1Y6J,2V6B,2V6M,1A5Z,1LLD,2E37


Conserved Protein Domain Family
LDH_2

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cd05292: LDH_2 
Click on image for an interactive view with Cn3D
A subgroup of L-lactate dehydrogenases
L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed predominantly of bacterial LDHs and a few fungal LDHs. Bacterial LDHs may be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133428
View PSSM: cd05292
Aligned: 48 rows
Threshold Bit Score: 438.463
Threshold Setting Gi: 211960008
Created: 14-Dec-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###                    ##   #                                        #  
1Y6J_A         8 SKVAIIGAGFVGASAAFTMALRQTANELVLIDVFKEKAIGEAMDINHGLPFm--GQMSLYAGDYSDVKDCDVIVVTAGAN 85  Clostridium the...
1A5Z_A         1 MKIGIVGLGRVGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFt--RRANIYAGDYADLKGSDVVIVAAGVP 78  Thermotoga mari...
1LLD_A         8 TKLAVIGAGAVGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFy-pTVSIDGSDDPEICRDADMVVITAGPR 86  Bifidobacterium...
P62051         2 NRIAVIGVGNVGMAFAYAAAIKRLANDIVLIDANAARAEGESMDLADAMALv--GPVQIRSGGYEQCEGARIVVVTAGAK 79  Desulfovibrio v...
Q7NG49        21 IKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFv--EPSVVRAGTLADCRGVDVVVITAGAR 98  Gloeobacter vio...
YP_055601     14 SKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFt--PASVMGGADVHDTADSDVVFITAGAR 91  Propionibacteri...
YP_001615888  10 SKVAIVGAGSVGATIAYACLLRGVAKQIALFDVNRAKVGAEVLDLNHGLQFv-pAATLDGSDDVEVCRGADVVVITAGAK 88  Sorangium cellu...
ZP_03279098    4 NTVGIIGTGNVGMAAAYALFQRQIASSLVLVDKDPRRAEGEAMDLMHGQALv--GRVTVRAGDYADLAGCGVIVICAGVG 81  Thioalkalivibri...
YP_833453      4 SKLAVVGAGSVGTSLAYAALIRGSASNIALFDVNALKAEAEVLDLAHGTQFaaaAATVTGGGDIAVTEGADVVVITAGAK 83  Arthrobacter sp...
YP_001854354  12 TKIGIVGAGSVGTSLAYAAMIRGTSTDIALYDLQTAKVEAEALDLSHGQMFa-pGVRVEGSDDVAVLKDADIIFVTAGAK 90  Kocuria rhizoph...
Feature 1                     #                        #                                         
1Y6J_A        86 RKPGETRLDLAKKNVMIAKEVTQNIMKYyNHGVILVVSNPVDIITYMIQKWsgLPVGKVIGSGTVLDSIRFRYLLSEKLG 165 Clostridium the...
1A5Z_A        79 QKPGETRLQLLGRNARVMKEIARNVSKYaPDSIVIVVTNPVDVLTYFFLKEsgMDPRKVFGSGTVLDTARLRTLIAQHCG 158 Thermotoga mari...
1LLD_A        87 QKPGQSRLELVGATVNILKAIMPNLVKVaPNAIYMLITNPVDIATHVAQKLtgLPENQIFGSGTNLDSARLRFLIAQQTG 166 Bifidobacterium...
P62051        80 QMPGQSRLDLVRVNAGITRDILTAVMQYaDDPLYIMATNPVDVLTHVARTVtgVAPGRVIGSGTVLDSARFRGHVAEILG 159 Desulfovibrio v...
Q7NG49        99 QREGETRLSLVQRNVEIFRGLIGEIMEHcPNAILLVVSNPVDVMTYVAMKLagLPPSRVIGSGTVLDTARFRYLLAERLR 178 Gloeobacter vio...
YP_055601     92 QKPGQTRLDLAGVNANILRSLMPQLVEQsPNALFVLVTNPCDVLTVVAQEAtgLPANRVFSTGTMLDTSRLRWLIRQWAN 171 Propionibacteri...
YP_001615888  89 QKPGQSRMDLATANVAICRELLPRLLAVaPDALYLLVTNPVDVITYVTLKLtgLPPARVIGSGTVLDSSRFRFLIARQLD 168 Sorangium cellu...
ZP_03279098   82 QKPGETRLDLLNRNAAVFREIAEQLDRNaPEAVLVIATNPVDILTTVMQRLskRPPEAVIGTGTMLDTSRFRALLGEHYD 161 Thioalkalivibri...
YP_833453     84 QAPGQTRLDLAGTNVGILEQLMPQLLQQaPDAVYVLVTNPCDVLTVAAQKIsgLPPERVFSSGTVLDTSRLRWLLARRAG 163 Arthrobacter sp...
YP_001854354  91 QKPGQTRLDLAGANTAILKSLMPQLVEQaPQAVFVLVTNPCDVLTVVAQQItgLPHQRIMSSGTVLDTSRLRWLIGSEAQ 170 Kocuria rhizoph...
Feature 1                                                                            ##          
1Y6J_A       166 VDVKNVHGYIIGEHGDSQLPLWSCTHIAGKNINEYIddp-kcnFTEEDKKKIAEDVKTAGATIIKNKGATYYGIAVSINT 244 Clostridium the...
1A5Z_A       159 FSPRSVHVYVIGEHGDSEVPVWSGAMIGGIPLQNMCqvc--qkCDSKILENFAEKTKRAAYEIIERKGATHYAIALAVAD 236 Thermotoga mari...
1LLD_A       167 VNVKNVHAYIAGEHGDSEVPLWESATIGGVPMSDWTplpghdpLDADKREEIHQEVKNAAYKIINGKGATNYAIGMSGVD 246 Bifidobacterium...
P62051       160 VDVRGVHAHIVGEHGDSEVALWSRANVSGIPVAEMCarr-giaYDAAFREKALGHVRHAAYEIIGRKGATGYGIGMSLCR 238 Desulfovibrio v...
Q7NG49       179 VDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEpav-gtpDDPAKMFEVFEHVKNAAYEIIERKGATSWAIGLATTQ 257 Gloeobacter vio...
YP_055601    172 VEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAvdg-nrvFTEDVLADLAHEAAYAAYKIIEGKGATNYAIGLTGAR 250 Propionibacteri...
YP_001615888 169 VAVQNVHAYIAGEHGDSEVPLWSSASVANIPLDAWSvpg-hghLGATERAEIFSNVKNAAAQVISGKGATNYAIGLATAK 247 Sorangium cellu...
ZP_03279098  162 VNPRSVHAYILGEHGDSEVAIWSSASIGGLPIMGHEisc--kpFDAGAMERIFQQVRGAAYDIIARKGYTNTAIGLVIAY 239 Thioalkalivibri...
YP_833453    164 VSVASVHASMVGEHGDTEFPVWSGATIGPVPILDWEadg-eriFTPEYLAETAQEVTQAAYKVIAGKGATNYAIGLSGAR 242 Arthrobacter sp...
YP_001854354 171 VNTSSVHAYIIGEHGDSEFPVWSSASIGQVPLSEWEvdg-hrpFTPERLDELKDQVVNAAYRVIEGKGATNYAIGLAGVR 249 Kocuria rhizoph...
Feature 1                                                                                
1Y6J_A       245 IVETLLKNQNTIRTVGTVINGmyg-iedVAISLPSIVNSEGVQEVLQFNLTPEEEEALRFSAEQVKKVLNEV 315 Clostridium thermocellum
1A5Z_A       237 IVESIFFDEKRVLTLSVYLEDylg-vkdLCISVPVTLGKHGVERILELNLNEEELEAFRKSASILKNAINEI 307 Thermotoga maritima
1LLD_A       247 IIEAVLHDTNRILPVSSMLKDfhg-isdICMSVPTLLNRQGVNNTINTPVSDKELAALKRSAETLKETAAQF 317 Bifidobacterium longum ...
P62051       239 IVEAILHDEHSVLTVSCPVAGhyg-lgdVSLSLPCVIGSDGIEEVLDAPIAEDEQAALAASARVLGEHLAAL 309 Desulfovibrio vulgaris ...
Q7NG49       258 IVRAITRNQNRVLPVSVLMSGlhg-ieeVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSARVMRQTLDGI 328 Gloeobacter violaceus
YP_055601    251 LAEALLRPGRSVLPLSSVMTDmhg-isgVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLHDTLSSI 321 Propionibacterium acnes...
YP_001615888 248 ILEALLRDENRVLPVSSLLSGyrg-iddVCLSVPCIVNRSGVESQLPIPMSSEEEAGVRASADTIRKAIRSL 318 Sorangium cellulosum 'S...
ZP_03279098  240 LVRVILEDQKSVLPVSVDPAGiygiepgLCLSIPCVVGSRGVECRVPPEVSEQERAGLHASAAVLRGGLEGM 311 Thioalkalivibrio sp. HL...
YP_833453    243 IVEALLRDENAVLPVSTVLDGpyg-isgVALSLPSVVGRGGVHRILHTPMDDGELAALQHSADTLRNTMGTL 313 Arthrobacter sp. FB24
YP_001854354 250 IAEAVLKDQQSVLSVSTVLEDyyg-vsgVALSVPSVVGGTGVGQQLRIPMGEPEKQQLRASAETMRASLRDL 320 Kocuria rhizophila DC2201

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