1MZB,2FE3,2FE3,2W57,2O03


Conserved Protein Domain Family
Fur_like

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cd07153: Fur_like 
Click on image for an interactive view with Cn3D
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators
Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.
Statistics
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Aligned: 369 rows
Threshold Bit Score: 78.7752
Threshold Setting Gi: 50954128
Created: 30-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding helix
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           ###############                              
1MZB_A        18 LPRVKILQMLdsa-eqrHMSAEDVYKALmeageDVGLATVYRVLTQFEAAGLVVRHNFDgg-haVFELAds---gHHDHM 92  Pseudomonas aer...
YP_076703     30 AQRAAICAALadmagkqHPTVQEIFEAArkhhpGVSLATVYNTLTVLKERGLVYELGPDaagavHYELDv----dTHVNV 105 Symbiobacterium...
NP_721026     31 KTREAVISYMins--rrHPSAEQIHKDLlpqypSMSLATVYNNLKVLIDEGFVVELKLSndntaYFDFMg----hQHLHV 104 Streptococcus m...
YP_713012     45 PARRAVLRVLagt--seHLSVDDVLTRAdeivpGLHRTTVYRALETLGELGLVTHVHPDhg-paVYHLAssltgsGHLHV 121 Frankia alni AC...
YP_643922      8 RQREAILAALrda--pgPLSAARIREAAereapGLGRATVYRALRTLREEGLVSVVELPge-epLYESSgr---gEHHHF 81  Rubrobacter xyl...
YP_644001     27 SQRRAVLEALkea--egHPSAEDVYLLVkrknpRVALGTVYQALSVLEEIGVVESKHWSes-ptRYDLNl----ePHLDI 99  Rubrobacter xyl...
YP_001321394  17 PQRLAVFQALkkr--kdHPNAESIYKDLeaaypTMSLATIYKSLELFIDLGLIQVINVGen-sfRYDGNn----eVHSHL 89  Alkaliphilus me...
YP_001512461  17 PQRIAVYQAIkes--tdHPNAETVFKKLyptypTMSLATVYKSLELFCNLRLIQVINIGen-sfRYDGRt----dEHQHI 89  Alkaliphilus or...
ZP_03471719   20 PQRLAVYNMLsht--kaHPNADTIYKELqplypTMSLATVYKALAILCDLGLAQELNVGee-afRYDADt----sHHPHI 92  Mitsuokella mul...
YP_001545785  26 PQREAVCWALarh--ggHPTAAEIVEVVkq--hGIGQATVYNTITTLEKLGVIQSMPLNtdehtRYDLDt----tPHMNF 97  Herpetosiphon a...
Feature 1                                                   
1MZB_A        93 VCVDTGEVIEFMdaeiEKRQKEIvr-erGFELvDHNLVLYVRK 134 Pseudomonas aeruginosa
YP_076703    106 ICIRCKQVIDLHhi-sTGLEEMVqa-etGYRLvGAQMLYYGIC 146 Symbiobacterium thermophilum IAM 14863
NP_721026    105 VCESCGKITDFVdt-dISHIKQEaykqtNYVItRAQLLIYGIC 146 Streptococcus mutans UA159
YP_713012    122 RCRRCGQISDVPadllDGVADRLar-qiGFRLqPDHAALTGLC 163 Frankia alni ACN14a
YP_643922     82 RCRGCGSILDLPgallRVPAGTLlp--gGHRVeECSLLLSGSC 122 Rubrobacter xylanophilus DSM 9941
YP_644001    100 RCVRCGRVEEVPgv-dAGDLESRiqentPYRVtRATMLLEGVC 141 Rubrobacter xylanophilus DSM 9941
YP_001321394  90 ICSQCARVEDLDns-iFQNSIPSvqeisNYKVeKQQFCFYGHC 131 Alkaliphilus metalliredigens QYMF
YP_001512461  90 ICTQCQKIEDLNnn-iFEDLKYKvaevsNYKInKQQLCFYGIC 131 Alkaliphilus oremlandii OhILAs
ZP_03471719   93 RCTCCGRVDDVPal-nTESVYEQvkdetGYALsDHQLYFFGVC 134 Mitsuokella multacida DSM 20544
YP_001545785  98 VCSQCGAIIDCHap-qLDLMLAQiastaGATFeAANVVVYGRC 139 Herpetosiphon aurantiacus ATCC 23779

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