYQEFPWAHVGHQTSKTTV 275  chimpanzee
XP_414455      42 VQRKFLSPTPTNNFALDg------------pGSRVYLAAVNRLFQLSGg-eLALQAEAAVGPVLDSPLCHAPQLPQASCE 108  chicken
AAI68545       92 LVSKFHSPQVTNNFALSa------------gEGLLYLAAVNRIYQLNWe--LRPELEDVTGPVPDSPLCHAPQLRETTCD 157  western clawe...
Q9Y4D7        116 Hpr------rLTDNYNKILQLDPg-QGLVVVCGSIYQGFCQLRRRGNISAVAVRFPpaappaepvtVFPSMLNVAANHPN 188  human
XP_002187674  112 Hpr------vLTNNYNKILQPDPe-QGVLVVCGSIYQGLCQLRSMANISAVAVRFPpggs--dsvaVFPSMLNVAANHPN 182  zebra finch
NP_991260      99 Hqk------tLTDNHNKLLALDRa-QDVLLACGSVYQGFCELRRLENVSRLAVQFPqdg-----atVFPSMLNIAANHEN 166  zebrafish
XP_001144599  276 FrdpahpcqpLLYALCVTVWVSQeaSKVRKQFSEVYRGIKGARKPYRVETGLKWAPvig-----dvVIKHLLSVQGAPAS 350  chimpanzee
XP_414455     109 Hpk------vLTNNYNKILQPDPe-QGVLVVCGSIYQGLCQLRSMANISAVAVRFPpggs--dplaVFPSMLNVAANHPN 179  chicken
AAI68545      158 Fpr------tSTPNYNKILLPDPe-QGLLLTCGSIFQGLCELRALRNITLRAVPFPvd-------nAVPSMLNVAANHPN 223  western clawe...
Q9Y4D7        189 ASTVGLVLp----------pAAGAGGSRLLVGATYTGYGSSFFPRNrslEDHRFENTPEIAIRSLdtrg---------dl 249  human
XP_002187674  183 ASTVGLVLr-----------RGGGGGARLLVAATYTGFGSPFFPRNhslEDHRFENTPEIAIRALnarg---------dl 242  zebra finch
NP_991260     167 ASTVGLVF------------RTHGGAPRLLVGATYTGMGTEYFPKNhskEDLRFENTPEIAIRALdtre----------l 224  zebrafish
XP_001144599  351 QPTQAVVAwrwqpgnvgggpRGGPAPLRLLLDRGLSVELPGSFHGPr-pMTGRLRMPPIIQLTEHkgamrglgrpgapse 429  chimpanzee
XP_414455     180 ASTVGLLLhr---------gGGGGGGARLLVAATYTGFGSPFFPRNsslEDHRFENTPEIAIRALnarg---------dl 241  chicken
AAI68545      224 ASTVGLLL------------RGPSGDTKLLVGATYTGYSSQFFPWNqsiADHRFENSPEISIRALnlta----------s 281  western clawe...
Q9Y4D7        250 akLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPsdpppgaqSYAYLALNSEARAGd-KESQARSLLARICLph--- 325  human
XP_002187674  243 akLFTFDINPSDDNILKIKQGDKARHKLSFVRAFLQHgaapparrPYAYLALNTEANAGd-KESPAHSLLARICLgepae 321  zebra finch
NP_991260     225 grLFTYDINPSEDNVFKIKQEVKQKNKLSFVHAFALG--------NYSYIAFNNDANSGl-KESQPNSVLARICLdtda- 294  zebrafish
XP_001144599  430 htGLRVPTPAHESPEHRGQGPAQSRERASFTRRNENHfl-----qPHGDTEMRGTTLGAglEGQGRPSLLGPETRpgrs- 503  chimpanzee
XP_414455     242 akLFTFDINPSDDNIFKIKQGAKARHKLSFVRAFLQRar-----rPYAYLALNSEANAAd-KESPSHSLLARICLgdaae 315  chicken
AAI68545      282 ekLFTFDISPSDDNIFKVKQSFKARHRLGFVRAFQQG--------PFAYLAMNVEPAPAg-KENRPSSVLARICLks--- 349  western clawe...
Q9Y4D7        326 ---gaGGDAKKLTESYIQLGLQCAggagrgdLYSRLVSVFPAR---------ERLFAVFERPQGspaaraaPAALCAFRF 393  human
XP_002187674  322 atlngSGETKKLTESYIQLGLRCGga---adAFTRLVSVFPAR---------ELLFGVFERAGPaggrgrpQSALCVFRF 389  zebra finch
NP_991260     295 --prrAAESRKLTESYAQMGLRCG-------AYTRLLSVSPAElr-----aeTFLFAVFGRAGG-------RAAVCVFRV 353  zebrafish
XP_001144599  504 --pppPEEAEREHFRGQERPLECEg------WQSLEVSPVASTve------kPQHCCLETRSRGa------PAALCAFRF 563  chimpanzee
XP_414455     316 atlngSGEPKKLTESYIQLGLRCGga---adAFTRLVSVFPARaawggpaeeELLFGVFERAGAggg--rpHSALCIFRF 390  chicken
AAI68545      350 ---epRTEPRKLTESYIQLGLRCEg------PGGVLYGRLLSVf-------aESENIFGIFEGKn------EAALCMFPL 407  western clawe...
Q9Y4D7        394 ADVRAAIRAARTACfvepapdvVAVLDSVVQGTGPACErkl--niQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPGL 471  human
XP_002187674  390 AEIEETIRAARNSCfvspaagmVTVLDSVVQGTGPACEkr---niQLQPEQLDCGAAHLQHPLAIVNPVTATPIFTHSGL 466  zebra finch
NP_991260     354 AEVEEMIRQGRRNCshgp-nsdVQVLDSVIQGSGAECEgkgsimlQLQTDQLNCGAAHLQHPLALRRPLRARPLYEAQGL 432  zebrafish
XP_001144599  564 APLRAPIRAARTACfvepapdvVAVLLSVVQGTGPACErkl--niQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPGL 641  chimpanzee
XP_414455     391 AEIEETIRAARNSCfvspaagmVTVLDSVVQGTGPACEkr---niQLQPEQLDCGAAHLQHPLAIVNPITATPVFTYNGL 467  chicken
AAI68545      408 RSVAQEIRGARRGCfesqdageVTVLDSVVQGTGPSCErrn-akvKLQEEQLDCGAAHLQHPLAITRPLPAVPIYKEKGL 486  western clawe...
Q9Y4D7        472 TSVAVASVnNYTAVFLGTVNGRLLKINLNESMQVVsrr--vvtVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVA 547  human
XP_002187674  467 TAVAVASVnNYTVVFLGTASGGLLKINLDSTMKVIsrr--silVAYGEPVHPIMQFDPSDSTYLYLMTSYQMTRVKVA 542  zebra finch
NP_991260     433 SSVAVDSA-HNHTLMFLGSRGRLHKVSLHSNFSVSqqw--slrLPANEPVHHIMTFDPSDRTYLYVMTSHHLLRVRVS 507  zebrafish
XP_001144599  642 TSVAVASVnNYTAVFLGTVNGRLLKINLNESMQVVsrr--vvtVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVA 717  chimpanzee
XP_414455     468 TAVAVASInNYTVVFLGTASGGLLKINLDTAMRVVsrr--sisVAYGEPVHPVMQFDPSDPTYLYLMTSYQMTRVKVA 543  chicken
AAI68545      487 TSVAVANVsGYMVVFLGNVSGHLIKINLDADMKIInksmqyleIASGQPVHHVMEFDPMDPTYLFVMTSHQMTRVKVA 564  western clawed ...
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