Conserved Protein Domain Family
Bromo_TFIID

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cd05511: Bromo_TFIID 
Click on image for an interactive view with Cn3D
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99943
View PSSM: cd05511
Aligned: 19 rows
Threshold Bit Score: 147.796
Threshold Setting Gi: 116058617
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 #    #  #                                      #   #    
1EQF_A         27 LSSILESIINDMRDLpnTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRlYPSREEFREHLELIVKNSATYNGP-- 104
gi 85857444  1475 LSSILEIIHNELRSMpdVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRrYTSREMFLEDLKQIVDNSLIYNGP-- 1552
gi 113677837 1451 LSSVLESIINDMRDLpnTYPFHTPVNGKVVKDYYKIITRPMDLQTLRENVRKRmYPSREEFRESVELIFKNSATYNGA-- 1528
gi 108878153 1450 LSSLLEQILNELRDMpdVAPFMFPVNAKQVVDYHKIIQRPMDLQTIREHIRQKkYQTRDEFIADINQIVENSSLYNGA-- 1527
gi 39581477  1399 LSTMLTDVLNELKSLegSDAFLFPVNPKQVTDYYNIIKNPISFQDIKNKIASYsYQLRKEFIEDIRLMHGNSRMYNGE-- 1476
gi 39581477  1521 FCFVLDQIIQKVRNIpkSAPFHTKVDGKRFPSYYVRIQNPIDLGTIEQKNKRHeYQSIDDFLKDMRLILDNSLAFNGE-- 1598
gi 17509345  1583 FSYLLGEIVQKMKNIpkSALFHTRVDPKKIPAYYLKISDPMDLSIMEQKSKSQeYKSIDEFLKDAEKIYTNSVVFNGA-- 1660
gi 115670833 1463 MSGILEEILNAIRELpyTQPFHTAVEKRKFPDYYKIVSKPIALQTIRDNVRKHrYASRDSFEADINQIVDNSILYNGE-- 1540
gi 158592169 1429 MSIVLSEIFNDVRSIsgCEEIMFPVNPKKVPDYYNIIKEPMDLQQIKTKISENkYELRRQFLYDIKLIMDNSILYNGG-- 1506
gi 158592169 1551 FSFILNEIVQECKNIpkSVAFHFKVDPKKLPQYYEKIHKPMDLGTMQQNIKEHrYTTVEAFRNDIKQIRMNSELYNGPpe 1630
                          90       100       110
                  ....*....|....*....|....*....|....
Feature 1            #                              
1EQF_A        105 KHSLTQISQSMLDLCDEKLKEKedkLARLEKAIN 138
gi 85857444  1553 QSAYTLAAQRMFSSCFELLAERedkLMRLEKAIN 1586
gi 113677837 1529 KHPLTVVAQAMLSLCVEKIKEKeerLVRLEKAIN 1562
gi 108878153 1528 KSSLTIAAQRMLQKCKDRMQEKeerLTRLEKSIN 1561
gi 39581477  1477 NHVLTMNAADILKRAGFLLALRdseFMKLEKQIN 1510
gi 39581477  1599 ASIYTAKAKEIWQLTERLVQENmetLVELEKNIN 1632
gi 17509345  1661 ESVYSLKAKEMFEMAEMLVKDQmdtLGELERNIN 1694
gi 115670833 1541 MSPLTMVAKNMLLMAQKKMQEKterMSRLEMAIN 1574
gi 158592169 1507 GHSITITAKNVFEMASRYVAEReqkLIALEKAIN 1540
gi 158592169 1631 TSQYTSKAVEICTLAEKMLEERkeqLAELEMNIQ 1664

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