1WXJ,1RD5,1TJP,1V7Y,1WDW


Conserved Protein Domain Family
Tryptophan_synthase_alpha

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cd04724: Tryptophan_synthase_alpha 
Click on image for an interactive view with Cn3D
Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both strongly stimulated by the formation of the complex. The alpha subunit catalyzes the cleavage of indole 3-glycerol phosphate (IGP) to indole and d-glyceraldehyde 3-phosphate (G3P). Indole is then channeled to the active site of the beta subunit, a PLP-dependent enzyme that catalyzes a replacement reaction to convert L-serine into L-tryptophan.
Statistics
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PSSM-Id: 240075
View PSSM: cd04724
Aligned: 161 rows
Threshold Bit Score: 127.978
Threshold Setting Gi: 119873395
Created: 11-Jul-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1TJP; Salmonella typhimurium tryptophan synthase with bound 1-[(2-Hydroxylphenyl)amino]3-glycerolphosphate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #          #                                     
1WXJ_A       17 ALIPYLTAGFpsregFLQAVEEVLPy-aDLLEIGLPYSDPLGDGPVIQRASELALrkgmsvqgaLELVREVRalt-ekPL 94  Thermus thermoph...
1TJP_A       18 AFVPFVTLGDpgieqSLKIIDTLIDagaDALELGVPFSDPLADGPTIQNANLRAFaagvtpaqcFEMLALIRekhptiPI 97  Salmonella typhi...
Q9Y8T3        7 GFSVYLTIAWpspdtFLEIASTLKGc-vDYLELGIPTPKPLYDGPTIRLTHLKAVesgysgpktLSLAEEASqea-gvPY 84  Aeropyrum pernix K1
BAB60198      2 KPFVYFTLGYky-neVKKFIKNSDGv--YAFEFGFPTENPLYDGKKIKATHSFAVnkfs-hddnAEIFKLAEsm--giKK 75  Thermoplasma vol...
P50382        6 MLVVYMTLGYpnvqsFKDFIIGAVEngaDILELGIPPKYAKYDGPVIRKSYDKVKgl-----diWPLIEDIRkdv-gvPI 79  Sulfolobus solfa...
NP_394264     2 KPFVYFTLGYry--dAIAEFMRNSDg-vYAFEFGFPTSKPVYDGIRIRKTHDPELnrys-eaenSRIFKIADdi--gsKK 75  Thermoplasma aci...
NP_560026     6 GLGVYLVASWpskdtYEKAIRGLEGi-aDFFELGLPSKNPKYDGPFIRKAHREAG---------EPLWLRPQa-----PT 70  Pyrobaculum aero...
AAT42930      3 NLIPYFTLGYpdnetLKRFLMAMPInmiNYIEFGFPSNDPRYDGPTIRKTHRIGNenyd-esfyIDIFNYFNdh--niKM 79  Picrophilus torr...
YP_438000    11 LVMSHAVVGYpsleaNLPAIDALVVagvKMIELQIPFSDPVADGPTLAHACHVALkngggvkqaLALAAQVSrrhpqvSF 90  Hahella chejuens...
ZP_01076313  19 LAMTHVIYGYpsigaSLEWMQTLLEmgvETLEVQFPFSDPVADGPSIVQACHKALesepkmqqcLADLGRLGrdypnsKI 98  Marinomonas sp. ...
Feature 1           #                                                                           
1WXJ_A       95 FLMTYLNPVLawgpeRFFGLFKQagatGVILPDLPp---dEDPGLVRLAQeiGLETVFLLAPTSTDARIATVvrhatGFV 171 Thermus thermoph...
1TJP_A       98 GLLMYANLVFnngidAFYARCEQvgvdSVLVADVPv---eESAPFRQAALrhNIAPIFICPPNADDDLLRQVasygrGYT 174 Salmonella typhi...
Q9Y8T3       85 IVMAYATEQPws-fsEVLREASRkgalSVLPPDLPfelpgHVEWYVEESRrlGMEPSLFASPKFPHRWLDRYrr-ldPLL 162 Aeropyrum pernix K1
BAB60198     76 YALLYYSVFSgk--kGILDYLSSsrfdGVMVPDVGidypdRIEQVAKAIAdhGMDYVPFVTPVTPFKIMERQmk-vsGEI 152 Thermoplasma vol...
P50382       80 IALTYLEDWVdq-leNFLNMIKDvkldGILFPDLLidyidDLDKIDGIIKnkGLKNVIFTSPSVPDLLIHKVsk-isDLF 157 Sulfolobus solfa...
NP_394264    76 YALMYYEVLSan--pGILDYLNRngfaGAILPDLMidhrdAFFDAVERLRqySLDYVPFVTPITPVKVMEEQia-agGDW 152 Thermoplasma aci...
NP_560026    71 YIMTYWEEHRgn-ldGLFTLAAEirarGVLAPDLLidfpeELELYLKYAReyALAPAFFVPGKFPHWLVKRLts-aePDF 148 Pyrobaculum aero...
AAT42930     80 YSLSYYSDIKdi--eRFAAVLSNlgfsGSIIPDLLidyydEAFDVINKLNemHFEYIPFFTPSTPDNVIKKVse-ktYSW 156 Picrophilus torr...
YP_438000    91 LLMSYLNPLYrygldRLFTDAAEagvkGLIIPDLPv---eALEPHLPLLDklGLAPIMMVTPVTPPERLQRIsnaarGML 167 Hahella chejuens...
ZP_01076313  99 LLMSYLNPVYrfgitKLVKEAAEqgltGLILPDLPi---eHATEYQAACVeyNLDAIWLITPNMPKERIKQIagqatGML 175 Marinomonas sp. ...
Feature 1               #                                                                       
1WXJ_A      172 YAVSVTGVTGMRerl--peeVKDLVRRIKar-taLPVAVGFGVSGK-ATAAQAAv-ADGVVVGSALVRAlee-------- 238 Thermus thermoph...
1TJP_A      175 YLLSRSGVTGAEnrg--alpLHHLIEKLKey-haAPALQGFGISSPeQVSAAVRagAAGAISGSAIVKIieknlaspkqm 251 Salmonella typhi...
Q9Y8T3      163 IYLGLQPATGVKlp----laFLRNVKTARkivgqVYMLAGFSIKSPeDALRVLEagADAVVVGSEVARLvssgrl--gea 236 Aeropyrum pernix K1
BAB60198    153 VYQGMMPATGIQlp----ydIGTIYGHIRdftsgKRIVYGFGIRNKcTIAKIAKygGFGIAVGTAVVEMlddg------n 222 Thermoplasma vol...
P50382      158 LYYGVRPTTGVPip----vsVKQLINRVRnl-veNKLIVGFGLSSEsDLRDALSagADGIAIGTVFIEEierngv--ksa 230 Sulfolobus solfa...
NP_394264   153 IYQGMMPATGVQlp----ysIDAIYNHIRpyaggKRIVYGFGIRDAgTMKMLASyeAFGIAVGTAVVEMmenl------d 222 Thermoplasma aci...
NP_560026   149 IYLGLYAATGVElp----vyVERNVKIIRqlagdVYIVAGFAIDSPsKAARLIEagADGVVVGTAFMRRlqnsvd---sa 221 Pyrobaculum aero...
AAT42930    157 IYYGLQPSTGIDip----ydLDYTCNRIFslvksREINFGFGIKTIeDVSGLIRrgASGVAIGSYLVNMldgn------d 226 Picrophilus torr...
YP_438000   168 YVVARTGVTGSQtrw--daeFDEYIARLRgy-ttLPLAVGFGVRSAeDLRQLRGr-VEVAAVCSRYIEWqgelgg--eaa 241 Hahella chejuens...
ZP_01076313 176 YCVSRSGVTGQKsslqtefdLVAYLAEIRqh-tdVPLAVGFGIRSPeQVAELTGl-ADIAIVGSALLDTynqggi--asg 251 Marinomonas sp. ...
Feature 1                   
1WXJ_A      239 grsLAPLLQEIR 250 Thermus thermophilus HB8
1TJP_A      252 laeLRSFVSAMK 263 Salmonella typhimurium
Q9Y8T3      237 rhlACSIRAAIS 248 Aeropyrum pernix K1
BAB60198    223 vkaYRQLINDIL 234 Thermoplasma volcanium GSS1
P50382      231 inlVKKFRAILD 242 Sulfolobus solfataricus P2
NP_394264   223 tasYRRLIETIM 234 Thermoplasma acidophilum DSM 1728
NP_560026   222 lsfLKSIKEALK 233 Pyrobaculum aerophilum str. IM2
AAT42930    227 lngFLDYLKRIR 238 Picrophilus torridus DSM 9790
YP_438000   242 aerMAELCEAAG 253 Hahella chejuensis KCTC 2396
ZP_01076313 252 kalVAKLFPQLT 263 Marinomonas sp. MED121

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