1JZS


Conserved Protein Domain Family
Anticodon_Ia_Ile_ABEc

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cd07961: Anticodon_Ia_Ile_ABEc 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153415
View PSSM: cd07961
Aligned: 129 rows
Threshold Bit Score: 154.246
Threshold Setting Gi: 19074910
Created: 28-Sep-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
anticodontRNA binding
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Comment:by similarity to other members of this family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #  #                                                          
1JZS_A        630 FGPNLVRETVRdYFLTLWNVYSFFVTYANLdrpdlknp-----------pppekrpEMDRWLLARMQDLIQRVTEALEAy 698
gi 224822791  644 FSWEGMQTMEN-HLRTLWNVFRFPLPYMRLdefdpqatt--------vedvqadleLIDEWVLARLQSTKDEMTAHFDEr 714
gi 110668577  645 FEWDGLGEMQS-TLNIFWNVFRFPLPYMDLdgydpata----------dlsegsmnIVDEWVLSRLQSVKATTRAAWEEy 713
gi 71394074   617 FDWNTLRENRK-FFVVLSNTYRFFQLYGDKieleev---------------kndlkPEDMWILSKINSLVARVTQLNKEf 680
gi 124028274  643 FDPDEVRRYQG-YLNILWNTVKFADTYMELdkwkpkn------------paearlaVEDRWILYRLWQALEKASEAIESd 709
gi 74568871   645 FSWDETENMQR-DLNILWNVFRFPRPYMALddfdanvpaafggddagvgiadadleTVDEWLLSRLQHVKADATAHWEDf 723
gi 74564220   643 FDPDEVKYVIG-DLNILWNVVKFADTYMSLdgfdaekyp--------lsqwlekglEEDKWILSELNIMISEFTNFVKNf 713
gi 156937807  658 FDPEDIKLAKR-TLDILWNSVKFAKSYMELdkwslekl----------eeglkslePEDSWVLWKLNEYSKRVAEELERs 726
gi 170290812  637 FSWKGMEEVSR-KLNIIWNVYVFATTYIGDrdikdld-------------psdvrdPINKWLISRLNTTMKNFREAMEEy 702
gi 159041762  647 VNPDEFSGIRN-ILTVLWNSVRFADMYMRLdnydprghs--------inevlpkakSEDKWMLSRYFSRLSRITQYLDEf 717
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1JZS_A        699 DPTTSARALRDFVVEDLsQWYVRRNRRRFwknedaldrEAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRsvrleak 778
gi 224822791  715 RQDKALNALIDFVVEDVsRFYVQAVRERMweeedsaskEAAYATIYRVLRETVALLAPYAPFISEEIYGTLTGda---eh 791
gi 110668577  714 EIDTAVNTILEFITDDVsRFYIKAIRERMwadedsaskRGAYATLSTVLDETIRLLAPIAPYLTEQMYQHLNGs-----e 788
gi 71394074   681 RHNRALKEIEYFVVNDLsRTYVKLIRDRTwptyngkdkKAAQAVLYYVLDKVDRLLAPAMPFFTERMYLTVLGgg----k 756
gi 124028274  710 NMHQAVQALVDLVVEQVsHRYIPLIRPRVweeemteskDAAYATLYYVLRAVLAAMAPIAPFVTEYLYQAFVRkyepdap 789
gi 74568871   724 EQHRALDAVLEFVVEDLsRYYVQVVRERMweddasaskTAAYATMQRVLLEVVALLAPYAPFVTEELYSHLTGdr---gy 800
gi 74564220   714 EFHKAAALWREFVVETLsHRYIRLLRRRVwseepspdkYAAYAVLHDVLKKVLILGSILVPFITEYLWQAYVRkyeknap 793
gi 156937807  727 AIHRAAQALQEFIVEVLsHKYITLVRPRVweeeetpskLAAYSALFLALDAAIRMSAPFVPFLAEYLYQRFQRalg-fee 805
gi 170290812  703 NLHVASNEIINFLVEDVsHLYLRVSRKKIrskd-eatsSEWISVLYYVLRNAIPYLSVVTPFLAEKIYLDAFMmng--dp 779
gi 159041762  718 RIHEAAREWISLIVDDVsHGYIRLIRRRVwvegsdddkLVVYTVLYNVLKGAIVIGSVFTPFITEYLYKAFVRda----a 793
                         170       180       190
                  ....*....|....*....|....*....|....*
Feature 1                                            
1JZS_A        779 ESVHLADWPEAdpalaDEALVAQMRAVLKVVDLAR 813
gi 224822791  792 DTVHMCDWPTVdetfvDEQLEEDVAFLRAIEEAGA 826
gi 110668577  789 TTVHALSYPSVdpewqNETLESEMAVLRDVEEAAA 823
gi 71394074   757 ESIHLEDWPKInenliDKDLEESMEIIHEITDAAL 791
gi 124028274  790 ESIHLNQWPTVpqellDEKAYKAVEEAFAAAEKIL 824
gi 74568871   801 DTVHMADWPTVeeslrAPALEADVAVLRAAEEAGS 835
gi 74564220   794 ESVHLAQYPAAgs--yDKELIYAYRELFAVFSALA 826
gi 156937807  806 ESVHMLQWPEEns-lyDPEEAKAVEELLEAAEKVL 839
gi 170290812  780 ESVNFLTLPEPnllmiDEELESLMDIVRGIISSSG 814
gi 159041762  794 DSVHLAPMPEIrrdliNERLEKAYDAIFEAFSLTA 828

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