2WO3,3CZU,1SHX


Conserved Protein Domain Family
Ephrin-A_Ectodomain

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cd10425: Ephrin-A_Ectodomain 
Click on image for an interactive view with Cn3D
Ectodomain of Ephrin A
Ephrins and their receptors EphR play an important role in cell communication in normal physiology, as well as in disease pathogenesis. Binding of the ephrin (Eph) ligand to EphR requires cell-cell contact, since both molecules are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling, depending on Eph kinase activity) and ephrin-expressing cells (reverse signaling). Eph signaling controls cell morphology, adhesion, migration and invasion. Ephrins can be subdivided into 2 groups, A and B, depending on their respective receptors EphA or EphB. The nine human EphA receptors bind to five GPI-linked ephrin-A ligands. Interactions are promiscuous within each class, and some Eph receptors can also bind to ephrins of the other class. All ephrin As contain a highly conserved receptor binding ectodomain described by this model. Although ephrin As do not have a cytoplasmic tail (in contrast to ephrin Bs), they are still capable of downstream activation of Src family kinases and phosphoinositide-3-kinases, most likely involving coreceptors such as neurotrophin receptors.
Statistics
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PSSM-Id: 259896
View PSSM: cd10425
Aligned: 17 rows
Threshold Bit Score: 169.799
Threshold Setting Gi: 118344250
Created: 13-Jun-2011
Updated: 20-Aug-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
receptor
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #                                              
2WO3_B         6 DRYAVYWNRSNPRFHAgagddgGGYTVEVSINDYLDIYCPHYGaplp-------paerMEHYVLYMVNGEGHASCDhr-q 77
3CZU_B        30 DRHTVFWNSSNPKFRN------EDYTIHVQLNDYVDIICPHYEdhsv-------adaaMEQYILYLVEHEEYQLCQpq-s 95
gi 1706671    31 NRHAVYWNSSNQHLRR------EGYTVQVNVNDYLDIYCPHYNssgvgpgagpgpgggAEQYVLYMVSRNGYRTCNas-- 102
gi 6166142    26 LRHPIYWNSSNPRLLR------GDAVVELGFNDYLDIFCPHYEspgp--------pegPETFALYMVDWSGYEACTaega 91
gi 82071050   21 ERHSVYWNSTNANFLW------DDYTVDVRINDYLDIICPHYAhgei-------asqeAERYVLYMVELEDYENCKph-s 86
gi 1706667    29 ERHIVFWNSSNYRFMQ------EDYTVQVQLNDYLDIVCPYYEegsv-------aghtVERYTLFLVDYEEYETCKpk-s 94
gi 148234293  21 NRHSVYWNSSNYHLRR------DGYTVQVDVNDYLDIYCPHYNesvv--------ehkMEQYILYMVSYEGYRTCNis-- 84
gi 18858589   24 ARHAVHWNSSNILLRK------EGYTLQVNVNDYLDIYCPHYNssq---------rgiAEQYVLYMVSYRGYRTCDpq-- 86
gi 326674907  28 KRHVVYWNSTNTRLTG------DDYSVQVNLSDYLDILCPHYPgdhp-------sgasVETLALYLVAESQFRGCVdt-k 93
gi 74136745   23 TRHVVFWDRSINSSLT------TELRLQVQINEWMDILCPKPArnde-------krgeELYIDVFNVTAAQYHRCNtq-- 87
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1          #####           ##      ###### ##                                    
2WO3_B        78 rGFKRWECNRPAApggPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPn-aVDRPC-----LRLKVYVR 142
3CZU_B        96 kDQVRWQCNRPSAkhgPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHq--HEDRC-----LRLKVTVS 159
gi 1706671   103 qGFKRWECNRPHAphsPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHn--LHWKC-----LRMKVFVC 166
gi 6166142    92 nAFQRWNCSMPFApfsPVRFSEKIQRYTPFPLGFEFLPGETYYYISVPTPe--SPGRC-----LRLQVSVC 155
gi 82071050   87 fDQLRWECSRPFAphaPEKFSEKFQRFTPFTLGKEFRQGESYYYISKPLHh--HGQEC-----LRLKVDVV 150
gi 1706667    95 kDQVRWECNKPFAphgPEKFCEKFQKFTPFTLGTEFREGRTYYYISKPIHy--HGETC-----MRLRVHVS 158
gi 148234293  85 qGFKRWECNRPHVphsPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHn--HRRSC-----LKMKVFVC 148
gi 18858589   87 lGFKRWECNRPHAphaPIKFSEKFQRYSAFSLGYEFHVGQEYYYISTPTHh--HGRSC-----LRLRVYVC 150
gi 326674907  94 eAIKRWECNQPFApfgPVRFSEKIQRFTPFSLGFEFLPGHHYYYSCNCGSlfaVRRQQldhldKKPQKHHH 164
gi 74136745   88 kIQRVLRCSDPKR---EIKLTTKFQERSPSPLGFVFRPGQSYYYISKPSKg--GTRGCst-dtLRLVVEVE 152

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