Conserved Protein Domain Family
Cas3_I

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cd09639: Cas3_I 
CRISPR/Cas system-associated protein Cas3
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Statistics
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PSSM-Id: 187770
View PSSM: cd09639
Aligned: 7 rows
Threshold Bit Score: 382.933
Threshold Setting Gi: 14521227
Created: 4-Feb-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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PubMed ReferencesClick to see Conserved Features Help

cd09639 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd09639 is a member of the superfamily cl21455.
cd09639:Cas3_I11499458145212271459106615605877250649334541605156685521149945814521227145910661560587725064933454160515668552
cd09639 Sequence Cluster
cd09639 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506493  309 LTVIEAPTGSGKTETALAYAWklid---qqiaDSVIFALPTQATANAMLTRMEAsashlfsspnlilahgnsrfnhlfqs 385
gi 34541605 255 LLLVRAPTGAGKTDAALLWAShqik---hrkaDRLIIAMPTRFTTNALALSVSStlsstgly---------------hss 316
gi 15668552 221 FVMLFAPCGRGKTEGALLWALnalk---nfkrNKIILAMPTQVTSNAMYDRLVKifgeenvglf-----------hgksf 286
gi 14591066 246 DVILYAPTGYGKTEAALLWANknahrtkkgisSRIFYILPYKASINAMHRRLLEmfkdpglv---------------gll 310
gi 11499458  40 IFVIEAPTGYGKSTISATIAAysl-----qeeLKSIIAFPLRTLLEDQYNKFKGlfgn---------------------- 92
gi 15605877 239 CLVVVAPTGYGKTEAGFIFLK-----------DKGFFTLPFRVSANGIYERARAvfgenvgllh-----------sssli 296
gi 14521227  40 FLVIQAPTGYGKTTLSLSLALhslkd--sslfDRVIHVLPMRSIIEDIDRTAKEafg----------------------- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506493  386 iksrAITEQGQEEAWVQCCQWLSQsnkkvFLGQIGVCTIDQVLISVLP-----VKHRFIRGLGIGRSVLIVDEVHAYDTY 460
gi 34541605 317 awtqNFSSKIDNGEIALEQARYYHnqarlLQTPITVCTIDHLLSSLTLc----DEEHQTITFALANACLVIDEADFYDQF 392
gi 15668552 287 iklrDSKEIEDEDDLEEIRDENFKgn--vFFKPITITTIDHVIYSFVHg----FSQADFALGNIQNSVIIFDEVHYYEKY 360
gi 14591066 311 hsssGIYLYSSSLEYKRLLSLYGK-----IYSPIKITTPFQIMKAFFG-----VGFFEITLVELINSLLIFDEIHAYESN 380
gi 11499458  93 klgkRYMHNPDSPYLIKPVTLTTIdtlalTLFGIPPEDLDKAVKYWDGtssgsLGHYLFSQASVALSNIVLDEVHLLADS 172
gi 15605877 297 elmkKEEDELDTNTFEGIWKNYQHsk--sFAYPLTVCTPDQIMPFVFK-----FSGYEKYLALLSYSRIVIDELQVYAPY 369
gi 14521227  95 --fsRTKMMGSSEEFLHLFPLNITtvdtfTWDILKLNTKKITQVERGRe----FGYDYLTQASILTSLVIFDEAHFILEE 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506493  461 MNGL--LEAVLKAQA-DVGGSVILLSATLPmkqkqKLLDTYGLHTDPVeNNSAYPlinwrgvngaqrfdllahpeqlppr 537
gi 34541605 393 TQAN--ILVLLEVLK-YWKVPILLMSASLP-----DNIVQEYRKIGYDiKHILEDtsdier------------------- 445
gi 15668552 361 TLEH--LLTLFDILR-RMDIPHLLMSGTLP-----NFLMNNLEGYELVvDEEGLNykpfklkcs---------------- 416
gi 14591066 381 ILGI--ILAMLELLK-EKRAKALVMTATFP-----KFLEELIKSILNPkELKTPPeeadk-------------------- 432
gi 11499458 173 TKSLn-FLFALMHAAiDNDQKLVLMSATIPea-lkKRIKEFNPDVCMVeFNESFDrkfveerrk---------------- 234
gi 15605877 370 TMAF--IVKALEVIK-DFGSKFMVMTATFP-----EFLRRFFEKMEIP-FKEFPElkprh-------------------- 420
gi 14521227 169 PRMKtaFLAVLRFLM-ENNVPIIIMTATLSrg-yfELFKKYAQNNGYYfEPEPLVpdend-------------------- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506493  538 fsiqpepicLADMLPDLTMLEr-mIAAANAGAQVCLICNLVDVAQVCYQRLkelnnt----qvdidLFHARFTLNDRREK 612
gi 34541605 446 ---arfsliEKRDVSEISQMQd-lLQLCLDRGSAIIFANTVDRAQAYYQWFlengh-----eeeviLYHSRYTETDKIEK 516
gi 15668552 417 -enhliwkeDDEWKVNENIINe-iIENYKKGLSQAIILNTVERAREFYKAVrdkv--------paiLYHSQFAYKDRVKK 486
gi 14591066 433 ----ftrhrVNVIDGDIRTLD---SEEFPGPRPILIACNTVNTSIEVYSKLkesg-------anvmLIHGRFTYGDREDK 498
gi 11499458 235 -kkyrinliALASVEKFGSLErilLEGSKKFSKITVVFNTIGDAVYFYNNIkekip-----efkklLLHSRFSEMDREKK 308
gi 15605877 421 -----nvklLEDTLGSESSINl--IRSLSEEGKVLVIVNTVRKAQELSLLLna------------pVLHSRFLQKHRAKK 481
gi 14521227 227 ----pfikrESKKNFEIQFKTgnpLDFIDSAKRNAIIVNSVKRAVEIFDQAkedapklgfeeeeimLIHGRMKPSHKARL 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506493  613 e-NRVISNFGKngkr--nvgrILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRhhRKYRpagfeIPVATILLPD 689
gi 34541605 517 e-AQLLLRLGRsawdndrangVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRfsRKIG-----DLYIIRPMRE 590
gi 15668552 487 edEIFTLEEMRksqn---kpyVIVATQVIEISLDMSVDVMYSELSPPDALGQRAGRLHRkgKDWRen--gKEYKLKIFLP 561
gi 14591066 499 e-KMLMNSLSDf--------dFVVATQVIEVSLDIDFGSIITEPAPLDALIQRFGRVNRrgFGKPr----DVYVLTKGSE 565
gi 11499458 309 --AELLAEMKKse------kfVIVTTQVIEAGVDISSNLFITEIAPASSLIQRLGRFLRygEREG-----EVYIWYEVDD 375
gi 15605877 482 e-EEIKEFFSSge------kgVWVTTQLAEVSLDLDADFLVTELSTIDSLIQRMGRCNRkgIKDIen--pNVYVFTQEPS 552
gi 14521227 303 --IEKLREWKNke------sfLIIGTQAVEAGVDFSVDVMITDAAPINSLIQRFGRVARydEKNA-----EIIIIEDAPV 369
                       410       420       430
                ....*....|....*....|....*....|....
gi 2506493  690 Gegygr-------hehiYSNVRVMWRTQQHIEEL 716
gi 34541605 591 GnlfpapyyqnvgpsqkLEPNDALIQTDELLEKG 624
gi 15668552 562 Ykh-------------lPYSKELIEKTINHIKFY 582
gi 14591066 566 Ddk------------nvYRPYDVVEETVKILREI 587
gi 11499458 376 Rgelarw----kddrykVYDYSLTALTLEKLAEM 405
gi 15605877 553 Gkg-------------sVYPKELLELTRKALTEG 573
gi 14521227 370 H----------------PYDGKKVERTIALMKES 387
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