3DO7,1IMH,1BVO,1OWR,1GJI,3DO7,1VKX


Conserved Protein Domain Family
RHD-n

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cd07827: RHD-n 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD)
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).
Statistics
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PSSM-Id: 143640
View PSSM: cd07827
Aligned: 14 rows
Threshold Bit Score: 147.9
Threshold Setting Gi: 46015057
Created: 29-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1BVO: Anopheles gambiae dorsal homolog Gambif1 binds DNA, contacts at 4A
    View structure with Cn3D
  • Structure:1IMH: Human TonEBP dimer binds DNA, only a single TonEBP monomer and DNA strands are shown, contacts at 4A
    View structure with Cn3D
  • Structure:3DO7: Human NF-kappa B2 (p52)/RelB heterodimer binds DNA, contacts at 4A
    View structure with Cn3D
  • Structure:1VKX: Mus musculus NF-kappa B1 (p50)/RelA (p65) heterodimer binds DNA, contacts at 4A
    View structure with Cn3D
  • Citation:PMID 9450761

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # ## ##   ####                                                    
3DO7_B         2 PYLVIVEQPKQRgFRFRYGCEg--PSHGGLPGAssekgRKTYPTVKICNYEg--PAKIEVDLVTHSdp-pRAHA-HSLVG 75
1IMH_C        17 KELKIVVQPETQ-HRARYLTE---GSRGSVKDRt----QQGFPTVKLEGHNe--PVVLQVFVGNDSgr-vKPHGfYQACR 85
1BVO_A         1 PYVEITEQPHPKaLRFRYECEg--RSAGSIPGVnttaeQKTFPSIQVHGYRg--RAVVVVSCVTKEgpehKPHP-HNLVG 75
3DO7_A        16 PYLVITEQPKQRgMRFRYECEg--RSAGSILGEssteaSKTQPAIELRDCGglrEVEVTACLVWKDwp-hRVHP-HSLVG 91
gi 48428477  150 PQLRIVEQPVEK-FRFRYKSEm-hGTHGSLNGAnskrtPKTFPEVTLCNYDg--PAVIRCSLFQTNl--dSPHS-HQLVV 222
gi 170032413 337 PHLVITVQPQSRgLRFRYQCEnrgSTAGSILGVgstaqRRIYPTVEIRNHQg--PAKIVITCVTSDdp-pRLHP-HRLVG 412
gi 170051861  52 PQIVITEQPHPKlHRFRYQSEqrgSTAGSILGVrasgdRPTYPTIEIQGYHg--PAKIVISCLSTDdp-pRLHP-YRLIG 127
gi 72016431   54 PYCEITEQPKQRdHRFRYPVEg--RQAGSIAGEkstsdLPSYPTIKVANLSg--RAKVVVSLVTKNdp-pLPHP-HRLVG 127
gi 196475501  66 PFLEIVEQPKQRgQRFRYLCEg--RSAGSLPGEhsthdHKTFPSARLRNYNk--EAMVVVSLVTKNep-yMPHP-HSLVG 139
gi 219425527   1 PVIEIIEQPKARsLRFRYECEg--RSAGSILGEnsspeNRTYPTIRLLNCSg--PAMILVSLVTKDdp-pKPHP-HSLVG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   # ##                                 
3DO7_B        76 K--------QCSe---lGICAVSVGpk----dMTAQFNNLGVLHVTKKNMMGtmiqklqrqrlrsrpqglte-aeqrele 139
1IMH_C        86 VtgrnttpcKEVdiegtTVIEVGLDps---nnMTLAVDCVGILKLRNADVEArigiag---------------------- 140
1BVO_A        76 Ke-------GCKk----GVCTVEINst----tMSYTFNNLGIQCVKKKDVEEalrlrqeirvdpfr------------tg 128
3DO7_A        92 K--------DCTd----GVCRVRLRph---vsPRHSFNNLGIQCVRKKEIEAaierkiqlgidpy--------------n 142
gi 48428477  223 Rk-------DDR-----DVCDPHDLhvskergYVAQFINMGIIHTAKKYIFEelckkkqdrlvfqmnrrelshkqlqelh 290
gi 170032413 413 Hk-------DCSe----GLCEMLVEptp-tpvMAHSIKNLGVQCIRRKDVDAelrkkemryanpf--------------- 465
gi 170051861 128 Rp-------ECRh----GLCVLRVGpe---sgMTYSVNNLAVQSVLKKDVAKeleqrqqcypnpf--------------- 178
gi 72016431  128 D--------GCRd----GVCTRMIDpq----rPEVVFHKIGVQRTMNKEVENsleerkragvklsmv-----------vn 180
gi 196475501 140 K--------GCAk----GICTMKVStd---tkMEASFQNLGIQCVRKKDIAEalqkrkelgidpygm-----------fq 193
gi 219425527  75 K--------GCIh----GICKINSSp------PPVSFPNLGIQCVKRKEITQalaqrirlgidpfh------------ty 124
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                                                        #
3DO7_B       140 qeakelkkvmdlSIVRLRFSAFLrdsd---gsfsLPLkPVISQPIHDSK 185
1IMH_C       141 -------skkksTRARLVFRVNImrkd----gstLTL-QTPSSPILCTQ 177
1BVO_A       129 fghakepgsidlNAVRLCFQVFLegqqr--grftEPLtPVVSDIIYDKK 175
3DO7_A       143 agslknhqevdmNVVRICFQASYrdqq----ghlHRMdPILSEPVYDKK 187
gi 48428477  291 qetereakdmnlNQVRLCFEAFKiedn---gawvPLApPVYSNAINNRK 336
gi 170032413 466 nvptgnsstinlNEIRLCFQLHIesyp---gqfiPVSyPVLSTIIYDKK 511
gi 170051861 179 kvpvgdastidlKKVRLCFELYLetap---gqfrVVHpPVLTDTVYDRK 224
gi 72016431  181 kgktgkkhnyemKAVRLFFEVYIeties-sgvfdKYLtPVTSTAVYDKK 228
gi 196475501 194 kgqkfsvedfelNVVRLCFQAFLrdpkdpngrfiIPVsPIVSHPIHDKK 242
gi 219425527 125 srhkgkmdevdlNTVRLCFQAFLphpqt--gqctVPVpPRVSMPIHDKK 171

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