Conserved Protein Domain Family
GT_MraY

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cd06852: GT_MraY 
Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with possibly ten transmembrane domains.
Statistics
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PSSM-Id: 133462
View PSSM: cd06852
Aligned: 134 rows
Threshold Bit Score: 203.488
Threshold Setting Gi: 210613091
Created: 21-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Mg++ bindingputativeputative
Feature 1:Mg++ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    ##                  
gi 61214073   61 GPETHFKKKGVPTMGGLLILLSVTVSTLLWarld------nplIWLVLLVTLFFGMIGAYDDYKKiskk---tseGLSAK 131
gi 206901310  39 GPSSHFQKSGTPVMGGIVFILAVFPFLFFKe------------TFFISLSTILFGLLGLVDDLKLmen----kdyGIRPL 102
gi 192808691  39 LPPDHQAKRGTPLMAGLILLIGIGMSLQFQpt---------plTVFLCSTFLLFSSIGFMDDFKKaawq---dpsGISGR 106
gi 15806835   33 GPQTHLAKEGTPTAGGVAFVLALLLVFVGLlafggigqanlsrEVMILLAALGMGVVGGIDDFLKirsrkfggkkELLAR 112
gi 196236173  32 GPRSHLAKEGTPSMGGVAFLLAAFLAYWALgm---------dgLRGLWLLGLGFALLGLLDDLSGsl------krPLRAR 96
gi 213015319  39 GPDLHNYKTGTPTAAGLVFIPIFIAVLLNFnrg--------peSFLIAFSALSYGLIGAIDDFMKikrk---nasGITAV 107
gi 42527751   56 FTVNPEAAVGKPTGGGVVFISIFVLCVFLLiip-------tltQGLVLVITFAVMLTGFLDDRSEk---------SWGEY 119
gi 160945479  45 FAVNGELSKGKARGSGLIFVLCIALVSLAFlpf-------tteYVVYNVLLIASMLSGYLDDAAEt---------AWNEY 108
gi 210613091  46 FAINGKLSKGKIRGVGLTFVLCFIISSILFlpi-------dreYIIYLILLFCVMLSGYLDDAADt---------PWSDY 109
gi 15639336   67 FAPCAQEAAGKPTGAGVIFVSVFVLLVYLLmrp-------sfvHALILLLTWGVMLTGYLDDCAQv---------CWGEY 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 61214073  132 GKLLLQIAGALIVGFFVYlhpgydgqlsi-pfmknvqpdlgWFYIVFAVIVIVGASNAVNLTDGLDGLAAGPMVVSSAVY 210
gi 206901310 103 RKIFLSFIITLILYVFSPhdykiywg-------shliidssILYIFLFFIILIAVPNAINLTDGLDGLAGGTSLVTLIFL 175
gi 192808691 107 TKLVLQFLFTGALLYVLFqsfsltsdial--fngfqlhlpiSVYIVIMLLFIVGSANAINFTDGLDGLLINVAIPTYFFF 184
gi 15806835  113 EKFPLQVLVALLFAGFAAplashqllp-----gfmsiggypIFDMLFIAFVMVGSVNAFNFTDGLDGLLAGVGMIVLLPL 187
gi 196236173  97 EKLFFQTLMALVFALWAVrqvay--------------tpwpILDVLLILLAVVGAANAFNFTDGLDGLLASLTAVLLIPF 162
gi 213015319 108 QKLFMQFTAAFIIVYFIQqinphtyliv---pfsgykldlgWFYYLLSSVVIVGVSNAVNLTDGVDGLAGFVFIGSIVPL 184
gi 42527751  120 LKGGLDFILSAVTALVIFyiyfegkvsfwlpfisnlvevhpIVFFVVSIMILWISINTTNCTDGVDGLSGTLILLALVSL 199
gi 160945479 109 KKGIIDFVIAVLAGVTYLnfngcgvhf-----lqwsftlpyAVYLLLIVILIWASINVVNCTDGVDGLSASLAVVTIGTY 183
gi 210613091 110 KKGFIDLIISIVTMLTFVnynttvihf-----fetelvipkAVYVILGIILIWVSINVTNCSDGVDGLCASLCTVSLISF 184
gi 15639336  131 RKGALDFLFAVLTAALLGhfyfhdqvfwwfpffsdpvfvspFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSM 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 61214073  211 LLFAYlagnvvlanylhip-yvagsgelaifcgTLFGACLGFLWFNAHPAQMFMGDVGSLALGGALGSIAIIIKqefLLA 289
gi 206901310 176 LVYSFhfkki------------------aleisLMITALLAFLWFNSHPAEIFMGDVGAFALGGFIASLSVVNKvelLLI 237
gi 192808691 185 FLISDkpevq-------------------mfslVMIGCLLGLLLYNIHPARAFMGDTGSLAIGGSLSFLAVIEKveiLIP 245
gi 15806835  188 VAVSPia-------------------------aLMVAVLLGFLWFNAHPARVFMGDMGSHAIGAVAAGAYALYSdvwLLP 242
gi 196236173 163 YPLPLa--------------------------qTLLGGVLGFLWHNAPKAKVFMGDTGSQALGAMVAGLFILTGklwLLP 216
gi 213015319 185 LIVGYqsv----------------------vylSLIGLLMGFLWHNWHPASIFMGDAGSLALGGILATSFALNGlelFLI 242
gi 42527751  200 GIVFYfvlghvkvaayllvpnistgakwavmifTLCGVLTGYLWHNAYPSKVLMGDAGSRALGFFIGVLVIISRnpfILL 279
gi 160945479 184 LLAYKtelgay-----------------atagvVFIGALLAYLWLNAKPSSLLMGDAGSRAMGFFIAMLSLKCGhpfAFL 246
gi 210613091 185 SLIFKdvlgmy-----------------tnanfLFVAVLLAYLYFNTSPSSMLMGDAGSRALGFYLAIITVKSGhpfLYI 247
gi 15639336  211 GTIFYfllgnvraaqyllvpfvvdgaqwalmsfALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGnpfLLL 290
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                            
gi 61214073  290 IVGGVFVMEALSVMLQVGYFRms-kgKRIFLMAPFHHHFEk-kGWSEPKVVVRFWIVSIILGLFAIAT 355
gi 206901310 238 FLSGIFLIESLSVFIQVFFYKwk--kKRIFLMSPIHHHFEl-kGWKETKIVWRFYIIHLLIIIGGLVL 302
gi 192808691 246 LLFLIYLAEQLSVILQVWYYKrt--kLRLFRMAPIHFHFSlkyGWSENKIVMIFGFVSWFMALLCWVL 311
gi 15806835  243 IAAIIPVAAVLSVVIQVASVRlr--kRKVFKMSPIQHHFEl-sGWPETHVTLRFWVVTGIATALTWWL 307
gi 196236173 217 LAAIVPVLEVLSVVAQVLYFRkt--gRRLLRMSPLHHHFEl-iGWEEAKIVFRFAILTGLATALAFGG 281
gi 213015319 243 FFGFIFLLETLSVIIQVTSFKfr--gKRVFRMSPIHHHFEl-lGWKEEKIAFRFSTLALLVSLLGIIG 307
gi 42527751  280 MTSCVILINGGTGILKVVMLRffkirIFKNIRFPLHDHMKknlQWSPTQVLIRFVIVQILITIVILGI 347
gi 160945479 247 LAAIVFIADGSLGILKISLKRflhiwILKNTLTPLHDHVRkrkGWSDEQVVARWLILQCVASALLLLL 314
gi 210613091 248 LLAAVLIVDGGLGLVKIFLKRflkisILKNTRTPIHDHLRknhNWSDTQVVIRFIIIQVICSVLAFLL 315
gi 15639336  291 MTSGVILVNGGTGLLKVVLLRffhvrILSRVRFPLHDHMRenwHWSTAQVLLRFMILQGLLTIGLLGV 358

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