Conserved Protein Domain Family
Fur_like

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cd07153: Fur_like 
Click on image for an interactive view with Cn3D
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators
Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.
Statistics
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PSSM-Id: 133478
View PSSM: cd07153
Aligned: 369 rows
Threshold Bit Score: 78.7752
Threshold Setting Gi: 50954128
Created: 30-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding helix
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           ###############                              
1MZB_A        18 LPRVKILQMLdsa-eqrHMSAEDVYKALmeageDVGLATVYRVLTQFEAAGLVVRHNFDgg-haVFELAds---gHHDHM 92
gi 51894012   30 AQRAAICAALadmagkqHPTVQEIFEAArkhhpGVSLATVYNTLTVLKERGLVYELGPDaagavHYELDv----dTHVNV 105
gi 24379071   31 KTREAVISYMins--rrHPSAEQIHKDLlpqypSMSLATVYNNLKVLIDEGFVVELKLSndntaYFDFMg----hQHLHV 104
gi 111222218  45 PARRAVLRVLagt--seHLSVDDVLTRAdeivpGLHRTTVYRALETLGELGLVTHVHPDhg-paVYHLAssltgsGHLHV 121
gi 108803985   8 RQREAILAALrda--pgPLSAARIREAAereapGLGRATVYRALRTLREEGLVSVVELPge-epLYESSgr---gEHHHF 81
gi 108804064  27 SQRRAVLEALkea--egHPSAEDVYLLVkrknpRVALGTVYQALSVLEEIGVVESKHWSes-ptRYDLNl----ePHLDI 99
gi 150391345  17 PQRLAVFQALkkr--kdHPNAESIYKDLeaaypTMSLATIYKSLELFIDLGLIQVINVGen-sfRYDGNn----eVHSHL 89
gi 158319954  17 PQRIAVYQAIkes--tdHPNAETVFKKLyptypTMSLATVYKSLELFCNLRLIQVINIGen-sfRYDGRt----dEHQHI 89
gi 218250013  20 PQRLAVYNMLsht--kaHPNADTIYKELqplypTMSLATVYKALAILCDLGLAQELNVGee-afRYDADt----sHHPHI 92
gi 159899538  26 PQREAVCWALarh--ggHPTAAEIVEVVkq--hGIGQATVYNTITTLEKLGVIQSMPLNtdehtRYDLDt----tPHMNF 97
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
Feature 1                                                   
1MZB_A        93 VCVDTGEVIEFMdaeiEKRQKEIvr-erGFELvDHNLVLYVRK 134
gi 51894012  106 ICIRCKQVIDLHhi-sTGLEEMVqa-etGYRLvGAQMLYYGIC 146
gi 24379071  105 VCESCGKITDFVdt-dISHIKQEaykqtNYVItRAQLLIYGIC 146
gi 111222218 122 RCRRCGQISDVPadllDGVADRLar-qiGFRLqPDHAALTGLC 163
gi 108803985  82 RCRGCGSILDLPgallRVPAGTLlp--gGHRVeECSLLLSGSC 122
gi 108804064 100 RCVRCGRVEEVPgv-dAGDLESRiqentPYRVtRATMLLEGVC 141
gi 150391345  90 ICSQCARVEDLDns-iFQNSIPSvqeisNYKVeKQQFCFYGHC 131
gi 158319954  90 ICTQCQKIEDLNnn-iFEDLKYKvaevsNYKInKQQLCFYGIC 131
gi 218250013  93 RCTCCGRVDDVPal-nTESVYEQvkdetGYALsDHQLYFFGVC 134
gi 159899538  98 VCSQCGAIIDCHap-qLDLMLAQiastaGATFeAANVVVYGRC 139

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