Conserved Protein Domain Family

cd07765: KRAB_A-box 
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KRAB (Kruppel-associated box) domain -A box.
The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
PSSM-Id: 143639
View PSSM: cd07765
Aligned: 113 rows
Threshold Bit Score: 43.307
Threshold Setting Gi: 55976755
Created: 30-Sep-2008
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1V65_A         8 VTYDDVHMNFt-----eEEWDLLd----------sSQKRLYEEVMLETYq--NLTDI 47   house mouse
AAI20582     129 VTTEEVAGCFp------EQQEGSpe---------dWQKELCKRVAKERHe--VLGSL 168  house mouse
Q63HK3       227 EPVKDVHVARgfs--yrKSVHQIp-----------AQRDLYRDFRKENVg--NVVSL 268  human
Q9UJW8        72 VNFKIVTVDFt-----rEEQGTWn----------pAQRTLDRDVILENHr--DLVSW 111  human
XP_001517541 305 RTFEDLAVRFs-----qERWEQPd----------pAQRELYRDIGRENYg--NEGAL 344  platypus
XP_001499841 552 VKFCDLAVLLpcvsrelQEMVTLvdssggvglldpSQRRLCREVMLEKIs--RLVSQ 606  horse
Q96LX8        14 ILFEDLAVYFs-----qEECVTLh----------pAQRSLSKDGTKESLedaALMGE 55   human
XP_001507601  17 VLFEDLAVYFs-----qEECVNLq----------pIQRDSCKDARWEMYk--EMFPL 56   platypus
Q9Y2L8       218 EEVADVAVSFi-----lEEWGHLd----------qSQKSLYRDDRKENYg--SITSM 257  human
EAW72465     232 VTIKNLAVDF-------RQQLHP------------AQKNFCKNGIWENNs--DLGSA 267  human
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