Conserved Protein Domain Family
ALDH_F9_TMBADH

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cd07090: ALDH_F9_TMBADH 
Click on image for an interactive view with Cn3D
NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
NAD+-dependent, 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH, EC=1.2.1.47), also known as aldehyde dehydrogenase family 9 member A1 (ALDH9A1) in humans, is a cytosolic tetramer which catalyzes the oxidation of gamma-aminobutyraldehyde involved in 4-aminobutyric acid (GABA) biosynthesis and also oxidizes betaine aldehyde (gamma-trimethylaminobutyraldehyde) which is involved in carnitine biosynthesis.
Statistics
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PSSM-Id: 143409
View PSSM: cd07090
Aligned: 16 rows
Threshold Bit Score: 732.569
Threshold Setting Gi: 167535615
Created: 14-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1BPWL: Cod Liver Betaine Aldehyde Dehydrogenase with bound NAD+, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9792097

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1BPW_A        40 VFEPATGRVLCQMVPcgaeEVDQAVQSAQAAYLKWSkmAGIERSRVMLEAARIIRERRDNIAKLEVINNGKti-tEAEYD 118
gi 167535615  52 WIEPATKQAHVRVEAaamaDLDEALQGAQAAQQQWAltSGMERARALMDVAHYLRTHTTACESIECLDTGRpfreMALAD 131
gi 159123780  28 TINPADNTPLAEIHVasnsDTDAAIAAADRAFPLWSqtPHIARARILQKAAALLRERNDELARLETLDSGKayseTSTVD 107
gi 122320924  26 TFDPATGELLAQVQQasaaDVDRAVASAREGQREWAamTAMQRSRILRRAVDLLRERNDELAAIETRDTGKpigeTLAVD 105
gi 123344326  26 TINPANGNVLATVQAagreDVDRAVKSAQQGQKIWAamTAMERSRILRRAVDILRERNDELAKLETLDTGKayseTSTVD 105
gi 85541005   26 VIYPATGETIAMLRSatpnVLELAIEAARAAQPAWArlKPVERGRILRRAADILRARNADLARIETLDTGKaiqeTLVAD 105
gi 126645972  22 NYNPATGEITHVVTGasqeDFEKAVQSAKKGFQVWSamSPTERGRILHKASALLREKNDELALLETQDVGKpikeSIAVD 101
gi 195999056  62 IREPATNKLIGNLSSsgpkTVNDGVKSALSAFPEWSaqTSIDRGRALLRISKLLRQRNEEIARLEVRDTGKpi-sEARCD 140
gi 198413878  58 VIEPATGKVMCQMHEcgatDVNNAVNAAKQAQLEWGklSGFERGKILSKSSVLLKQKQEEIARMEVYDTGKpi-qEARVD 136
gi 71995606   31 VIEPRIGQVVAKCPKatadIVDQYVKAAADAQSAWGetTALDRGKVLHKVADLIREHAEEIAIWEVKTNGKpi-yEARCD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        ## ##                      #    
1BPW_A       119 IDAAWQCIEYYAGLapt--lsGQHIQLpg---gAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPm 193
gi 167535615 132 LPSVIDSFEYFAGVaqr--vsGEHYDMgg---gSFAYTRREPLGICAGIGAWNYPMQGAAWKAAPAMATGNALVFKPSEh 206
gi 159123780 108 IVTGADVLEYYANLvgggglnGETTHLre---dAWVFTKKAPLGVCVGIGAWNYPLQIALWKSAPCLAAGNTMVYKPSEy 184
gi 122320924 106 IVTGADVIEYYAGLata--ieGLQVPLra---eSFVYTRREPLGVCAGIGAWNYPIQIACWKTAPALAAGNAMVFKPSEv 180
gi 123344326 106 IVTGADVLEYYAGLips--leGSQIPLre---tSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEv 180
gi 85541005  106 APSAADCLEYFGGAvaa--ynGEAVDLg----gPFAYTRREALGVCVGIGAWNYPIQIAGWKSAPALAMGNAMVFKPSEn 179
gi 126645972 102 VISGADCLEYYAGLaps--lhGEHFELg----gDFAYTKREPLGICAGIGAWNYPIQIACWKAAPALACGNVMIFKPAEl 175
gi 195999056 141 VESAAECFEYFGGIaat--lsGQHFEFan---gSFAYTKREPLGVCVGIGAWNFPIQIVSWKTAPALACGNTIVYKPSQm 215
gi 198413878 137 VQTAIDSIEYFSGIast--lcGQHFSLpn---gSFGYTRREPLGVVAAIGAWNYPIQIAAWKAAPALATGNAVVCKPSQf 211
gi 71995606  110 IASSADTFDFFGGIata-vlqGDSLELpggpsqRIAYTRREPYGVVGCIGAWNYPFQTCVWKVAPALAAGNAVVYKPSPf 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #                  # ##  #                  ###     
1BPW_A       194 tPVTGVILAEIFHe-AGVPVGLVNVVQGGAe-TGSLLCHHPnVAKVSFTGSVPTGKKVMEMSAk-tVKHVTLELGGKSPL 270
gi 167535615 207 tPLSALLLAEAVQqvEAIPTGLFNVVLGDGa-LGATFATNPsFAKVSFTGSRATGLKITSAAAg-dLKRVTMELGGKSPL 284
gi 159123780 185 tPLHAQMLAEIYRe-AGLPPGVFNVVYGAGd-VGAYLTAHPlVAKVSFTGQVSTGMKVAGSAAg-qMKYVTMELGGKSPL 261
gi 122320924 181 tPLTALKLAEIYTe-AGVPAGVFNVVQGDGs-VGALLTGHPdIAKVSFTGGVETGKKVMSLAGassLKEVTMELGGKSPL 258
gi 123344326 181 tPLTALKLAEIYSe-AGLPDGVFNVLPGVGaeTGQYLTEHPgIAKVSFTGGVASGKKVMANSAassLKEVTMELGGKSPL 259
gi 85541005  180 tPLSALALAEIYSe-AGLPDGLFNVVQGYGd-VGAGLVGHDvVAKVSVTGSVPTGRKVLSLAGs-kMKHATMELGGKSPL 256
gi 126645972 176 tPLTAYKLAEVFRe-AGMPDGVFNVVQGDAe-VGQMMTAHPdIAKVSITGEVGTGKKVMAASAn-tLKHVTLELGGKSPI 252
gi 195999056 216 tPMSSSLLGDIITe-AGLPLGCYNVVQGGSq-TGRLLCEHPsVAKVSFTGSVPVGKKIMSYCSs-gVKHSTIELGGKSPL 292
gi 198413878 212 tPLTAVALAEVFIe-GGLPSGLFNVVQGAGe-TGNHLTRHPdVAKVTFTGSIETGSKVMQNCAa-dIRHVTLELGGKSPL 288
gi 71995606  189 aPASPVLLGEILTa-AGVPKGVYNVIQGEQe-AGVALCEHNlVAKVSFTGSVASGEAVQRQAAtknVKPVTLELGGKSEI 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                                                     
1BPW_A       271 LIFKDcELENAVRGALMANFLTqGQVCTNGTRVFVQreiMPQFLEEVVKRTKAIv-VGDPllteTRMGGLISKPQLDKVL 349
gi 167535615 285 IICADaDLEQACRGAIMANFFSnGQVCSNGTRVFVArevYQPFTQRLVELTAQLr-AGDSfdeqVAVTPVIHNDHAARVR 363
gi 159123780 262 LILPDaDLENAVNGAMMANFFStGQVCTNGTRVFVPrgmKSAFEKALLDKMQYIr-PGPLfdnaTNFGPLSSALHLEKVT 340
gi 122320924 259 IVFEDaDLDRAADIAVTANFFSsGQVCTNGTRVFVHrsvKDAFTQRVLERVKRIr-VGKPtdaaTNFGPLVSAAQLDKVL 337
gi 123344326 260 IVFDDaDLELAADIAMMANFFSsGQVCTNGTRVFVPakcKAAFEQKILARVERIr-ADDVfdpqTNFGPLVSFPHRDNVL 338
gi 85541005  257 IVFDDaDIENAIGGAMLGNFYStGQICSNGTRVFVQsgiHDRFVERLVERTKKIr-IGNPldpeTQMGPLVSKAQHEKVV 335
gi 126645972 253 IIFEDaAIDEAVYGAMLGNFYTqGEICSNGTRVFVHesiKEKFIERLIEKTKELk-IGNPadseTQIGALINKTHFEKVM 331
gi 195999056 293 IVFPDsDIDNAVSGTLMANFLSqGQVCSNAARVYIHdsiIDDFVTRLMERTKKMi-IGDPfkqeTQVGALISEEHYHRVK 371
gi 198413878 289 ILFGDcDITNAVNGALMANFLSqGQVCSNGTRVFIQddiYDEVVTMLVERTLGIk-HGDPhhehTKMGAMMNEEHAHKVM 367
gi 71995606  267 IIFDDsDVKSAVASAMLANFLNqGQVCTNATRVFVQkgiLASFTEAIVQEANDKlkVGDPlledTRVGANINEGHLQRIL 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                            # #                         
1BPW_A       350 GFVAQak-keGARVLCGGEPltpsd-pklknGYFMSPCVLDNcrddMTCVKEEIFGPVMSVLPFDtEEEVLQRANNTTFG 427
gi 167535615 364 EFLERar-tqGATVLYGGEYadeevpshidrTGLIKPHILTDcsddMEIVREEVFGPVMAVLPFDtVDEAVRRANDTPYG 442
gi 159123780 341 SYIRHgietdKATLLYGGLGkpslp-kdlenGFWVRPTVFTDctdsMRIVQEEIFGPVMSILYYDtVEEAVRRANNTELG 419
gi 122320924 338 GFIDSgk-aeGAKLLAGGTRltdg---hfasGQYVAPTVFGDcrddMKIVREEIFGPVMSILDFEsEDEVIARANDTHYG 413
gi 123344326 339 RYIAKgk-eeGARVLCGGDVlkgd---gfdnGAWVAPTVFTDcsddMTIVREEIFGPVMSILIYEsEDEVIRRANDTDYG 414
gi 85541005  336 GYIGIgk-qdGAVLACGGNVpslq---gfdgGFFVEPTVFTGvtdtMRIAREEIFGPVMSVLKFDgEDEVIDRANDTEFG 411
gi 126645972 332 SYIALgk-eqGAELRYGGNSiavd---gcegGYFVEPTIFVSndeeDRIVKEEIFGPVMTILTFQeEEDVIRRANDTPFG 407
gi 195999056 372 AYIDQav-teGARIRCGGERvvfdn-selagGFYMSPCVLDSchddMTIVKEEVFGPVVSILSFKdEEEVLERANNTVFG 449
gi 198413878 368 GFIERak-keGAEVLCGGELvqmed-pvlrgGSYISPCIIRPsd-sMEISREELFGPVMNVYSFKtEDEVIRRANDSKYG 444
gi 71995606  347 GYVESak-qeGGVVLRGGVRvhpt---gvegGAYFEPAIITGlsdeARAVREEIFGAVMLILPFEtEEEVIARANNTTYG 422
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #                               
1BPW_A       428 LASGVFTRDISRAHRVAAnLEAGTCYINTYsiSPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVEMG 497
gi 167535615 443 LSAGVFTQDLKQAHRVIAeLKAGTTWINDYnlAPTQLPWGGYKQSGVGRENGTDAINHWTQLKRIGSRER 512
gi 159123780 420 LAAGVFTRDLNMAHRIIDqLQAGITWINSWgeSPAEMAVGGWKKSGVGVENGRRGIEAWVRNKSTLVDMN 489
gi 122320924 414 LAAGVVTENLSRAHRTIHrLEAGICWINTWgeSPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELG 483
gi 123344326 415 LAAGIVTADLNRAHRVIHqLEAGICWINTWgeSPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMA 484
gi 85541005  412 LAAGVFTRDLPRAHRVIAeLQAGTCWINAYnlTPVEIPFGGFKQSGIGRENSLAALALYSQLKSIYVETG 481
gi 126645972 408 LAAGVYTNDMRRAHRSVAsLQAGMCWINTYniNPVEIPFGGNKQSGIGRENGLAAIEHYSQLKTVYVAMK 477
gi 195999056 450 LSAGVFTKDIQRAHRVIAkLQAGSCWINNYniYPTGFPFGGYKESGIGRENCAQTLNHYSQLKTVYVEMG 519
gi 198413878 445 LASGVFTKDIQRAHRVAAsMQAGSCYINNYniFPIEMPFGGYKKSGLGRENGTVTVDYFTQLKTVYVEMN 514
gi 71995606  423 LAAGVFSGNLARGHRVAArLQAGTVFINTYndTEVNVPFGGFKNSGHGRENCIDTLRAHTQTKAIYVNVQ 492

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