1BQ0,1FPO,1N4C,1WJZ,2CTQ,2CUG,2DN9,2GUZ,2O37,2OCH,2QSA,2QWO,2YS8,2YUA,3BVO


Conserved Protein Domain Family
DnaJ

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cd06257: DnaJ 
Click on image for an interactive view with Cn3D
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.
Statistics
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PSSM-Id: 99751
View PSSM: cd06257
Aligned: 153 rows
Threshold Bit Score: 36.3693
Threshold Setting Gi: 74583836
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
HSP70
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:HSP70 interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     ###                     #  ##  ##  
1BQ0           4 DYYEILGvs-----------------ktAEEREIRKAYKRLAMKYHPDRnqgd-------------keaEAKFKEIKEAY 53
2QWO_B        17 NIRALLStmhtvlwagetkwkpvgmadlVTPEQVKKVYRKAVLVVHPCKatgqp----------yeqyaKMIFMELNDAW 86
gi 1176018    44 NFYKFLKlpk---------------lqnSSTKEITKNLRKLSKKYHPDKnp----------------kyRKLYERLNLAT 92
gi 1723433    32 TPYEILElp-----------------rtCTANDIKRKYIELVKKHHPDKmknasqlaptesppeinkhnEEYFRLLLAAN 94
gi 74626639    9 DCYEILQvn-----------------hdSDLQEIKANYRKLALQYHPDRnpgi-------------edyNEIFSQINAAY 58
gi 74765414 1564 EFHNILSih-----------------edRDLMELKRILYNLFLEYNPHMnnkq------------kaelDKKFSEMNVVH 1614
gi 74873101  500 TYYDILNvy-----------------ptSELSEIKSNYYNLALKYNPESnlgn-------------aeaLTKFRDINEAY 549
gi 74873221  697 TYYDLLNve-----------------pdASFDEIKHSYRKLALQYHPDKnind-------------peaNEKFQKINEAY 746
gi 74873222  195 TYYDILNin-----------------anSKLEEIKEKYYEVASKYHPEKnign-------------dkaFKKFELINSAY 244
gi 75027238    3 DFYELLNvp-----------------stASFDEIKCSYKQLILQCHPDKlrqlddp------npgseaqNSDFNAINAAW 59

                 ....*
Feature 1             
1BQ0          54 EVLTD 58
2QWO_B        87 SEFEN 91
gi 1176018    93 QILSN 97
gi 1723433    95 ALLSD 99
gi 74626639   59 NILSN 63
gi 74765414 1615 QILNY 1619
gi 74873101  550 QILSL 554
gi 74873221  747 QVLSD 751
gi 74873222  245 QILSN 249
gi 75027238   60 NTLKD 64

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