3HHR


Conserved Protein Domain Family
somatotropin_like

?
cd10285: somatotropin_like 
Click on image for an interactive view with Cn3D
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.
Statistics
?
PSSM-Id: 198435
View PSSM: cd10285
Aligned: 11 rows
Threshold Bit Score: 191.122
Threshold Setting Gi: 296201795
Created: 16-May-2011
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
receptor
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding interface [polypeptide binding site]
Evidence:
  • Structure:3HHR: Human growth hormone binds to the extracellular domain of its receptor, contacts at 4 A
    View structure with Cn3D
  • Citation:PMID 1549776

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #  ## #  ##  #               ##  ## #            ### #  ##                   
3HHR_A         9 LFDNAMLRAHRLHQLAFDTYQEFEEAYIpKEQKYSFLQNPqtSLCFSESIPTPSN-REETQQKSNLELLRISLLLIQSWL 87
gi 267016     26 LFSIAVSRVQHLHLLAQRLFSDFESSLQtEEQRQLNKIFLq-DFCNSDYIISPID-KHETQRSSVLKLLSISYRLVESWE 103
gi 134707     35 LFTNAVLRAQHLHLLAAETYKEFERTYIpEDQRYTNKNSQa-AFCYSETIPAPTG-KDDAQQKSDMELLRFSLVLIQSWL 112
gi 134691      9 LFTNAVLRAQYLHQLAADIYKDFERTYMpNEQRHSSKNSPs-AFCYSETIPAPTG-KDEAQQRSDVELLQFSLALIQSWI 86
gi 134696     28 LFTSAVNRAQHLHTLAAEIYKEFERSIPpEAHRQLSKTSPl-AGCYSDSIPTPTG-KDETQEKSDGYLLRISSALIQSWV 105
gi 223953342  35 LYDYAMIRAYRLNQLAFDIYQKFEEARSpKEQKDFLQHKArtSLCFSASVPTPTN-RKETLQQSNVELLRNSLLLIQLWF 113
gi 222092501  25 RFSIAVSKVQHLHLLAQKYFSDFENSLQtEDQRQFNKFHQ--DFCNPDNIIIPDN-KHETQRSSVLNLLLISKRLVDSWE 101
gi 296201795   1 MGLHVPVDIGGRMVGDTESYMELRDPPPfPPGSSSLVVLEgaGACLENSPQPSALpADDESGVLNLELLRISLLLSQLWL 80
gi 730764     34 LFTNAVIRAQHLHQMVADTYRDYERTYIpEDQRFSNKHSYs-VYCYSETIPAPTD-KDNTHQKSDIDLLRFSLTLLQSWM 111
gi 17368060   32 LLSNAVQRANYLHNLAGDRYRDFEQNYIsDEQRHSIKNSPa-AYCYSESSPAPTG-KEDARQKSDMDLLRFSLSLIQAWI 109
gi 134715     35 LFANAVLRAQHLHQLAADTYKEFERAYIpEGQRYSIQNAQa-AFCFSETIPAPTG-KDEAQQRSDVELLRFSLLLIQSWL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #  ##  #                                            
3HHR_A        88 EPVQFLRsvfanslvygASDSNVYDLLKDLEEGIQTLMGRLEDg------------------------------------ 131
gi 267016    104 FPSRSLAgg-------sAPRNQISPKLSELKTGIHLLIRANEDgae---------------------------------- 142
gi 134707    113 TPMQYLSkvftn-nlvfGTSDRVFEKLKDLEEGIQALMRELEDr------------------------------------ 155
gi 134691     87 SPLQSLSrvftn-slvfLTSDRVFEKLKDLEEGIVALMRDLGEg------------------------------------ 129
gi 134696    106 YPLKTLSdafsn-slmfGTSDGIFDKLEDLNKGINELMKVVGDg------------------------------------ 148
gi 223953342 114 KPVQVFSsvfansqlhgVSHSFIYEYLKDLEEVIQTLIGVRVApevpnpgaplasragrkkhccslfssqaliqetsays 193
gi 222092501 102 FSIHFITwn-------lFPRNQVLHRLSDLKKGIQMLIEASDGae----------------------------------- 139
gi 296201795  81 KPVKFLNsvftnsqlhsISNTDIYEYLKDLEEGIQTLTGRLEDg------------------------------------ 124
gi 730764    112 TPIQIVNrvfgn-nqvfGNIDRVYDRLRDLDEGLHILIRELDDg------------------------------------ 154
gi 17368060  110 SPLQILGr--------pFGSPDAYDKLLDLEKGLQVLMRELEDg------------------------------------ 145
gi 134715    113 GPVQFLSrvftn-slvfGTSDRVYEKLKDLEEGIQALMRELEDg------------------------------------ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##  ## ##  ##  #    
3HHR_A       132 -------------------------sPRTGQIFKQTYSKFDtnshndDALLKNYGLLYCFRKDMDKVETFLRIVQCRSv- 185
gi 267016    143 ------------------------lfPDSSALQLAPYGDYYhspgtdESLRRTYELLACFKKDMHKVETYLTVAKCRLsp 198
gi 134707    156 -------------------------sPRGPQLLRPTYDRFDihlrseDALLKNYGLLSCFKKDLHKVETYLKVMKCRRfg 210
gi 134691    130 -------------------------gFGSSTLLKLTYDKFDvnlrndDALFKNYGLLSCFKKDMHKVETYLKVMKCRRfv 184
gi 134696    149 -------------------------gIYIEDVRNLRYENFDvhlrndAGLMKNYGLLACFKKDMHKVETYLKVTKCRRfv 203
gi 223953342 194 sfplvnppglslhhgalekreekervREGGNSVQALASPSLpslcrgWKMAAPGLGTSSGRPTASLTQTCTRMTHCSRtt 273
gi 222092501 140 -------------------------mSDSITLPVTPFGNFYenlggnESQKRNYELLACFKKDMHKVETYLTVAKCRLsp 194
gi 296201795 125 -------------------------sPRTGEIFRQTYSKFD------RNSHNDDTLLHCFRKDIDKVEKFLCIVQCHSv- 172
gi 730764    155 -------------------------nVRNYGVLTFTYDKFDvnlrseEGRAKNYGLLSCFKKDMHKVETYLKVMKCRRfv 209
gi 17368060  146 -------------------------sSRGLSLLKHTYDKFSanqfseEATLKNYSLLACFKKDMHKVETYLRVMKCRRfp 200
gi 134715    156 -------------------------sPRAGQILKQTYDKFDtnlrsdDALLKNYGLLSCFKKDLHKAETYLRVMKCRRfv 210
                        250
                 ....*....|....*..
Feature 1                        #
3HHR_A       186 -------------eGSC 189
gi 267016    199 -------------eANC 202
gi 134707    211 -------------eSNC 214
gi 134691    185 -------------eSNC 188
gi 134696    204 -------------eSNC 207
gi 223953342 274 rcciasgetwtrsrHSC 290
gi 222092501 195 -------------eANC 198
gi 296201795 173 -------------eGSC 176
gi 730764    210 -------------eSNC 213
gi 17368060  201 -------------eSNC 204
gi 134715    211 -------------eSSC 214

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap