Conserved Protein Domain Family
MPP_YvnB

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cd07399: MPP_YvnB 
Bacillus subtilis YvnB and related proteins, metallophosphatase domain
YvnB (BSU35040) is an uncharacterized Bacillus subtilis protein with a metallophosphatase domain. This family includes bacterial and eukaryotic proteins similar to YvnB. YvnB belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Statistics
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PSSM-Id: 277344
View PSSM: cd07399
Aligned: 5 rows
Threshold Bit Score: 295.171
Threshold Setting Gi: 29348324
Created: 22-Apr-2009
Updated: 27-Mar-2015
Structure
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Aligned Rows:
 
putative activeputative metal
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # #                                       #                              
gi 2618853    920 YTFVWMSDTQYYae---syPHIFDKQTEWIKDNqk---qlNIKYVFHTGDIVDdsadirqWKNADRSMSVLdksGIPYGV 993
gi 19554254  1083 FTLAWESDTQYYne---efHEHQTNIHDYVLAEre---nkNIQFMFHTGDVVDdwdqpaqWATANPEYQRLddaGLPYSV 1156
gi 164658656   50 FTVIVMPDTQYLfdenrihPVPMEASFEYIVSPnrseadkNIVFVSHLGDVAQngl-akeYAAVTKLFDYMdesGVEYSV 128
gi 21225892    60 FALAVLPDTQYLfdadsadPAPLRATFRHLVTEra---aaNIAFMTHLGDVTEhgt-eaeIELAADTFRVLh-gRVPYSV 134
gi 29348324    27 VRLVLLPDIQTYsr---lyPDILKSQTQWAIDHa-----dSIDFVLQQGDMTDhnv-dkeWEVAAAALNTMd-nQVPYAF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##                                                                           
gi 2618853    994 LAGNHDvghkdgsyrafgkyfgsdrfdkkf----hyggsyknnrghydlissngndyIMLYMGWGITDEDIAWMnqVLKK 1069
gi 19554254  1157 LAGNHDvghtsndytefsrhfgeqryvdnp----wygesyqdnrghydlfsaggidfINVAMGWGPDDEEIAWMneVLAK 1232
gi 164658656  129 LAGNHDidsstddqrgptpyldvfnpkrfsk-irswrgsssdgynnyhvfhaggrewLVLALDWRMSSGTFKWAsdVLRK 207
gi 21225892   135 LAGNHDirsstddqrgdsaylsafgpdryrs-mptfggaspdgynsyhvlraggrqwLVLALDWRVSEQGLAWAqgVLDR 213
gi 29348324    97 VMGNHDlgknsnkrdselfnryfpydkysktrnfggafeegkmdnvwytfkaaglkwLILCLEFGPRTSVLDWAgeIVKK 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                                                       #             
gi 2618853   1070 HPDRMAILAFHEYLlvsgnrsp----------------------igekifkeIVKPNPNVVMVLSGHYHsamrktdeldd 1127
gi 19554254  1233 HPERVAILNLHEFMlttgglgp----------------------ipqrildeVAATNPNVSMIMSGHYHdafqrtdsfdd 1290
gi 164658656  208 HADLPTILTTHELVtadsgktefs-------------------eygervwneLVRDNDQIFLTLNGHFWppgrttr---- 264
gi 21225892   214 HPALPAVLTTHDIAwsgddgearl------------------sdhgqrlwdgLIKGNDQVFLALGGHYWppgrtvl---- 271
gi 29348324   177 HPHHKVIINTHAYMysddtrmgegdrwlpqkyglgkdtgenavnngeqmwdkLVSKYPNILFVFSGHVLnsgvgtlv--- 253
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                             
gi 2618853   1128 dgdgkpdrlVHQMLADY----QGGPEGGQGYLRLLQFdqandmVHVSTYSPY 1175
gi 19554254  1291 dgdgvddrtVTSMLFDY----QGLPEGGQGYLRLLHFdnqgqkMMVRTYSPS 1338
gi 164658656  265 --knaagrdVESHITNY----QNRYYGGAGMIRAYRFnmkenkIDVATFSPW 310
gi 21225892   272 --tndaghdVHVHITNY----QDRYYGGAGMIRTYGFdlvrgvVDVETFSPW 317
gi 29348324   254 -sigdhgnkVFQMLANFqdgvKGTNRGQTGFLRIVDIdvkkqqVRVKTYSPY 304

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